866 resultados para Conference title: Risk-informed Disaster Management : Planning for Response, Recovery
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Dissertation submitted to Faculdade de Cincias e Tecnologia of Universidade Nova de Lisboa for the achievement of Integrated Masters degree in Industrial Management Engineering
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Dissertao de Mestrado apresentado ao Instituto de Contabilidade e Administrao do Porto para a obteno do grau de Mestre em Auditoria, sob orientao do Mestre Fernando Teixeira Pinto
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Dissertao apresentada na Faculdade de Cincias e Tecnologia da Universidade Nova de Lisboa para obteno do grau de Mestre em Engenharia Electrotcnica e de Computadores
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RESUMO: Os biomarcadores tumorais permitem identificar os doentes com maior risco de recorrncia da doena, predizer a resposta tumoral teraputica e, finalmente, definir candidatos a novos alvos teraputicos. Novos biomarcadores so especialmente necessrios na abordagem clnica dos linfomas. Actualmente, esses tumores so diagnosticados atravs de uma combinao de caractersticas morfolgicas, fenotpicas e moleculares, mas o prognstico e o planeamento teraputico esto quase exclusivamente dependentes de caractersticas clnicas. Estes factores clnicos so, na maioria dos linfomas, insuficientes numa proporo significativa dos doentes, em particular, aqueles com pior prognstico. O linfoma folicular (LF) , globalmente, o segundo subtipo mais comum de linfoma. tipicamente uma doena indolente com uma sobrevida mdia entre os 8 e 12 anos, mas geralmente fatal quando se transforma num linfoma agressivo de alto grau, habitualmente o linfoma difuso de grandes clulas B (LDGCB). Morfologicamente e funcionalmente, as clulas do LF recapitulam as clulas normais do centro germinativo na sua dependncia de sobrevivncia do microambiente no-tumoral, especialmente das clulas do sistema imunolgico. Biomarcadores preditivos de transformao no existem pelo que um melhor conhecimento da biologia intrnseca de progresso do LF poder revelar novos candidatos. Nesta tese descrevo duas abordagens distintas para a descoberta de novos biomarcadores. A primeira, o estudo da expresso global de genes ('genomics') obtidos por tcnicas de alto rendimento que analisam todo o genoma humano sequenciado, permitindo identificar novas anomalias genticas que possam representar mecanismos biolgicos importantes de transformao. So descritos novos genes e alteraes genmicas associados transformao do LF, sendo especialmente relevantes as relacionadas com os eventos iniciais de transformao em LDGCB. A segunda, baseou-se em vrias hipteses centradas no microambiente do LF, rico em vrios tipos de clulas nomalignas. Os estudos imunoarquitectural de macrfagos, clulas T regulatrias e densidade de microvasos efectuado em biopsias de diagnstico de doentes com LF tratados uniformemente correlacionaram-se significativamente, e independentemente dos critrios clnicos, com a evoluo clnica e, mais importante, com o risco de transformao em LDGCB. Nesta tese, foram preferencialmente utilizadas (e optimizadas) tcnicas que permitam o uso de amostras fixadas em parafina e formalina (FFPET). Estas so facilmente acessveis a partir das biopsias de diagnstico de rotina presentes nos arquivos de todos os departamentos de patologia, facilitando uma transio rpida dos novos marcadores para a prtica clnica. Embora o FL fosse o tema principal da tese, os novos achados permitiram estender facilmente hipteses semelhantes a outros subtipos de linfoma. Assim, so propostos e validados vrios biomarcadores promissores e relacionados com o microambiente no tumoral, sobretudo dependentes das clulas do sistema imunolgico, como contribuintes importantes para a biologia dos linfomas. Estes sugerem novas opes para a abordagem clnica destas doenas e, eventualmente, novos alvos teraputicos.------------- ABSTRACT: Cancer biomarkers provide an opportunity to identify those patients most at risk for disease recurrence, predict which tumours will respond to different therapeutic approaches and ultimately define candidate biomarkers that may serve as targets for personalized therapy. New biomarkers are especially needed in the management of lymphoid cancers. At present, these tumours are diagnosed using a combination of morphologic, phenotypic and molecular features but prognosis and overall survival are mostly dependent on clinical characteristics. In most lymphoma types, these imprecisely assess a significant proportion of patients, in particular, those with very poor outcomes. Follicular lymphoma (FL) is the second most common lymphoma subtype worldwide. It is typically an indolent disease with current median survivals in the range of 8-12 years, but is usually fatal when it transforms into an aggressive high-grade lymphoma, characteristically Diffuse Large B Cell Lymphoma (DLBCL). Morphologically and functionally it recapitulates the normal cells of the germinal center with its survival dependency on non-malignant immune and immunerelated cells. Informative markers of transformation related to the intrinsic biology of FL progression are needed. Within this thesis two separate approaches to biomarker discovery were employed. The first was to study the global expression of genes (genomics) obtained using high-throughput, wholegenome-wide approaches that offered the possibility for discovery of new genetic abnormalities that might represent the important biological mechanisms of transformation. Gene signatures associated with early events of transformation were found. Another approach relied on hypothesis-driven concepts focusing upon the microenvironment, rich in several non-malignant cell types. The immunoarchitectural studies of macrophages, regulatory T cells and microvessel density on diagnostic biopsies of uniformly treated FL patients significantly predicted clinical outcome and, importantly, also informed on the risk of transformation. Techniques that enabled the use of routine formalin fixed paraffin embedded diagnostic specimens from the pathology department archives were preferentially used in this thesis with the goal of fulfilling a rapid bench-to-beside translation for these new findings. Although FL was the main subject of the thesis the new findings and hypotheses allowed easy transition into other lymphoma types. Several promising biomarkers were proposed and validated including the implication of several non-neoplastic immune cells as important contributors to lymphoma biology, opening new options for better treatment planning and eventually new therapeutic targets and candidate therapeutics.
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Dissertao para obteno do Grau de Doutor em Engenharia Electrotcnica e de Computadores
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Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.
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The quality of care can be improved by the development and implementation of evidence-based treatment guidelines. Different national guidelines for chronic obstructive pulmonary disease (COPD) exist in Europe and relevant differences may exist among them.This was an evaluation of COPD treatment guidelines published in Europe and Russia in the past 7years. Each guideline was reviewed in detail and information about the most important aspects of patient diagnosis, risk stratification and pharmacotherapy was extracted following a standardised process. Guidelines were available from the Czech Republic, England and Wales, Finland, France, Germany, Italy, Poland, Portugal, Russia, Spain and Sweden. The treatment goals, criteria for COPD diagnosis, consideration of comorbidities in treatment selection and support for use of long-acting bronchodilators, were similar across treatment guidelines. There were differences in measures used for stratification of disease severity, consideration of patient phenotypes, criteria for the use of inhaled corticosteroids and recommendations for other medications (e.g. theophylline and mucolytics) in addition to bronchodilators.There is generally good agreement on treatment goals, criteria for diagnosis of COPD and use of long-acting bronchodilators as the cornerstone of treatment among guidelines for COPD management in Europe and Russia. However, there are differences in the definitions of patient subgroups and other recommended treatments.
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A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA School of Business and Economics
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A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA School of Business and Economics
BIM-lean synergies in the management on MEP works in public facilities of intensive use a case study
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21st Annual Conference of the International Group for Lean Construction IGLC 21 Fortaleza, Brazil
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A Work Project, presented as part of the requirements for the Award of a Masters Degree in Finance from the NOVA School of Business and Economics
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Tese apresentada como requisito parcial para obteno do grau de Doutor em Gesto de Informao
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The purpose of this paper is to conduct a methodical drawback analysis of a financial supplier risk management approach which is currently implemented in the automotive industry. Based on identified methodical flaws, the risk assessment model is further developed by introducing a malus system which incorporates hidden risks into the model and by revising the derivation of the most central risk measure in the current model. Both methodical changes lead to significant enhancements in terms of risk assessment accuracy, supplier identification and workload efficiency.
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Enterprise Risk Management (ERM) is gaining relevance among financial and non-financial companies but its benefits still are uncertain. This paper aims at investigating the relationship between ERM adoption and firm performance based on a sample of 1130 non-financial companies belonging to the STOXX index. A content analysis of individual accounts is performed to distinguish adopters, and a regression analysis explores the effect of ERM adoption on firm performance, proxied by Tobins Q. The findings suggest that there is a statistical significant positive effect of ERM adoption on firm performance, meaning that firms are benefiting from the implementation of this process.
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AZero waste management is believed to be one of methods to gain sustainability in urban areas. Take advantages of resources as enough as the needs and process it until the last part to be wasted is a contribution to take care the environment for the next generation. Reduce, reuse, and recycle are three simplesactivities which are until nowadays consideredas the back bone of zero waste. Jonggolgreen city is a new urban area in Indonesia with a 100 ha of surface area zoned as education tourism area. It is an independent area with pure natural resources of water, air, and land to be managed and protected. It is planned as green city through zero waste management since2013. In this preliminary period, a monitoring tool is being prepared by applying a Life Cycle Analysis (LCA) for urban areas [1]. This paper will present an explanatory assessment ofthe zero waste management for Jonggolgreen city. The existing situation will be examined through LCA and afterwards,the new program and the proposed green design to gain the next level of zero waste will be discussed. The purpose is to track the persistence of the commitment and the perception of the necessary innovationsin order to achieve the ideal behavior level of LCA.
