Le reti di distribuzione idrica nella sicurezza antincendio - Verifiche con il codice INFOWORKS WS

Le reti di distribuzione idrica conservano un ruolo importante ed irrinunciabile nella sicurezza antincendio, ma diversi fattori sul piano normativo e strutturale limitano la loro potenzialità  nelle fasi di estinzione dell'incendio. Ma in che modo si è evoluta in Italia negli ultimi anni la lotta all'incendio? E' ormai noto che non esistono incendi standard, quelli per i quali è possibile definire procedure d'intervento e modalità  di estinzione; non è quindi banale identificare le portate antincendio necessarie (Needed Fire Flow) e il tempo per il quale esse devono essere garantite. In certi contesti è possibile ipotizzare un certo standard d'incendio ma ciò presuppone che edifici, strutture e tutto ciò che è sottoposto ad incendio, possano essere considerati fabbricati a "regola d'arte", ovvero realizzati attraverso procedure esecutive aventi standard di qualità  certificata. Ciò è stato affrontato nei criteri di realizzazione delle nuove costruzioni, ma le vecchie costruzioni, soprattutto gli edifici presenti nei centri storici, sono evidentemente più vulnerabili e sfuggono alla possibilità  di identificare affidabili valori del NFF. Il quadro che si presenta coinvolge quindi carenze normative, contesti urbani con differente vulnerabilità  e una sostanziale disomogeneità  prestazionale delle reti di distribuzione idrica presenti nel territorio nazionale, legata non solo alla disponibilità  idrica ma, anche e soprattutto, alla conformazione della rete, ai livelli di pressione ed alla specifica capacità della rete nel sostenere incrementi di flusso dovuto al prelievo dagli idranti stradali. La scarsa conoscenza di questi aspetti, piuttosto che tradursi in miglioramenti della rete idrica e della sua efficienza ai fini antincendio, ha portato nel tempo ad adottare soluzioni alternative che agiscono principalmente sulle modalità operative di utilizzo dei mezzi dei VV.F. e sul fronte dei dispositivi antincendio privati, quali una migliore protezione passiva, legata all'uso di materiali la cui risposta all'incendio fosse la minore possibile, e protezioni attive alternative, quali impianti sprinkler, di tipo aerosol o misti. Rimangono tutte le problematiche legate alla caratterizzazione nell'area urbanizzata in termini di risposta al prelievo per incendio dagli idranti pubblici sui quali la normativa vigente non impone regole circa le prestazioni e la loro dislocazione sul territorio. Questa incertezza spesso si traduce in un maggiore dispiego di mezzi rispetto all'entità dell'incendio ed ad una scarsa possibilità  di ottimizzare l'allocazione delle unità  operative dei VV.F., con un evidente incremento del rischio nel caso in cui si verifichino più eventi di incendio contemporaneamente. La simulazione numerica avanzata, su modelli opportunamente calibrati delle reti di distribuzione, può consentire una maggiore comprensione quantitativa del livello di sicurezza antincendio offerto da una rete di distribuzione idrica.

La carriera degli attori italiani di prosa dalla scena allo schermo (1909-1916)

Most actors of the Italian silent cinema in the early 1910s have a theatrical training. Some of them are already asserted or famous actors (like Cesare Dondini, Ermete Novelli, Ermete Zacconi, Giovanni Grasso) who are invited “to pose” for the cinema following their reputation, according to a strategy of an aesthetic and cultural legitimacy launched in 1909 by film d'art of the Pathé Consortium. I think it is the proverbial readiness and strength of the stage Italian actors that create a decisive contribution to the rapid development of the national cinema industry, despite its serious structural deficiencies, from the protoindustrialized phase (1909) to the golden age of divismo (starting in 1913), until the first signs of decadence (1919), and the so-called “fall” of the UCI production and distribution system. This is the main topic of the thesis: an investigation on the Italian stage actors engaged in the film industry (“from stage to screen” as the Italian title says, but in a “post-Vardac” approach) through many different sources: periodicals, memories, personal and business letters, and also contracts, found in several archive funds. A specific chapter is dedicated to the artistic career of Febo Mari (1881-1939), real name Alfredo Rodriguez, witch is a time-sample symptomatic of deep ties established between the growing film publishing and the Italian theatrical production system in the 1910s. The Mari debut in cinema and his ascent toward screen “divo” status coincides with the parable that leads from emergence to decadence of divismo in Italy.

Da alleati vittoriosi ad acerrimi rivali: i processi di ri-allineamento dopo i conflitti egemonici. Teorie a confronto e studio di casi

Why some powers manage to coordinate their security efforts while others confront each other as rivals is still one of the most relevant and debated questions in the field of IR theory. The dissertation wants to give a contribution to this important debate. In particular, the main goal of the research is to analyse the dynamics of great power interactions after the end of hegemonic conflicts, that is to understand why, following the defeat of the common enemies, some of the winning allies continue to cooperate, while others begin to engage in political and military competition. In order to understand this difference, the study compares the explanatory value of two rival theoretical perspectives: neorealism, in its main version of the balance of power framework, and a liberal approach focused on domestic politics. The thesis is divided in two sections. In the first, I do summarize the main assumptions and predictions of the theories, from which I derive two different sets of hypotheses on the evolution of post-war great power relations. In the second part, I test the hypotheses by focusing on two cases of post-war alignment dynamics: 1) the relations among Austria, Prussia, Russia, Great Britain and France after the Napoleonic wars; 2) the relations among the US, the UK, France and Italy after the end of WWI. The historical cases disconfirm the logic of the balance of power and confirm the liberal hypotheses, seeing that the results of the analysis show changes in the domestic structures of the great powers had a much larger impact on the emergence of new alliances and rivalries than did the international distribution of power. In the conclusion of the dissertation, I provide the reader with a discussion of the main theoretical implications of the empirical findings.

Strategies to identify and further characterize novel and known genes involved in regulation of skeletogenesis

372 osteochondrodysplasias and genetically determined dysostoses were reported in 2007 [Superti-Furga and Unger, 2007]. For 215 of these conditions, an association with one or more genes can be stated, while the molecular changes for the remaining syndromes remain illusive to date. Thus, the present dissertation aims at the identification of novel genes involved in processes regarding cartilage/ bone formation, growth, differentiation and homeostasis, which may serve as candidate genes for the above mentioned conditions. Two different approaches were undertaken. Firstly, a high throughput EST sequencing project from a human fetal cartilage library was performed to identify novel genes in early skeletal development (20th week of gestation until 2nd year of life) that could be investigated as potential candidate genes. 5000 EST sequences were generated and analyzed representing 1573 individual transcripts, corresponding to known (1400) and to novel, yet uncharacterized genes (173). About 7% of the proteins were already described in cartilage/ bone development or homeostasis, showing that the generated library is tissue specific. The remaining profile of this library was compared to previously published libraries from different time points (8th–12th, 18th–20th week and adult human cartilage) that also showed a similar distribution, reflecting the quality of the presented library analyzed. Furthermore, three potential candidate genes (LRRC59, CRELD2, ZNF577) were further investigated and their potential involvement in skeletogenesis was discussed. Secondly, a disease-orientated approach was undertaken to identify downstream targets of LMX1B, the gene causing Nail-Patella syndrome (NPS), and to investigate similar conditions. Like NPS, Genitopatellar syndrome (GPS) is characterized by aplasia or hypoplasia of the patella and renal anomalies. Therefore, six GPS patients were enrolled in a study to investigate the molecular changes responsible for this relatively rare disease. A 3.07 Mb deletion including LMX1B and NR5A1 (SF1) was found in one female patient that showed features of both NPS and GPS and investigations revealed a 46,XY karyotype and ovotestes indicating true hermaphroditism. The microdeletion was not seen in any of the five other patients with GPS features only, but a potential regulatory element between the two genes cannot be ruled out yet. Since Lmx1b is expressed in the dorsal limb bud and in podocytes, proteomic approaches and expression profiling were performed with murine material of the limbs and the kidneys to identify its downstream targets. After 2D-gel electrophoresis with protein extracts from E13.5 fore limb buds and newborn kidneys of Lmx1b wild type and knock-out mice and mass spectrometry analysis, only two proteins, agrin and carbonic anhydrase 2, remained of interest, but further analysis of the two genes did not show a transcriptional down regulation by Lmx1b. The focus was switched to expression profiles and RNA from newborn Lmx1b wild type and knock-out kidneys was compared by microarray analysis. Potential Lmx1b targets were almost impossible to study, because of the early death of Lmx1b deficient mice, when the glomeruli, containing podocytes, are still immature. Because Lmx1b is also expressed during limb development, RNA from wild type and knock-out Lmx1b E11.5 fore limb buds was investigated by microarray, revealing four potential Lmx1b downstream targets: neuropilin 2, single-stranded DNA binding protein 2, peroxisome proliferative activated receptor, gamma, co-activator 1 alpha, and short stature homeobox 2. Whole mount in situ hybridization strengthened a potential down regulation of neuropilin 2 by Lmx1b, but further investigations including in situ hybridization and protein-protein interaction studies will be needed.

La distribuzione del potere tra le Istituzioni Europee e la procedura di co-decisione. Il caso della riforma della Politica Agricola Comune

Questa ricerca analizza le implicazioni derivanti dall’introduzione della procedura di co-decisione come procedura legislativa ordinaria nel processo di riforma della politica agricola comune. La diversa distribuzione dei poteri tra le istituzioni europee modifica gli assetti istituzionali e fornisce al Parlamento il ruolo di colegislatore in materia agricola. La forma assunta dalla nuova politica agricola europea scaturisce dalla configurazione dei poteri di contrattazione che ciascun attore ha mostrato nella sede dei triloghi negoziali. La ricerca tenta di verificare la accuratezza predittiva di diversi modelli di contrattazione legislativa attraverso il confronto e la verifica degli errori di predizione sui risultati finali di alcune questioni salienti della riforma della Politica Agricola Comune e allo stesso tempo, cerca di identificare il peso del potere del Parlamento europeo in veste di co-legislatore nel processo di riforma della PAC post-2013.

The role of indigenous people in national development processes: Participation and marginalisation of indigenous Bedouin in South Sinai tourism development

The Bedouin of South Sinai have been significantly affected by the politics of external powers for a long time. However, never had the interest of external powers in Sinai been so strong as since the Israeli-Egyptian wars in the second half of the 20th century when Bedouin interests started to collide with Egypt’s plans for a development of luxury tourism in South Sinai. rnrnThe tourism boom that has started in the 1980s has brought economic and infrastructure development to the Bedouin and tourism has become the most important source of income for the Bedouin. However, while the absolute increase of tourists to Sinai has trickled down to the Bedouin to some extent, the participation of Bedouin in the overall tourism development is under-proportionate. Moreover, the Bedouin have become increasingly dependent on monetary income and consequently from tourism as the only significant source of income while at the same time they have lost much of their land as well as their self-determination.rnrnIn this context, the Bedouin livelihoods have become very vulnerable due to repeated depressions in the tourism industry as well as marginalization. Major marginalization processes the Bedouin are facing are the loss of land, barriers to market entry, especially increasingly strict rules and regulations in the tourism industry, as well as discrimination by the authorities. Social differentiation and Bedouin preferences are identified as further factors in Bedouin marginalization.rnrnThe strategies Bedouin have developed in response to all these problems are coping strategies, which try to deal with the present problem at the individual level. Basically no strategies have been developed at the collective level that would aim to actively shape the Bedouin’s present and future. Collective action has been hampered by a variety of factors, such as the speed of the developments, the distribution of power or the decay of tribal structures.rnWhile some Bedouin might be able to continue their tourism activities, a large number of informal jobs will not be feasible anymore. The majority of the previously mostly self-employed Bedouin will probably be forced to work as day-laborers who will have lost much of their pride, dignity, sovereignty and freedom. Moreover, with a return to subsistence being impossible for the majority of the Bedouin, it is likely that an increasing number of marginalized Bedouin will turn to illegal income generating activities such as smuggling or drug cultivation. This in turn will lead to further repression and discrimination and could escalate in a serious violent conflict between the Bedouin and the government.rnrnDevelopment plans and projects should address the general lack of civil rights, local participation and protection of minorities in Egypt and promote Bedouin community development and the consideration of Bedouin interests in tourism development.rnrnWether the political upheavals and the resignation of president Mubarak at the beginning of 2011 will have a positive effect on the situation of the Bedouin remains to be seen.rn

Contemporary Hollywood And The Attention Economy

This thesis had two goals: to explore the transformation of Hollywood from the 1930s to present, and to investigate how Contemporary Hollywood functions in a growing attention economy. Evident in the types of films that it produces as well as its evolving industrial structure, Contemporary Hollywood significantly differs from the Classical Hollywood of the 1930s. New digital technologies like surround sound and computer-generated imagery (CGI) have allowed studios to create a different type of film like the blockbuster and to have more extensive control over their films. Additionally, growing exhibition and distribution platforms have also fundamentally altered the industrial landscape of Hollywood. In order to combat this more egalitarian distribution system, Contemporary Hollywood has turned to conglomeratization. But, what has caused such a radical shift in the form and function of Contemporary Hollywood and its films? This thesis argues that Hollywood is failing to thrive in this new media landscape¿not because of changing technologies¿but because of a changing consumer. Richard Lanham theorizes that we are living in a growing attention economy, where human attention is the most valuable commodity in such an information-saturated society. For the current consumer, there is near-constant media over-stimulation: he or she is exposed to any number of screens (mobile phones, laptops, tablets, televisions, etc.) at any given time. Because we can access anything from anywhere at anytime, we¿ve become somewhat schizophrenic and impatient in terms of the media that we consume in our lives.

Economic and Social Changes in Czech Society after 1989: an Alternative View

The group presents an analysis of the development of the Czech society and economy during the 1990s. They believe that the Czech neo-liberal strategy of transformation led to a partial and uneven modernisation and that this strategy is unable to provide a firm basis for a complex process of modernisation. The increasing developmental problems encountered during 1996-1999 can be seen as empirical evidence of the inadequacy of the neo-liberal transformation strategy. These problems are connected to institutional shortcomings due to the excessive speed of privatisation, its form with certain important Czech innovations (particularly the voucher method and an attempt to resuscitate the Czech national capital) and with the overlooking of the importance of the legal framework and its enforcement. The overly hasty privatisation has created a type of 'recombinant property' which lacks the economic order necessary to stimulate efficiency in an atmosphere of prevailing social justice. A second reason for the present difficulties is the long-term lag behind the civilisation and cultural standards typical of the advanced European countries. The first steps of the Czech transformation concentrated mainly on changes in the institutions important for the distribution of power and wealth and largely neglected the necessity of deep-reaching modernisation of Czech society and the economy. The neo-liberal strategy created conditions conducive to predatory and speculative behaviour at the expense of creative behaviour. Inherited principles of egalitarianism combined with undeserved economic privileges survived and were reinforced by important new developments in the same direction. This situation hinders the assertion of meritocratic motivations. The group advocates the development and implementation of a complex strategy of modernisation based on deliberate reforms, institutional changes and restructuring on the basis of strategic planning, and structural and regional policies which stress the role of cultivation of the institutional order and of the most important factors of economic growth and development.

A pharmaco-EEG study on antipsychotic drugs in healthy volunteers

RATIONALE: Both psychotropic drugs and mental disorders have typical signatures in quantitative electroencephalography (EEG). Previous studies found that some psychotropic drugs had EEG effects opposite to the EEG effects of the mental disorders treated with these drugs (key-lock principle). OBJECTIVES: We performed a placebo-controlled pharmaco-EEG study on two conventional antipsychotics (chlorpromazine and haloperidol) and four atypical antipsychotics (olanzapine, perospirone, quetiapine, and risperidone) in healthy volunteers. We investigated differences between conventional and atypical drug effects and whether the drug effects were compatible with the key-lock principle. METHODS: Fourteen subjects underwent seven EEG recording sessions, one for each drug (dosage equivalent of 1 mg haloperidol). In a time-domain analysis, we quantified the EEG by identifying clusters of transiently stable EEG topographies (microstates). Frequency-domain analysis used absolute power across electrodes and the location of the center of gravity (centroid) of the spatial distribution of power in different frequency bands. RESULTS: Perospirone increased duration of a microstate class typically shortened in schizophrenics. Haloperidol increased mean microstate duration of all classes, increased alpha 1 and beta 1 power, and tended to shift the beta 1 centroid posterior. Quetiapine decreased alpha 1 power and shifted the centroid anterior in both alpha bands. Olanzapine shifted the centroid anterior in alpha 2 and beta 1. CONCLUSIONS: The increased microstate duration under perospirone and haloperidol was opposite to effects previously reported in schizophrenic patients, suggesting a key-lock mechanism. The opposite centroid changes induced by olanzapine and quetiapine compared to haloperidol might characterize the difference between conventional and atypical antipsychotics.

Post-project assessment and follow-up support for community managed rural water systems in Panama

The Environmental Health (EH) program of Peace Corps (PC) Panama and a non-governmental organization (NGO) Waterlines have been assisting rural communities in Panama gain access to improved water sources through the practice of community management (CM) model and participatory development. Unfortunately, there is little information available on how a water system is functioning once the construction is complete and the volunteer leaves the community. This is a concern when the recent literature suggests that most communities are not able to indefinitely maintain a rural water system (RWS) without some form of external assistance (Sara and Katz, 1997; Newman et al, 2002; Lockwood, 2002, 2003, 2004; IRC, 2003; Schweitzer, 2009). Recognizing this concern, the EH program director encouraged the author to complete a postproject assessment of the past EH water projects. In order to carry out the investigation, an easy to use monitoring and evaluation tool was developed based on literature review and the author’s three years of field experience in rural Panama. The study methodology consists of benchmark scoring systems to rate the following ten indicators: watershed, source capture, transmission line, storage tank, distribution system, system reliability, willingness to pay, accounting/transparency, maintenance, and active water committee members. The assessment of 28 communities across the country revealed that the current state of physical infrastructure, as well as the financial, managerial and technical capabilities of water committees varied significantly depending on the community. While some communities are enjoying continued service and their water committee completing all of its responsibilities, others have seen their water systems fall apart and be abandoned. Overall, the higher score were more prevalent for all ten indicators. However, even the communities with the highest scores requested some form of additional assistance. The conclusion from the assessment suggests that the EH program should incorporate an institutional support mechanism (ISM) to its sector policy in order to systematically provide follow-up support to rural communities in Panama. A full-time circuit rider with flexible funding would be able to provide additional technical support, training and encouragement to those communities in need.

Elaboración de vinos : defectos en el proceso que originan costos de no calidad

Los costos de calidad se asocian a su planificación, control, evaluación de la conformidad y a los costos ocasionados por no cumplir con los requisitos de satisfacción de la fábrica o del cliente (productos o servicios con defectos). Los objetivos del trabajo son identificar las causas que provocan la ausencia o pérdida de calidad (no calidad), proponer acciones correctivas en el proceso de elaboración de vinos, midiendo la frecuencia de aparición y clasificando los costos de no calidad. Conocer la frecuencia de aparición de las causas de no calidad en las etapas del proceso de elaboración de vinos permitirá optimizar la gestión y reducir los costos al disminuir sus correcciones. El estudio identifica los factores que alteran la calidad de los vinos. La mayor frecuencia de defectos es de origen prefermentativo, que junto con los de crianza, conservación y originados en el viñedo explican el 79% de los mismos. Los defectos encontrados constituyen costos de prevención y evaluación pero serán falla interna si la bodega está integrada y se atribuirán a falla externa en el caso de productor no integrado. Los establecimientos en los que se pudo identificar y establecer frecuencia de aparición de los defectos que influyen en la calidad del vino son aquellos que tienen algún sistema de gestión de la calidad, ya que han normalizado los registros que actuarán como herramienta de gestión. Los encargados de gerenciar las bodegas deberían conocer los puntos críticos del proceso para realizar la gestión preventiva de los posibles defectos. Los costos que inciden en la calidad del producto a comercializar se deben registrar y controlar, y trazarlos hacia adelante para conocer la incidencia de los mismos en los precios finales, y hacia atrás para que en la planificación de la próxima elaboración se contemple la prevención correspondiente.