Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study.

Background.  The impact of human genetic background on low-trauma fracture (LTF) risk has not been evaluated in the context of human immunodeficiency virus (HIV) and clinical LTF risk factors. Methods.  In the general population, 6 common single-nucleotide polymorphisms (SNPs) associate with LTF through genome-wide association study. Using genome-wide SNP arrays and imputation, we genotyped these SNPs in HIV-positive, white Swiss HIV Cohort Study participants. We included 103 individuals with a first, physician-validated LTF and 206 controls matched on gender, whose duration of observation and whose antiretroviral therapy start dates were similar using incidence density sampling. Analyses of nongenetic LTF risk factors were based on 158 cases and 788 controls. Results.  A genetic risk score built from the 6 LTF-associated SNPs did not associate with LTF risk, in both models including and not including parental hip fracture history. The contribution of clinical LTF risk factors was limited in our dataset. Conclusions.  Genetic LTF markers with a modest effect size in the general population do not improve fracture prediction in persons with HIV, in whom clinical LTF risk factors are prevalent in both cases and controls.

Central America : conditions of refugees and displaced persons : report to congressional requesters /

"B-233434"--p.[1]

Central America : conditions of Guatemalan refugees and displaced persons : report to congressional requesters /

Cover title.

[Persons of Hispanic origin in the United States, 1990 /

"These tables present 1990 census estimates of 28 Hispanic origin groups, based on sample tabulations, for the United States and each state"--Letter of transmittal.

Characteristics of households and persons receiving noncash benefits, 1979 : preliminary data from the March 1980 Current Population Survey.

Mode of access: Internet.

Industrial characteristics of persons reporting morbidity during the health interview surveys conducted in 1969-1974 : an exploratory review /

Mode of access: Internet.

Assigned occupations of persons employed on WPA projects, November 1937.

"Prepared ... by Glen S. Taylor and Donald R. Gillies ..."--p. [ii]

An age dependent, absorbing, semi-Markov model of post-entitlement work histories of the disabled beneficiaries /

"June 1980."

Official register of the United States : persons in the civil, military, and naval service, exclusive of the Postal Service /

Subtitle varies.

Health care services for persons with human immunodeficiency virus (HIV) infection.

"September 1993."

The Competing demands of employment and informal caregiving to disabled elders.

Mode of access: Internet.

Convention relating to the status of stateless persons:

Mode of access: Internet.

Evaluation support for innovative alcohol projects: evaluation support for assessing the effectiveness of videotaping persons arrested for DWI. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Electrical engineering : an elementary textbook suitable for persons employed in the mechanical and electrical engineering trades /

Mode of access: Internet.

Plain catechetical instruction for young communicants, designed to assist them in forming Scriptural views of the Lord's Supper. With an address to young persons not yet communicants, and a few meditations and helps for self-examination.

Mode of access: Internet.