On the distribution of income and worker assignment under intra-firm spillovers, with an application to ideas and networks

We study the earnings structure and the equilibrium assignment of workers when workers exert intra-firm spillovers on each other.We allow for arbitrary spillovers provided output depends on some aggregate index of workers' skill. Despite the possibility of increasing returns to skills, equilibrium typically exists. We show that equilibrium will typically be segregated; that the skill space can be partitioned into a set of segments and any firm hires from only one segment. Next, we apply the model to analyze the effect of information technology on segmentation and the distribution of income. There are two types of human capital, productivity and creativity, i.e. the ability to produce ideas that may be duplicated over a network. Under plausible assumptions, inequality rises and then falls when network size increases, and the poorest workers cannot lose. We also analyze the impact of an improvement in worker quality and of an increased international mobility of ideas.

Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients.

OBJECTIVE: To evaluate the efficacy and safety of intravenous fluconazole for the prevention of intra-abdominal Candida infections in high-risk surgical patients. DESIGN: Randomized, prospective, double-blind, placebo-controlled study. SETTING: Two university-affiliated hospitals in Switzerland. PATIENTS: Forty-nine surgical patients with recurrent gastrointestinal perforations or anastomotic leakages. INTERVENTIONS: Prophylaxis with intravenous fluconazole (400 mg per day) or placebo continued until resolution of the underlying surgical condition. MEASUREMENTS AND MAIN RESULTS: Patients were evaluated daily, and specimens for culture were obtained three times per week during prophylaxis. The primary study end points were the frequency of and the time to intra-abdominal Candida infections. Secondary end points were the frequency of candidiasis (intra-abdominal and extra-abdominal) and the emergence or persistence of Candida colonization. Among patients who were not colonized at study entry, Candida was isolated from surveillance cultures during prophylaxis in 15% of the patients in the fluconazole group and in 62% of the patients in the placebo group (relative risk, 0.25; 95% confidence interval, 0.07 to 0.96; p = .04). Candida peritonitis occurred in one of 23 patients (4%) who received fluconazole and in seven of 20 patients (35%) who received placebo (relative risk, 0.12; 95% confidence interval, 0.02 to 0.93; p = .02). In addition, one catheter-related Candida albicans sepsis occurred in a fluconazole-treated patient. Thus, overall, candidiasis developed in two fluconazole patients and seven placebo patients (relative risk, 0.25; 95% confidence interval, 0.06 to 1.06; p = .06). C. albicans accounted for 87% of the Candida species isolated before or during prophylaxis, and all C. albicans strains were susceptible to fluconazole. Fluconazole was well tolerated, and adverse events occurred at similar frequencies in both treatment groups. CONCLUSIONS: Fluconazole prophylaxis prevents colonization and invasive intra-abdominal Candida infections in high-risk surgical patients.

Growth arrest-specific gene 6 » (Gas6) as an intra-hospital mortality predictor for patients in septic shock

Aim: Gas6 is known to be elevated in sepsis, correlating with the severity of infection and¦organ failure. We aimed to investigate the performance of Gas6 plasma levels at¦admission to predict the risk of mortality in a cohort of septic patients.¦Methods: We used prospectively collected data and plasma samples from the "Sepsis¦Cohorte Romande". Gas6 level was measured by ELISA at admission and expressed in¦percentage relative to its level in a pool of normal plasma.¦Results: Non-survivors (n=21) presented higher Gas6 levels than survivors (n=73) (median¦258% vs 164%, IQR 194 and 117 respectively) (p=0.0027). Gas6 correlated positively with¦different cytokines and was the best mortality predictor, as shown by the ROC curves area.¦In patients with septic shock (n=66), using 249% as a cut-off value, Gas6 measurement¦had a specificity of 67% and a sensitivity of 81% for predicting mortality. ROC curve area¦was 0.75. Positive and negative predictive values were 57% and 87%, respectively.¦Conclusion: Thus, Gas6 plasma level at admission might be a useful tool to predict¦mortality in patients with septic shock. Although Gas6 hold promise as an early sepsis¦marker, its precise implication in sepsis remains to be elucidated. Our observation should¦be further investigated in larger prospective clinical trials.

Lésions endothéliales des ballons de contre-pulsion intra-aortique [Endothelial lesions caused by intra-aortic counterpulsation balloons]

Intra-aortic balloon pump (IABP) is the most frequently used mechanical circulatory support. Repeated trauma on the aortic wall has been reported as a cause of balloon perforation by endothelial denudation of atheromatous plaque. This study analyses the effect of IABP on the endothelium of the calf aorta. In 12 calves (mean weight: 72 +/- 6 kg) an IABP was inserted by femoral route and left during 6 hours on internal mode with a frequency of 80 cycles/min. The animals were sacrificed after the procedure (n = 4), at postoperative day (POD) 7 (n = 4), and at POD 14 (n = 4). In the aorta facing the balloon, nine transmural samples were taken proximally (n = 3), at mid height (n = 3) and distally (n = 3), for histological analysis of the percentage of aortic surface covered with endothelium. The percentage of aortic surface covered with endothelium at POD 0, 7 and 14 was proximally: 72.5 +/- 27.5%, 83.7 +/- 16.9% and 93.3 +/- 8.9% respectively; at mid-height: 50.8 +/- 30.7%, 65 +/- 25% and 95 +/- 5%; and distally: 31.4 +/- 20.1%, 48.3 +/- 34.4% and 85 +/- 10%. A large portion of the aortic endothelium is abraded after 6 hours of IAB pumping. This effect is more important at the distal level of the aorta. After two weeks, most of the endothelium has regenerated.

O Comércio Intra-sectorial entre Portugal e os Países da União Europeia

A presente investigação tem como objectivo analisar a evolução do comércio intra-sectorial nas relações bilaterais entre Portugal e os países da União Europeia durante o período de 1995-2008 para os sectores: 31 e 34 e o impacto sobre das principais variáveis explicativas: diferença do rendimento per capita, diferença das dotações relativas, valor mínimo do rendimento per capita, valor máximo do rendimento per capita, BORDER (adjacência/fronteira), distância geográfica e dimensão do mercado (das economias) sobre o comércio intra-sectorial. A intensidade e a contribuição do comércio intra-sectorial é medida em termos absolutos e relativos através do índice proposto por Grubel e Lloyd (1975); a desagregação do comércio intra-sectorial horizontal e vertical é efectuada utilizando o critério de Abd-EL-Rahman (1991) e Grenaway et al. (1994) aplicado ao índice de Grubel e Lloyd. Os resultados obtidos mostraram que o comércio intra-sectorial vertical representa maior peso no total do comércio intra-sectorial nas relações bilaterais entre Portugal e a União Europeia, para ambos os sectores tanto em termos absolutos como em termos relativos. Em termos dos resultados econométricos verificou-se que a variável, proxy diferença do consumo eléctrico per capita utilizada para medir as dotações relativas possui um efeito negativo sobre o comércio intra-sectorial. As variáveis dimensão do mercado e valor mínimo do rendimento per capita apresentam um impacto positivo sobre o comércio intra-sectorial.

Intravitreal ranibizumab for age-related macular degeneration : optical coherence tomography guided retreatment intervals and their intra- and inter-individual variability

Purpose: To determine whether the need for retreatment after an initial phase of 3 monthly intravitreal injections of ranibizumab shows an intra-individual regular rhythm and to what degree it varies between different patients. Methods: Prospective study with 42 patients with exudative AMD, treatment naïve. Loading dose of 3 monthly doses of ranibizumab (0,5 mg), followed by a 12 months pro re nata (PRN) regimen according to early exudative signs on HD-OCT Cirrus, Zeiss. The follow-up visits were intensified (week 4, 5, 6, 7, 8, 10, 12, 14, 16, 20, etc after each injection) in order to detect recurrences early, and injection followed within 3 days in cases of subretinal fluid, cysts, or central thickness increase of>50microns. Intervals were calculated between injections for the 12 month follow-up with PRN treatment. Variability was expressed as standard deviation (SD). Results: Visual acuity (VA) improved from a mean ETDRS score of 61.6 (SD 10.8) at baseline to 68.0 (SD 10.2) at month 3 and to 74.7(SD 9.0) at month 12. The 15 patients who have already completed the study showed maintenance of the VA improvement. Central foveal thickness improved from a mean value of 366 microns (baseline) to 253 microns (month 3), well maintained thereafter. Mean number of injections was 8.8 (SD 3.5,range 0-12) per 12 months of follow-up (after 3 doses), with mean individual treatment-recurrence (TR) intervals ranging from 28->365 days (mean 58). Intraindividual variability of TR intervals (SD) was 7.1 days as a mean value (range 1.7¡V22.6). It ranged within 20% of the mean intra-individual interval for 30 (91%) and within 15% for 21 patients (64%). The first interval was within 1 week of the mean intra-individual interval in 64% and within 2 weeks in 89% of patients. Conclusions: The majority of AMD patients showed a relatively stable rhythm for PRN injections of ranibizumab after initial loading phase, associated with excellent functional/anatomical results. The initial interval last loading dose-first recurrence may have a predictive value for further need of treatment, potentially facilitating follow-up and patient care.

Dívida Pública e Crescimento Económico: os casos de Portugal, Grécia, Itália e Espanha

Portugal, Grécia, Espanha e Itália tem vindo a apresentar um histórico de dívidas elevadas ao ponto de violarem uma das metas estabelecidas no Pacto de Estabilidade e Crescimento (PEC): rácio da dívida pública em percentagem do PIB inferior a 60%. O contínuo incumprimento reduz a margem desses países fazerem face à uma situação de contracção da actividade económica, ampliando deste modo os efeitos daí decorrentes. O objetivo principal deste trabalho prende-se com a análise da relação entre a dívida pública e o crescimento económico nos quatro países, no sentido de se aferir o grau de interdependência entre as duas variáveis. Também iremos analisar o comportamento das variáveis antes e depois do PEC, de modo a perceber se os objetivos impostos tiveram impacto nas contas públicas dos países. Para dar resposta aos objetivos propostos iremos recorrer ao modelo de cointegração de Johansen.

Influência da competição intra-específica entre fêmeas e da ausência de hospedeiro no parasitismo de Telenomus remus Nixon (Hymenoptera, Scelionidae) sobre ovos de Spodoptera frugiperda (J. E. Smith) (Lepidoptera, Noctuidae)

A competição intraespecífica e a ausência de hospedeiros podem comprometer o sucesso de programas de controle biológico. Assim, este trabalho objetivou avaliar o efeito de diferentes densidades de fêmeas (1, 3, 6 e 9 fêmeas/ 100 ovos) e da ausência de hospedeiro no parasitismo de Telenomus remus Nixon (Hymenoptera, Scelionidae) em ovos de Spodoptera frugiperda (J. E. Smith) (Lepidoptera, Noctuidae). Observou-se aumento no parasitismo de ovos de S. frugiperda por T. remus a partir da densidade 3 fêmeas/ 100 ovos tanto em condições de laboratório (18%) quanto em campo (32%), embora o parasitismo causado por densidades maiores que 1 fêmea/100 ovos não foi significativamente diferente. Todavia, isso não causou superparasitismo. Por outro lado, o número de fêmeas produzidas na progênie diminuiu (39%) com a maior densidade de fêmeas sob condições de laboratório. Contudo, não verificou-se diferença significativa sob condições de campo. Mesmo após 9 dias de ausência de hospedeiro não houve redução nos índices de parasitismo, permanecendo em torno de 95 ovos parasitados/fêmea/dia. Todavia, no décimo dia pode-se observar redução (40%) no número médio de ovos parasitados. Desse modo, a liberação de três fêmeas por 100 ovos é adequada para se obter elevados níveis de parasitismo.

The intra-generational redistributive effects of social security

This paper provides a quantitative evaluation of the intra--cohortredistributive elements of the United States social security system in thecontext of a computable general equilibrium model. I determine how thewell--being of individuals that differ across {\sl gender, race} and {\sl education}is affected by government social security policy. I find that females, whitesand non--college graduates stand less to gain (lose) from reductions(increases) in the size of social security than males, non--whites andcollege graduates, respectively. Differences in mortality risk and laborproductivity translate into differences in the magnitudes of capitalaccumulation and labor supply distortions, that are responsible for theobserved welfare difference between types. Results imply that the currentprogram is lifetime progressive across gender and education, yet lifetimeregressive across race.

Crescimento Económico em Cabo Verde e seu Impacto na Sustentabilidade Ambiental

Para que o crescimento económico seja efetivo, importa registar de igual modo o crescimento real nas outras vertentes que sustentam o próprio crescimento, assim é cada vez mais importante introduzir variáveis ambientais e sociais quando se procede à análise efetiva do crescimento económico. O “crescimento económico é um indicador que revela o bem-estar económico de um país”, (Bürgenmeier, 2005, p.16-17). Só se pode falar da sustentabilidade ao nível do crescimento económico, se efetivamente os recursos forem devidamente racionalizados, mas é igualmente muito importante ter em conta a reutilização de recursos, sobretudo quando são escassos ou quando representam riscos sérios para o ambiente como também para a economia, entre outros. O protocolo do Quioto, a Convenção Quadro sobre as Mudanças Climáticas e os Objetivos Do Milénio (ODM), são apenas alguns exemplos de programas cujos objetivos visam essencialmente disciplinar a emissão de dióxido de carbono (CO2). Um dos objetivos é o de tentar “educar” o mundo global para os problemas que decorrem do uso abusivo e descontrolado de recursos, principalmente aqueles que podem pôr em causa a sustentabilidade do planeta terra. Cabo Verde (CV) é um dos poucos países ao nível do continente africano, e único na sua sub-região, que tem cumprido com os objetivos dos projetos acima listados. Essas conquistas têm permitido que este país conduza as suas políticas de desenvolvimento, balizadas em contextos das melhores práticas mundialmente aceites. Têm sido canalizados investimentos em infraestruturas de elevado valor acrescentado para a captação e exploração de energias verdes. A presente dissertação tem como objetivos: identificar os eventuais impactos ambientais em Cabo Verde que poderão decorrer do crescimento e desenvolvimento económico; sugerir melhorias ao nível da sustentabilidade. Conclui-se, por meio de inquéritos conduzidos por nós, que os Cabo-verdianos se mostram dispostos a colaborar financeiramente para a proteção ambiental em Cabo Verde.

Intra-individual stability of neuromotor tasks from 6 to 18 years: a longitudinal study.

This study investigates the intra-individual stability of the speed of several motor tasks and the intensity of associated movements in 256 children (131 girls, 125 boys) from the Zurich generational study using the Zurich neuromotor assessment battery (ZNA) over a 12-year period from the age of 6 to 18 years. The stability was assessed by correlograms of standard deviation scores calculated from age- and gender-adjusted normative values and compared with standing height and full scale intelligence quotient (IQ). While motor tasks of hand, finger and foot (HFT) and contralateral associated movements (CAM) exhibited a moderate stability (summary measure as correlation coefficients between two measurements made 4 years apart: .61 and .60), other tasks (dynamic balance, static balance and pegboard) were only weakly stable (.46, .47 and .49). IQ and height were more stable than neuromotor components (.72 and .86). We conclude that the moderately stable HFT and CAM may reflect "motor traits", while the stability of the pegboard and balance tasks is weaker because these skills are more experience related and state-dependent.