1000 resultados para Alexander J. Grant -- Welland Canal, Ontario
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1881/08/01 (N20,VOL2)-1881/08/31.
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1880/03/01 (N3,VOL1)-1880/03/31.
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1880/05/01 (N5,VOL1)-1880/05/31.
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Périodicité : Mensuel
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1881/06/01 (N18,VOL2)-1881/06/30.
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1881/09/01 (N21,VOL2)-1881/09/30.
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1881/10/01 (N22,VOL2)-1881/10/31.
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1880/02/01 (N2,VOL1)-1880/02/28.
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1880/10/01 (N10,VOL1)-1880/10/31.
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1881/03/01 (N15,VOL2)-1881/03/31.
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1881/07/01 (N19,VOL2)-1881/07/31.
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1880/12/01 (N12,VOL1)-1880/12/31.
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1880/11/01 (N11,VOL1)-1880/11/30.
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1880/08/01 (N8,VOL1)-1880/08/31.
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Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.