Reseña de 'Problemas fundamentales de la gramática del español como 2/L', de María Luz Gutiérrez Araus

'Problemas fundamentales de la gramática del español como 2/L' es un volumen que apreciarán y agradecerán todos aquellos profesores o futuros profesores y aprendices de nivel superior que cuenten con un bagaje formativo filológico-lingüístico, ya que el metalenguaje que se emplea en las explicaciones y en los epígrafes hará sentir cómodo y seguro a este tipo de lector, hispanista, ya acostumbrado a reflexionar sobre la lengua española pero que necesita aprender a analizarla desde la perspectiva de quien no la tiene como lengua materna.

SDF 1-alpha (CXCL12) triggers glutamate exocytosis from astrocytes on a millisecond time scale: Imaging analysis at the single-vesicle level with TIRF microscopy

Chemokines are small chemotactic molecules widely expressed throughout the central nervous system. A number of papers, during the past few years, have suggested that they have physiological functions in addition to their roles in neuroinflammatory diseases. In this context, the best evidence concerns the CXC-chemokine stromal cell-derived factor (SDF-1alpha or CXCL12) and its receptor CXCR4, whose signalling cascade is also implicated in the glutamate release process from astrocytes. Recently, astrocytic synaptic like microvesicles (SLMVs) that express vesicular glutamate transporters (VGLUTs) and are able to release glutamate by Ca(2+)-dependent regulated exocytosis, have been described both in tissue and in cultured astrocytes. Here, in order to elucidate whether SDF-1alpha/CXCR4 system can participate to the brain fast communication systems, we investigated whether the activation of CXCR4 receptor triggers glutamate exocytosis in astrocytes. By using total internal reflection (TIRF) microscopy and the membrane-fluorescent styryl dye FM4-64, we adapted an imaging methodology recently developed to measure exocytosis and recycling in synaptic terminals, and monitored the CXCR4-mediated exocytosis of SLMVs in astrocytes. We analyzed the co-localization of VGLUT with the FM dye at single-vesicle level, and observed the kinetics of the FM dye release during single fusion events. We found that the activation of CXCR4 receptors triggered a burst of exocytosis on a millisecond time scale that involved the release of Ca(2+) from internal stores. These results support the idea that astrocytes can respond to external stimuli and communicate with the neighboring cells via fast release of glutamate.

Construction of a scale to evaluate the diurnal impact of insomnia

The objective of this study was to develop and validate a scale to assess the diurnal impact of insomnia. The Insomnia Diurnal Impact Scale (IDIS) comprises six items designed to evaluate the daytime effects of insomnia. The sychometric properties of the original scale were analysed in a sample of 172 students, while its ability to differentiate insomniacs and non-insomniacs (according to the International Classification of Diseases (ICD)-10 criteria) was examined in a sample of 79 psychiatric patients and 82 individuals from the community. The psychometric properties of the English version were then analysed in a sample of 44 Englishspeaking participants. The results showed the internal consistency coefficient to be very good (0.86), with testretest reliability at 1 month being 0.79. A single factor explained almost 60% of the variance. Correlation of the IDIS with other scales varied between moderate and high values. Sensitivity was 78% and specificity 57% in the community sample, while the corresponding figures for the psychiatric population were 83% and 63%. Cronbach's ¿ coefficient for the English version reached a value of 0.93. These results indicate that the IDIS shows adequate reliability and validity with both general and psychiatric populations, and also that it can discriminate between the presence and absence of insomnia. The English version presents good preliminary results regarding item-corrected total correlation and internal consistency. In conclusion, the IDIS appears to be a useful tool in the primary care and mental health contexts for assessing insomnia-related diurnal dysfunction.

Comparison of Various Commercial Hydrated Limes for Reducing Soil Plasticity, HR-82 and HR-106, 1964

Atterberg limits tests were performed on mixtures of gumbotil soil and the various chief chemical compounds found in hydrated limes. The results were then checked with commercial hydrated limes of varying chemical compositions. Results indicate that among the major constituents of hydrated limes Ca(OH)2 is most effective in reducing soil plasticity. MgO shows a moderate effect, but Mg(OH)2 and CaCO3 show practically no effect. There is, however, practically no difference between different types or between the same type of commercial hydrated limes for the reduction of soil plasticity. The choice of lime for soil-lime stabilization should, therefore, be dictated by the relative price and pozzolanic strength characteristics of the lime.

Rupture d'une hyperplasie nodulaire focale. A propos de deux cas [Rupture of hepatic focal nodular hyperplasia. About two cases]

The diagnostics of focal nodular hyperplasia is reached through the use of imaging. When the diagnostic is certain, surgical abstention is the rule. Nevertheless, we were confronted with two cases of a rare complication; that of intraperitoneal rupture. In this situation, we suggest to first do an arteriography to control the bleeding, then to perform surgery when the patient has reached hemodynamic stability. Spontaneous rupture as a complication of benign nodular hyperplasia remains a rare event and only five cases were reported in litterature.

Enquesta sobre l’ús i la satisfacció de les biblioteques de la UPC per part dels estudiants : curs 2006/07

Per tal de valorar el grau de satisfacció que tenen els estudiants de les biblioteques de la UPC, el Servei de Biblioteques i Documentació elabora amb periodicitat biennal“L’enquesta sobre l’ús i la satisfacció de les biblioteques per part dels estudiants”. La primera enquesta es va realitzar el curs 1994-95, així doncs, els resultats que es presenten en aquest document corresponen a la setena edició.Aquesta enquesta té com a objectiu principal obtenir informació sobre la percepció quetenen de les biblioteques de la UPC els usuaris que les visiten i conèixer així l’ús i el grau de satisfacció dels serveis, les instal·lacions i els recursos bibliogràfics.A partir de l’anàlisi de les dades obtingudes, les biblioteques estableixen propostes que han de comportar una millora dels serveis i les instal·lacions de les biblioteques.

Efeito do conteúdo de água e da compactação do solo na produção de soja

A compactação do solo tem sido fator físico limitante ao crescimento das plantas. Este trabalho objetivou avaliar a produção de soja (Glycine max cv. EMBRAPA 48) em razão do conteúdo de água e da compactação do solo. Usou-se o delineamento inteiramente casualizado, em esquema fatorial 4x2, ou seja, quatro níveis de resistência à penetração (entre 0,27 e 4,32 MPa) e dois níveis de retenção de água pelo solo (0,05 e 0,01 MPa). Foram utilizadas amostras de Latossolo Vermelho textura média (LVd) e Latossolo Vermelho textura argilosa (LVef), coletadas na profundidade de 020 cm, passadas em peneira de 0,4 cm e compactadas em camadas de 3 cm, em vasos de 20 cm de altura e 25 cm de diâmetro (9,82 L). Os níveis de resistência à penetração foram determinados com o penetrômetro de anel dinamométrico. O nível crítico de resistência do solo à penetração, em relação à produção de grãos, foi de 1,66 e 2,22 MPa, no LVd, e 3,05 e 2,81 MPa, no LVef, para o conteúdo de água retida na tensão de 0,05 e 0,01 MPa, respectivamente. A maior produção de grãos foi obtida na tensão de 0,01 MPa. A produção de grãos de soja é afetada em níveis críticos de resistência do solo à penetração superiores a 2 MPa em latossolos com conteúdo de água retida na tensão de 0,01 MPa.

Modelling Bone Mineral Density in Swiss Breast Cancer Patients Treated with Letrozole, Tamoxifen and Sequences of Letrozole and Tamoxifen in the BIG 1-98 Study (SAKK 21/07).

Background: Bone health is a concern when treating early stage breast cancer patients with adjuvant aromatase inhibitors. Early detection of patients (pts) at risk of osteoporosis and fractures may be helpful for starting preventive therapies and selecting the most appropriate endocrine therapy schedule. We present statistical models describing the evolution of lumbar and hip bone mineral density (BMD) in pts treated with tamoxifen (T), letrozole (L) and sequences of T and L. Methods: Available dual-energy x-ray absorptiometry exams (DXA) of pts treated in trial BIG 1-98 were retrospectively collected from Swiss centers. Treatment arms: A) T for 5 years, B) L for 5 years, C) 2 years of T followed by 3 years of L and, D) 2 years of L followed by 3 years of T. Pts without DXA were used as a control for detecting selection biases. Patients randomized to arm A were subsequently allowed an unplanned switch from T to L. Allowing for variations between DXA machines and centres, two repeated measures models, using a covariance structure that allow for different times between DXA, were used to estimate changes in hip and lumbar BMD (g/cm2) from trial randomization. Prospectively defined covariates, considered as fixed effects in the multivariable models in an intention to treat analysis, at the time of trial randomization were: age, height, weight, hysterectomy, race, known osteoporosis, tobacco use, prior bone fracture, prior hormone replacement therapy (HRT), bisphosphonate use and previous neo-/adjuvant chemotherapy (ChT). Similarly, the T-scores for lumbar and hip BMD measurements were modeled using a per-protocol approach (allowing for treatment switch in arm A), specifically studying the effect of each therapy upon T-score percentage. Results: A total of 247 out of 546 pts had between 1 and 5 DXA; a total of 576 DXA were collected. Number of DXA measurements per arm were; arm A 133, B 137, C 141 and D 135. The median follow-up time was 5.8 years. Significant factors positively correlated with lumbar and hip BMD in the multivariate analysis were weight, previous HRT use, neo-/adjuvant ChT, hysterectomy and height. Significant negatively correlated factors in the models were osteoporosis, treatment arm (B/C/D vs. A), time since endocrine therapy start, age and smoking (current vs. never).Modeling the T-score percentage, differences from T to L were -4.199% (p = 0.036) and -4.907% (p = 0.025) for the hip and lumbar measurements respectively, before any treatment switch occurred. Conclusions: Our statistical models describe the lumbar and hip BMD evolution for pts treated with L and/or T. The results of both localisations confirm that, contrary to expectation, the sequential schedules do not seem less detrimental for the BMD than L monotherapy. The estimated difference in BMD T-score percent is at least 4% from T to L.

Compactação do solo e intervalo hídrico ótimo na produtividade de arroz de sequeiro

O objetivo deste trabalho foi determinar o intervalo hídrico ótimo e sua relação com a produtividade de grãos de arroz de sequeiro em um Latossolo Vermelho de textura média. Os tratamentos foram 0, 1, 2, 4 e 6 passadas de um trator, lado a lado, na superfície do solo, com quatro repetições. O delineamento experimental foi inteiramente casualizado. Foram coletadas amostras indeformadas de solo nas camadas de 0,02-0,05, 0,07-0,10 e 0,15-0,18 m para determinação da resistência do solo à penetração, densidade do solo, intervalo hídrico ótimo, densidade do solo crítica e da curva de retenção de água no solo. Em parcelas de 3,6 m² foi semeado arroz de sequeiro (cv. Caiapó) e a sua produtividade foi avaliada em parcelas úteis de 1,80 m². O intervalo hídrico ótimo foi reduzido a partir da densidade do solo de 1,30 Mg m-3 pela resistência do solo à penetração. A partir do valor de 1,82 MPa ocorreu decréscimo da produtividade de arroz. A densidade do solo crítica ao desenvolvimento radicular no intervalo hídrico ótimo foi de 1,63 Mg m-3, equivalente a 1,62 Mg m-3 que foi limitante na produtividade de arroz. O monitoramento da compactação do solo é necessário para prevenir perdas na produtividade de arroz de sequeiro.

Boone County, Township 82 North Range 25 West

Des Moines River Plat Maps.

Boone County, Township 82 North Range 26 West

Des Moines River Plat Maps.

Boone County, Township 82 North Range 27 West

Des Moines River Plat Maps.

Mobilitat laboral, àrees de cohesió i àrees de planificació a Catalunya

La informació sobre el comportament de la mobilitat laboral a Catalunya ha permès l'aplicació de diferents metodologies de definició d'espais funcionals, entre elles el model de cohesió, que intenta determinar àrees urbanes-ciutats reals a Catalunya. En aquestarticle s'analitza l'evolució de la mobilitat laboral entre 1981 i 2001, així com els resultats d'aplicar el model de cohesió a les dades de 2001. També es fa un petit assaig sobre en quina mesura els àmbits de planificació establerts per la legislació territorial i urbanística de Catalunya, que vol donar resposta a aquesta realitat urbana, es corresponen amb aquells altres que s'han determinat a partir del model de cohesió