Use of Biological Motion based Cues and Ecological Sounds in the Neurorehabilitation of Apraxia

Technological progress in the area of informatics and human interface platforms create a window of opportunities for the neurorehablitation of patients with motor impairments. The CogWatch project (www.cogwatch.eu) aims to create an intelligent assistance system to improve motor planning and execution in patients with apraxia during their daily activities. Due to the brain damage caused by cardiovascular incident these patients suffer from impairments in the ability to use tools, and to sequence actions during daily tasks (such as making breakfast). Based on the common coding theory (Hommel et al., 2001) and mirror neuron primate research (Rizzolatti et al., 2001) we aim to explore use of cues, which incorporate aspects of biological motion from healthy adults performing everyday tasks requiring tool use and ecological sounds linked to the action goal. We hypothesize that patients with apraxia will benefit from supplementary sensory information relevant to the task, which will reinforce the selection of the appropriate motor plan. Findings from this study determine the type of sensory guidance in the CogWatch interface. Rationale for the experimental design is presented and the relevant literature is discussed.

Metodología de Diseño y Análisis de Sistemas Teleoperados Considerando Dinámica No Lineal

Cuando la separación física entre el sistema local y remoto es relativamente corta, el retardo no es perceptible; sin embargo, cuando el manipulador local y el manipulador remoto se encuentran a una distancia lejana uno del otro, el retardo de tiempo ya no es insignificante e influye negativamente en la realización de la tarea. El retardo de tiempo en un sistema de control introduce un atraso de fase que a su vez degrada el rendimiento del sistema y puede causar inestabilidad. Los sistemas de teleoperación pueden sacar provecho de la posibilidad de estar presente en dos lugares simultáneamente, sin embargo, el uso de Internet y otras redes de conmutación de paquetes, tales como Internet2, impone retardos de tiempo variables, haciendo que los esquemas de control ya establecidos elaboren soluciones para hacer frente a inestabilidades causadas por estos retardos de tiempo variables. En este trabajo de tesis se presenta el modelado y análisis de un sistema de teloperación bilateral no lineal de n grados de libertad controlado por convergencia de estado. La comunicación entre el sitio local y remoto se realiza mediante un canal de comunicación con retardo de tiempo. El análisis presentado en este trabajo considera que el retardo puede ser constante o variable. Los principales objetivos de este trabajo son; 1) Desarrollar una arquitectura de control no lineal garantizando la estabilidad del sistema teleoperado, 2) Evaluar la estabilidad del sistema considerando el retardo en la comunicación, y 3) Implementación de los algoritmos desarrollados para probar el desempeño de los mismos en un sistema experimental de 3 grados de libertad. A través de la teoría de Estabilidad de Lyapunov y el funcional Lyapunov-Krasovskii, se demuestra que el sistema de lazo cerrado es asintóticamente estable. Estas conclusiones de estabilidad se han obtenido mediante la integración de la función de Lyapunov y aplicando el Lema de Barbalat. Se demuestra también que se logra sincronizar las posiciones del manipulador local y remoto cuando el operador humano no mueve el manipulador local y el manipulador remoto se mueve libremente. El esquema de control propuesto se ha validado mediante simulación y en forma experimental empleando un sistema de teleoperación real desarrollado en esta tesis doctoral y que consta de un un manipulador serie planar de tres grados de libertad, un manipulador local, PHANTOM Omni, el cual es un dispositivo haptico fabricado que consta de 3 grados de libertad (en fuerza) y que proporciona realimentación de fuerza en los ejes x,y,z. El control en tiempo real se ha diseñado usando el Sistema Operativo en Tiempo Real QuaRC de QUARC en el lado local y el Simulink Real-Time Windows TargetTM en el lado remoto. Para finalizar el resumen se destaca el impacto de esta tesis en el mundo científico a través de los resultados publicados: 2 artículos en revistas con índice de impacto , 1 artículo en una revista indexada en Sistemas, Cibernética e Informática, 7 artículos en congresos y ha obtenido un premio en la 9a. Conferencia Iberoamericana en Sistemas, Cibernética e Informática, 2010. ABSTRACT When the physical separation between the local and remote system is relatively short, the delay is not noticeable; however, when the local manipulator and the remote manipulator are at a far distance from each other, the time delay is no longer negligible and negatively influences the performance of the task. The time delay in a control system introduces a phase delay which in turn degrades the system performance and cause instability. Teleoperation systems can benefit from the ability to be in two places simultaneously, however, the use of Internet and other packet switched networks, such as Internet2, imposes varying time delays, making established control schemes to develop solutions to address these instabilities caused by different time delays. In this thesis work we present a modeling and analysis of a nonlinear bilateral teloperation system of n degrees of freedom controlled by state convergence strategy. Communication between the local and remote site is via a communication channel with time delay. The analysis presented in this work considers that the time-delay can be constant or variable. The main objectives of this work are; 1) Develop a nonlinear control schemes to ensure the stability of the teleoperated system, 2) Evaluate the system stability considering the delay in communication, and 3) Implementation of algorithms developed to test the performance of the teleoperation system in an experimental system of 3 degrees of freedom. Through the Theory of Stability of Lyapunov and the functional Lyapunov-Krasovskii, one demonstrates that the closed loop system is asymptotically stable.. The conclusions about stability were obtained by integration of the Lyapunov function and applying Barbalat Lemma. It further shows that the positions of the local and remote manipulator are synchronize when the human operator stops applying a constant force and the remote manipulator does not interact with the environment. The proposed control scheme has been validated by means of simulation and in experimental form using a developed system of real teleoperation in this doctoral thesis, which consists of a series planar manipulator of three degrees of freedom, a local manipulator, PHANTOM Omni, which is an haptic device that consists of 3 degrees of freedom (in force) and that provide feeback force in x-axis, and, z. The control in real time has been designed using the Operating system in Real time QuaRC of Quanser in the local side and the Simulink Real-Time Windows Target in the remote side. In order to finalize the summary, the highlights impact of this thesis in the scientific world are shows through the published results: 2 articles in Journals with impact factor, one article in a indexed Journal on Systemics, Cybernetics and Informatics, 7 articles in Conferences and has won an award in 9a. Conferencia Iberoamericana en Sistemas, Cibernética e Informática, 2010.

Recuperación cruzada de información pública clínico-genómica a partir de consultas sobre repositorios clínicos privados

Parte de la investigación biomédica actual se encuentra centrada en el análisis de datos heterogéneos. Estos datos pueden tener distinto origen, estructura, y semántica. Gran cantidad de datos de interés para los investigadores se encuentran en bases de datos públicas, que recogen información de distintas fuentes y la ponen a disposición de la comunidad de forma gratuita. Para homogeneizar estas fuentes de datos públicas con otras de origen privado, existen diversas herramientas y técnicas que permiten automatizar los procesos de homogeneización de datos heterogéneos. El Grupo de Informática Biomédica (GIB) [1] de la Universidad Politécnica de Madrid colabora en el proyecto europeo P-medicine [2], cuya finalidad reside en el desarrollo de una infraestructura que facilite la evolución de los procedimientos médicos actuales hacia la medicina personalizada. Una de las tareas enmarcadas en el proyecto P-medicine que tiene asignado el grupo consiste en elaborar herramientas que ayuden a usuarios en el proceso de integración de datos contenidos en fuentes de información heterogéneas. Algunas de estas fuentes de información son bases de datos públicas de ámbito biomédico contenidas en la plataforma NCBI [3] (National Center for Biotechnology Information). Una de las herramientas que el grupo desarrolla para integrar fuentes de datos es Ontology Annotator. En una de sus fases, la labor del usuario consiste en recuperar información de una base de datos pública y seleccionar de forma manual los resultados relevantes. Para automatizar el proceso de búsqueda y selección de resultados relevantes, por un lado existe un gran interés en conseguir generar consultas que guíen hacia resultados lo más precisos y exactos como sea posible, por otro lado, existe un gran interés en extraer información relevante de elevadas cantidades de documentos, lo cual requiere de sistemas que analicen y ponderen los datos que caracterizan a los mismos. En el campo informático de la inteligencia artificial, dentro de la rama de la recuperación de la información, existen diversos estudios acerca de la expansión de consultas a partir de retroalimentación relevante que podrían ser de gran utilidad para dar solución a la cuestión. Estos estudios se centran en técnicas para reformular o expandir la consulta inicial utilizando como realimentación los resultados que en una primera instancia fueron relevantes para el usuario, de forma que el nuevo conjunto de resultados tenga mayor proximidad con los que el usuario realmente desea. El objetivo de este trabajo de fin de grado consiste en el estudio, implementación y experimentación de métodos que automaticen el proceso de extracción de información trascendente de documentos, utilizándola para expandir o reformular consultas. De esta forma se pretende mejorar la precisión y el ranking de los resultados asociados. Dichos métodos serán integrados en la herramienta Ontology Annotator y enfocados a la fuente de datos de PubMed [4].---ABSTRACT---Part of the current biomedical research is focused on the analysis of heterogeneous data. These data may have different origin, structure and semantics. A big quantity of interesting data is contained in public databases which gather information from different sources and make it open and free to be used by the community. In order to homogenize thise sources of public data with others which origin is private, there are some tools and techniques that allow automating the processes of integration heterogeneous data. The biomedical informatics group of the Universidad Politécnica de Madrid cooperates with the European project P-medicine which main purpose is to create an infrastructure and models to facilitate the transition from current medical practice to personalized medicine. One of the tasks of the project that the group is in charge of consists on the development of tools that will help users in the process of integrating data from diverse sources. Some of the sources are biomedical public data bases from the NCBI platform (National Center for Biotechnology Information). One of the tools in which the group is currently working on for the integration of data sources is called the Ontology Annotator. In this tool there is a phase in which the user has to retrieve information from a public data base and select the relevant data contained in it manually. For automating the process of searching and selecting data on the one hand, there is an interest in automatically generating queries that guide towards the more precise results as possible. On the other hand, there is an interest on retrieve relevant information from large quantities of documents. The solution requires systems that analyze and weigh the data allowing the localization of the relevant items. In the computer science field of the artificial intelligence, in the branch of information retrieval there are diverse studies about the query expansion from relevance feedback that could be used to solve the problem. The main purpose of this studies is to obtain a set of results that is the closer as possible to the information that the user really wants to retrieve. In order to reach this purpose different techniques are used to reformulate or expand the initial query using a feedback the results that where relevant for the user, with this method, the new set of results will have more proximity with the ones that the user really desires. The goal of this final dissertation project consists on the study, implementation and experimentation of methods that automate the process of extraction of relevant information from documents using this information to expand queries. This way, the precision and the ranking of the results associated will be improved. These methods will be integrated in the Ontology Annotator tool and will focus on the PubMed data source.

Analysis of air flow past and through the 2415-3S airfoil for an unmanned aerial vehicle with internal propulsion system

This paper deals with the prediction of velocity fields on the 2415-3S airfoil which will be used for an unmanned aerial vehicle with internal propulsion system and in this way analyze the air flow through an internal duct of the airfoil using computational fluid dynamics. The main objective is to evaluate the effect of the internal air flow past the airfoil and how this affects the aerodynamic performance by means of lift and drag forces. For this purpose, three different designs of the internal duct were studied; starting from the base 2415-3S airfoil developed in previous investigation, basing on the hypothesis of decreasing the flow separation produced when the propulsive airflow merges the external flow, and in this way obtaining the best configuration. For that purpose, an exhaustive study of the mesh sensitivity was performed. It was used a non-structured mesh since the computational domain is three-dimensional and complex. The selected mesh contains approximately 12.5 million elements. Both the computational domain and the numerical solution were made with commercial CAD and CFD software, respectively. Air, incompressible and steady was analyzed. The boundary conditions are in concordance with experimental setup in the AF 6109 wind tunnel. The k-e model is utilized to describe the turbulent flow process as followed in references. Results allowed obtaining velocity contours as well as lift and drag coefficients and also the location of separation and reattachment regions in some cases for zero degrees of angle of attack on the internal and external surfaces of the airfoil. Finally, the selection of the configuration with the best aerodynamic performance was made, selecting the option without curved baffles.

Espacio web para el diseño de un museo virtual de la historia de la informática

El objetivo principal de crear un espacio web para el Museo Histórico de la Informática (MHI) perteneciente a la Escuela Técnica Superior de Ingenieros Informáticos (ETSIINF) de la Universidad Politécnica de Madrid (UPM) es la difusión de la historia de la informática entre el público en general. Si bien es cierto que existe ya una página web de consulta del MHI con algunas imágenes y contenido sobre los objetos que allí se exhiben, es también reseñable que se trata de un espacio obsoleto, lleno de carencias y extremadamente difícil de gestionar y actualizar, por lo que se hacía imprescindible actualizar el diseño del espacio web, los contenidos y el sistema de gestión de los mismos, cosa que es de gran interés para un lugar divulgativo. En la actualidad, existen maneras mucho más amigables para el usuario de navegar por una web; y de la misma manera para un administrador, gestionar el contenido de la misma y mantener a los usuarios bien informados de todo lo que se ofrece en cada momento. Esto es posible gracias a los sistemas de gestión de contenidos o content management system (CMS), de los que se hablará lo largo de todo el documento. Estos sistemas, dan una facilidad mucho mayor a los encargados de llevar al día una página web, sin tener que saber de programación, lenguajes o informática en general, ya que incorporan paneles de control muy intuitivos y fáciles de manejar, que son una ventaja tanto para ellos como para los usuarios. Es por esta razón que, hay páginas web como la de las empresas IKEA, Ubuntu o, en especial para el caso que compete al documento, el museo del Louvre usan gestores de contenidos para sus páginas web. Y es que las ventajas y facilidades que ofrece un CMS son realmente interesantes y se tratará de todas ellas en el documento, de la elección del CMS que mejor se ajusta a los requisitos del museo, las restricciones a la hora del despliegue en el ámbito de la ETSIINF y de cómo mejorará esto la calidad visual y divulgativa del MHI. Este trabajo se desarrolla a lo largo de 11 capítulos, en los que se muestra como construir un sitio web, las posibilidades y la elección final para este caso. En el primer capítulo se hace una pequeña introducción de lo que es el proyecto, se especifican los objetivos, la motivación del mismo y el alcance que tiene. En el segundo capítulo se muestra la información que se ha recopilado en el trabajo de investigación que se hace previo al desarrollo. En él se muestran los distintos tipos de páginas web, que tecnologías y lenguajes se pueden usar para su construcción, una comparativa sobre otras entidades similares al MHI, las limitaciones que presenta el entorno y la elección final que se consideró más adecuada para este caso. En el capítulo tres se empieza a desarrollar la solución a través del diseño. Aquí se puede encontrar el diseño de más bajo nivel que se le presenta al cliente para sentar las bases del trabajo, el diseño de alto nivel con un mayor grado de realidad que el anterior y una preparación de lo que serán los planes de prueba. El capítulo cuatro muestra todo lo que se ha usado en la implementación y la integración de la página web: herramientas, tecnologías, plantillas de diseño y módulos que proporcionan distintas funcionalidades. Llegados al capítulo cinco, se puede ver una detallada documentación de los resultados de las pruebas de usabilidad y accesibilidad realizadas, y las conclusiones que subyacen de estas. Una vez acabada la implementación del sitio web del MHI, en el capítulo seis se intenta hacer una labor de consultoría, mostrando precios y presupuestos de las distintas tareas que se han llevado a cabo para la realización de este proyecto. En el capítulo siete se extraen las conclusiones de todo lo acontecido en los capítulos anteriores y en el ocho unas líneas sobre posibles trabajos futuros que se podrían llevar a cabo en base a lo que ya se tiene en la institución, incluido este trabajo. Para facilitar la comprensión y satisfacer la curiosidad del lector, se ha incluido en el capítulo nueve la bibliografía con toda la documentación consultada y en el diez un glosario de términos para la aclaración de términos y acrónimos más técnicos. Para acabar, en el capítulo once se anexionan tanto el documento que se usó para las pruebas de usabilidad como un manual de administrador para el sitio web, que hace más amigable el entorno para las personas que lo tengan que mantener en un futuro.---ABSTRACT---The main goal of creating a website for the Informatics Historical Museum (“Museo Histórico de la Informática” or MHI) located in the Higher Technical School of Informatics Engineers (“Escuela Técnica Superior de Ingenieros Informáticos” or ETSIINF) of the Polytechnic University of Madrid (“Universidad Politécnica de Madrid” UPM), is to promote the aforementioned museum as to increase its reach to the public. While it is true that there already is a consulting website with some pictures and information about the items which are displayed in the building, it is outdated and the data is scarce. Moreover, it is extremely complicated to manage and to regularly update the web page, which is very important for informative/broadcasting media. Currently, there are easier ways for the users of a website to consult whatever information they want, as well as it is now easy for a website manager to display new content and to keep the users informed about what is been offered at every moment. This is possible because of content management systems (CMS), which will be discussed throughout the entire paper. These systems make it easier to use for the administrator of a website to keep it up to date without the necessity for them of having any knowledge or skills in programming, languages or computing, because the systems have an intuitive control panel that is easy to use, which is an advantage for both managers and users. Because of all these reasons, there are lots of companies that use this kind of systems, such as IKEA, Ubuntu or, especially, the Louvre Museum, to which we direct our attention all throughout this report. It is easy to notice that these systems have an important and very interesting number of perks and benefits. In the next chapters of the document we will explain the benefits of the program as well as the choice on the kind of CMS that best suits the requirements of the museum and, finally, the restrictions of the school for the deployment and of how all of this will improve the visual and informational qualities of the MHI. This work is developed over 11 chapters, shown how to build up a website, the possibilities and the final choice for this case. In the first chapter a brief introduction of the project, goals, motivation and scope thereof having specified are done. Before the development of the website, the second chapter shows de information of the researching work. It discusses the different types of websites, technologies and languages that can be used for build-up, a comparison of similar entities to MHI, the limitations of the environment and the final choice was considered more appropriate for this case. Chapter three begins to develop the design of the solution. Here there are the lowest level design that presents the customer to fix any problem, the high level design with a higher degree of reality than the last and the test plans. Chapter four shows everything that has been used in the implementation and integration of the website: tools, technologies, design templates and modules that provide different functionalities. Reaching the fifth chapter, you can see a detailed documentation of the results of the usability and accessibility tests made to some users and the conclusions of it. Once the implementation of MHI website is done, in chapter six there is a consultancy work, showing prices and budgets of the different tasks which were carried out for this project. In chapter seven there are the conclusions of what happened in the previous chapters and eight chapter shows possible future works that could be carried out based on what the institution already have, including this work. To make easier to the reader understand this paper and satisfy his curiosity, the chapter nine includes the bibliography consulted with all the documentation and chapter ten has a glossary of terms and an explanation of technical terms and acronyms. Finally, in chapter eleven there are attached both the document that was used for usability testing as a manual administrator for the website, making the environment friendlier for people who have to maintain it in the future.

Herramienta EN 301 549: cliente web

En el año 2014 se publicó, bajo mandato de la Comisión Europea, la Norma Europea EN 301 549, titulada “Requisitos de accesibilidad de productos y servicios TIC aplicables a la contratación pública en Europa”. El objetivo de dicha norma es que los productos o servicios TIC (Tecnologías de la Información y la Comunicación) adquiridos por cualquier administración pública europea puedan ser utilizados por personas con diversas características y capacidades, incluyendo a personas con discapacidad. La norma EN 301 549 es compleja, ya que contiene más de 200 requisitos y recomendaciones, que se aplican o no a un producto o servicio TIC en función de las características de dicho producto o servicio. Por ello se ha planteado, desde el Grupo de Investigación en Tecnología Informática y de las Comunicaciones (CETTICO), el desarrollo de una herramienta de soporte a la evaluación del cumplimiento de la norma. La herramienta permitirá a grupos de trabajo anotar los resultados de la evaluación de accesibilidad de un producto o servicio TIC siguiendo los requisitos de la norma Europea EN 301 549. Este trabajo de Fin de Grado se centra en el diseño y codificación del cliente web de la herramienta. Se parte de los resultados de un TFG y un practicum anteriores. En el TFG realizado por Laura Elorrieta [Elorrieta, 2014], se diseñó la interacción del sistema y se evaluó su grado de usabilidad. En el practicum [Montero, 2015], posterior al TFG de Laura Elorrieta, se eligieron las tecnologías web que se iban a utilizar y se realizó el diseño y la implementación mediante prototipos iterativos de la gestión de proyectos de evaluación. El trabajo que se ha realizado en el TFG ha consistido en el diseño de la interfaz de usuario analizando los cambios a realizar en el diseño, debido a los errores de usabilidad conocidos, y la implementación del prototipo funcional de la herramienta. Junto con la parte servidor del TFG de mi compañero Rubén Ortiz Burgos y la interfaz de usuario de este TFG se ha obtenido una aplicación web para realizar evaluaciones de accesibilidad de productos o servicios TIC siguiendo los requisitos de la norma EN 301 549. El prototipo funcional contiene diez páginas web que recogen las diferentes acciones y tareas que pueden realizar los usuarios en función del rol que desempeñen. EL diseño y la implementación se han llevado a cabo empleando las tecnologías web HTML5, CSS3, JavaScript, jQuery y las librerías de Foundation frontend framework.---ABSTRACT---In 2014, under the European Commission mandate, the European standard EN 301 549 has been published under the title “Accessibility requirements applicable to ICT products and procurement services in Europe”. The goal of this standard is that the products or services ICT (Information Communication Technology) acquires by every European public administration can be used by every person with different characteristics and capacities, including those with disability. The rule EN 301549 is very complex, since it has more than 200 requirements and recommendations that can be or not applied to an ICT product or service based on its characteristics of the given product or service. That’s why a development of a support tool has been proposed to the rating of the compliance of the rule, by the Research Group of Informatics Technology and Communication. This tool will allow working groups to record the results of the compliance of accessibility of a product or service following the requirements of the European Standard EN 301549. This Final Degree Work focuses in the design and the coding of the web customer of this tool. The results of a TFG and previous practicums have been used for this. The TFG performed by Laura Elorrieta [Elorrieta, 2014], the interaction of the system was designed and degree of usability was evaluated. In the practicum [Montero, 2015], after the TFG Laura Elorrieta, web technologies used were chosen and the design and implementation were performed using iterative prototyping project management evaluation. The work done on the TFG was to design the users interface to perform analyzing changes in design due to errors known usability and working prototype implementation of the tool. Together with the server part of the TFG my partner Rubén Ortiz Burgos and the user interface done of this TFG it has obtained a web application for the conduct of evaluations accessibility of products or services ICT following the requirements of the EN 301 549. The functional prototype contains ten web sites that collect the various activities and tasks that users can perform based on the role they perform. The design and implementation have been carried out using the technologies web HTML5, CSS3, Java Script, jQuery and the libraries of Foundation fronted framework.

On the Velocity and Acceleration Estimation from Discrete Time-Position Sensors

In this work is addressed the topic of estimation of velocity and acceleration from digital position data. It is presented a review of several classic methods and implemented with real position data from a low cost digital sensor of a hydraulic linear actuator. The results are analyzed and compared. It is shown that static methods have a limited bandwidth application, and that the performance of some methods may be enhanced by adapting its parameters according to the current state.

TV REGIONAL NO VALE DO PARAÍBA - SP: expansão, aspectos da audiência e modos de inserção local

Investigação sobre a regionalização das redes de comunicação, em especial a televisão, fenômeno que representa uma realidade de segmentação da comunicação massiva. Objetiva-se analisar e classificar as emissoras regionais de televisão com relação aos seus modos de inserção local, observando-se suas especificidades, programação, estratégias de comunicação e ações de conquista de identidade com a comunidade onde estão inseridas, além de tentar compreender como se deu a expansão da televisão nessa região, desde a implantação da primeira emissora, em 1988, na cidade de São José dos Campos SP. Tomando-se como recorte de estudo, as emissoras de televisão regional de sinal aberto no Vale do Paraíba, estado de São Paulo, foram realizadas entrevistas semi-abertas com profissionais das áreas comercial e de programação das mesmas e aplicados questionários junto a uma amostra da população do Vale do Paraíba que representa os telespectadores potenciais da área de cobertura dessas emissoras, a fim de se identificar a percepção que o público receptor tem a respeito da presença e atuação das televisões locais. Conclui-se que os diferentes modos de inserção local das emissoras influem diretamente na relação de identidade das mesmas com os telespectadores da região.(AU)

TV REGIONAL NO VALE DO PARAÍBA - SP: expansão, aspectos da audiência e modos de inserção local

Investigação sobre a regionalização das redes de comunicação, em especial a televisão, fenômeno que representa uma realidade de segmentação da comunicação massiva. Objetiva-se analisar e classificar as emissoras regionais de televisão com relação aos seus modos de inserção local, observando-se suas especificidades, programação, estratégias de comunicação e ações de conquista de identidade com a comunidade onde estão inseridas, além de tentar compreender como se deu a expansão da televisão nessa região, desde a implantação da primeira emissora, em 1988, na cidade de São José dos Campos SP. Tomando-se como recorte de estudo, as emissoras de televisão regional de sinal aberto no Vale do Paraíba, estado de São Paulo, foram realizadas entrevistas semi-abertas com profissionais das áreas comercial e de programação das mesmas e aplicados questionários junto a uma amostra da população do Vale do Paraíba que representa os telespectadores potenciais da área de cobertura dessas emissoras, a fim de se identificar a percepção que o público receptor tem a respeito da presença e atuação das televisões locais. Conclui-se que os diferentes modos de inserção local das emissoras influem diretamente na relação de identidade das mesmas com os telespectadores da região.(AU)

KDIGO-based acute kidney injury criteria operate differently in hospitals and the community—findings from a large population cohort

ACKNOWLEDGEMENTS We acknowledge the data management support of Grampian Data Safe Haven (DaSH) and the associated financial support of NHS Research Scotland, through NHS Grampian investment in the Grampian DaSH. S.S. is supported by a Clinical Research Training Fellowship from the Wellcome Trust (Ref 102729/Z/13/Z). We also acknowledge the support from The Farr Institute of Health Informatics Research. The Farr Institute is supported by a 10-funder consortium: Arthritis Research UK, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council, the National Institute of Health Research, the National Institute for Social Care and Health Research (Welsh Assembly Government), the Chief Scientist Office (Scottish Government Health Directorates) and the Wellcome Trust (MRC Grant Nos: Scotland MR/K007017/1).

Web-based access to mouse models of human cancers: the Mouse Tumor Biology (MTB) Database

The Mouse Tumor Biology (MTB) Database serves as a curated, integrated resource for information about tumor genetics and pathology in genetically defined strains of mice (i.e., inbred, transgenic and targeted mutation strains). Sources of information for the database include the published scientific literature and direct data submissions by the scientific community. Researchers access MTB using Web-based query forms and can use the database to answer such questions as ‘What tumors have been reported in transgenic mice created on a C57BL/6J background?’, ‘What tumors in mice are associated with mutations in the Trp53 gene?’ and ‘What pathology images are available for tumors of the mammary gland regardless of genetic background?’. MTB has been available on the Web since 1998 from the Mouse Genome Informatics web site (http://www.informatics.jax.org). We have recently implemented a number of enhancements to MTB including new query options, redesigned query forms and results pages for pathology and genetic data, and the addition of an electronic data submission and annotation tool for pathology data.

The Mouse Genome Database (MGD): integration nexus for the laboratory mouse

The Mouse Genome Database (MGD) is the community database resource for the laboratory mouse, a key model organism for interpreting the human genome and for understanding human biology and disease (http://www.informatics.jax.org). MGD provides standard nomenclature and consensus map positions for mouse genes and genetic markers; it provides a curated set of mammalian homology records, user-defined chromosomal maps, experimental data sets and the definitive mouse ‘gene to sequence’ reference set for the research community. The integration and standardization of these data sets facilitates the transition between mouse DNA sequence, gene and phenotype annotations. A recent focus on allele and phenotype representations enhances the ability of MGD to organize and present data for exploring the relationship between genotype and phenotype. This link between the genome and the biology of the mouse is especially important as phenotype information grows from large mutagenesis projects and genotype information grows from large-scale sequencing projects.

The Mouse Gene Expression Database (GXD)

The Gene Expression Database (GXD) is a community resource of gene expression information for the laboratory mouse. By combining the different types of expression data, GXD aims to provide increasingly complete information about the expression profiles of genes in different mouse strains and mutants, thus enabling valuable insights into the molecular networks that underlie normal development and disease. GXD is integrated with the Mouse Genome Database (MGD). Extensive interconnections with sequence databases and with databases from other species, and the development and use of shared controlled vocabularies extend GXD’s utility for the analysis of gene expression information. GXD is accessible through the Mouse Genome Informatics web site at http://www.informatic s.jax.org/ or directly at http://www.informatics.jax.org/me nus/expression_menu.shtml.

Is routine hospital episode data sufficient for identifying individuals with chronic kidney disease? : A comparison study with laboratory data

© The Author(s) 2014. Acknowledgements We thank the Information Services Division, Scotland, who provided the SMR01 data, and NHS Grampian, who provided the biochemistry data. We also thank the University of Aberdeen’s Data Management Team. Funding This work was supported by the Chief Scientists Office for Scotland (grant no. CZH/4/656).

Diversificação de espécies e da morfologia em serpentes da família Viperidae: padrões e processos

A diversidade de espécies e fenotípica pode variar consideravelmente entre grupos taxonômicos e ao longo do tempo em uma mesma linhagem. O estudo de tais variações tornou-se um dos principais objetivos da biologia evolutiva fornecendo informações importantes a respeito dos possíveis mecanismos que regulam a biodiversidade. Dessa forma, o objetivo geral da presente tese foi investigar os padrões da diversificação de espécies e da morfologia em um grupo cosmopolita de serpentes, a família Viperidae, e os potenciais processos subjacentes. Primeiramente, (1) reconstruímos as relações filogenéticas e estimamos os tempos de divergência entre as linhagens da família Viperidae utilizando uma abordagem Bayesiana. (2) Aplicando um método recentemente desenvolvido (BAMM), exploramos como as taxas de especiação e extinção variaram ao longo da radiação do grupo inferindo os possíveis processos reguladores. Por fim, (3) analisamos se a evolução do tamanho do corpo e as taxas de especiação variam nos diferentes habitats ocupados pelos viperídeos (terrestres vs arborícola). Nesta tese geramos a filogenia molecular de viperídeos mais completa até o momento utilizando sequências para 11 genes mitocondriais e nucleares abrangendo 79% das espécies viventes (264 terminais) e todos com exceção de um gênero. De maneira geral, foi possível obter relações filogenéticas robustas para o grupo com a maioria dos gêneros sendo monofilética. Os tempos de divergência obtidos indicam que os viperídeos começaram a diversificar em meados do Paleoceno tardio/meio do Eoceno inferindo idades um pouco mais tardias que o encontrado em estudos anteriores. Durante a radiação do grupo, um aumento nas taxas de especiação parece ter ocorrido durante a diversificação dos crotalíneos (pit vipers) em decorrência não só da evolução das fossetas loreais mas também como resultado de mudanças geológicas e climáticas na Ásia e da invasão do novo mundo. Após este rápido aumento inicial, as taxas de especiação desaceleraram em direção ao presente. Por fim, os resultados aqui apresentados indicam que apesar dos habitats arborícolas limitarem a evolução morfológica nos viperídeos, a evolução da arborealidade parece não afetar as taxas de especiação que permanecem similares entre linhagens arborícolas e terrestres. Isto sugere dois cenários: (1) a especiação acontece de forma independente das mudanças morfológicas nos viperídeos; ou (2) o isolamento geográfico seria um mecanismo importante na diversificação de linhagens arborícolas contrabalançando decréscimos nas oportunidades de especiação possivelmente relacionados às pressões seletivas impostas pelo ambiente arborícola. A presente tese contribui para entendermos mais sobre como evoluíram os viperídeos ao longo dos seus ∼50 milhões de anos. Além de propor cenários e hipóteses a serem futuramente explorados com os viperídeos, elaboramos uma discussão ampla e conceitual a respeito dos possíveis mecanismos por trás da diversificação de espécies e da morfologia que poderiam também ser contemplados para outros grupos de organismos. Portanto, a presente tese contribui não só para entendermos os mecanismos que geram e mantém a diversidade de serpentes, mas também para enriquecer a discussão dos mecanismos que geram e mantém a biodiversidade como um todo