Infliximabe no tratamento inicial da retocolite ulcerativa moderada e grave. Terapia top down: Relato preliminar

The first option for the treatment of UC is both: salicylates or corticoids. Recently, in late November of 2006, the Brazilian Ministry of Health has approved infliximab (Remicade c, Mantecorp, Brazil) to treat ulcerative colitis. We report the use of infliximab as a first option for the treatment of two patients with severe ulcerative colitis. Case report: Patient 1: AZF, 52 years-old, female, was first diagnosed with UC after history and clinical examination; colonoscopy showed pancolitis with positive biopsy (crypt microabscess). Her Mayo score was 10 (range: 0 to 12/asymptomatic to severe colitis). She received intra venous infusion of infliximab at a dose of 5mg/Kg of body weigh at week 0, 2, 6 and 14. Then, patient was given mesalazine 4.5 g/day for maintenance therapy. Clinical response was defined as a decreased from baseline in the total Mayo score of at least 3 points. At present, patient is asymptomatic with Mayo score of 3 one moth after the last dose of infliximab. Patient 2: MLA, 45 years-old, female was first diagnosed with bloody diarrhea; colonoscopy showed left colitis and the biopsy was positive for ulcerative colitis. Her Mayo score was 9. She was offered and accepted the step down treatment. She was given infliximab 5mg/Kg of body weight at week 0, 2, 6 and 14. After initial treatment with infliximab, she received mesalazine 4.2 g/day. At present, she is asymptomatic with Mayo score of 2 eighteen days after the last dose of infliximab. At our knowledge, this is the first Brazilian report of the use of infliximab as fist-line therapy in ulcerative colitis. Few days after the begging of the infusion, an impressive clinical and colonoscopy improvement was seen in these two patients. Recently, it has been reported the use of infliximab as first-line therapy in pediatric Crohn disease. Infliximab could be a good option in cases of moderate and severe UC to avoid the side effects of the use of high doses of corticoids in patients with moderate and severe UC. However, the question if step-down therapy in ulcerative colitis is better then conventional therapy with salicylates and corticoids needs to be answered by randomized trials.

Search for W H associated production in 5.3 fb(-1) of p(p)over-bar collisions at the Fermilab Tevatron

We present a search for associated production of Higgs and W bosons in pp̄ collisions at a center of mass energy of s=1.96 TeV in 5.3 fb-1 of integrated luminosity recorded by the D0 experiment. Multivariate analysis techniques are applied to events containing one lepton, an imbalance in transverse energy, and one or two b-tagged jets to discriminate a potential WH signal from Standard Model backgrounds. We observe good agreement between data and expected backgrounds, and set an upper limit of 4.5 (at 95% confidence level and for mH=115 GeV) on the ratio of the WH cross section multiplied by the branching fraction of H→bb̄ to its Standard Model prediction, which is consistent with an expected limit of 4.8. © 2011 Elsevier B.V.

Testing extractants for Cu, Fe, Mn, and Zn in tropical soils treated with sewage sludge for 13 consecutive years

In this paper, we report on a field experiment being carried out in a Typic Eutrorthox. The experiment was initiated in the 1997-98 agricultural season as a randomized block design with four treatments (0, 5, 10, and 20 t ha -1) of sewage sludge and five replicates. Compound soil samples were obtained from 20 subsamples collected at depths of 0-0.1 and 0.1-0.2 m. Cu, Fe, Mn, and Zn concentrations were extracted with DTPA pH 7.3; 0.1 mol L -1 HCl, Mehlich-I, Mehlich-III, and 0.01 mol L-1 CaCl 2. Metal concentrations were determined via atomic absorption spectrometry. Diagnostic leaves and the whole above-ground portion of plants were collected to determine Cu, Fe, Mn, and Zn concentrations extracted by nitric-perchloric digestion and later determined via atomic absorption spectrometry. Sewage sludge application caused increases in the concentrations of soil Cu, Fe, and Mn in samples taken from the 0-0.1 m depth evaluated by the extractants Mehlich-I, Mehlich-III, 0.01 mol L-1 HCl and DTPA pH 7.3. None of the extractants provided efficient estimates of changes in Mn concentrations. The acid extractants extracted more Cu, Fe, Mn, and Zn than the saline and chelating solutions. The highest concentrations of Cu, Fe, and Zn were obtained with Mehlich-III, while the highest concentrations of Mn were obtained with HCl. We did not observe a correlation between the extractants and the concentrations of elements in the diagnostic leaves nor in the tissues of the whole maize plant (Zea mays L.). © 2013 Springer Science+Business Media Dordrecht.

Perfil de cortisol, glicemia e de parâmetros sanguineos de girinos de rã-touro, Rana catesbeiana, em diferentes densidades e após exposição aérea

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Controle postural em adultos com síndrome de Down: acoplamento entre informação sensorial e oscilação corporal

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo da equivalência entre a lectina artin M obtida a partir da semente da jaca e a sua forma recombinante na afinidade por glicanas

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Determinação da taxa de ovulação e sua relação com diâmetro folicular e isoformas de mRNA para receptor de LH, em vacas da raça Nelore

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Variação do ciclo estral de novilhas Bos taurus indicus (Nelore) em diferentes estações do ano

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo químico e biológico do fungo endofítico C80 (Phaeosphaeriaceae) associado à alga marinha Bostrychia radicans

Pós-graduação em Química - IQ

Materiais compósitos orgânicos-inorgânicos a base de celulose bacteriana com peptídeos regulatórios de fatores de crescimento, OGP e OGP [10-14], para regeneração óssea

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Esteroides produzidos por Penicillium herquei, um fungo endofítico isolado dos frutos de Melia azedarach (Meliaceae)

ABSTRACT: Six compounds comprising the groups of steroids, the ergosterol, the ergosterol peroxide, the cerevisterol, the neociclocitrinols, the ergosta-4,6,8(14),22-tetraen-3-one, the 25-hydroxy-ergosta-4,6,8(14),22-tetraen-3-one, were isolated from Penicillium herquei fungus obtained from Melia azedarach. The structures were identified by spectral methods of RMN 1D and 2D and MS.

Níveis séricos de IgE total em crianças infectadas pelo vírus da imunodeficiência humana

Pós-graduação em Pediatria - FMB

Resposta luteal à PGF2α (Dinoprost Trometamina) durante as fases de luteogênese e manutenção do corpo lúteo em éguas

Pós-graduação em Medicina Veterinária - FMVZ

Structural, electronic and optical properties of Fe(III) complex with pyridine-2,6-dicarboxylic acid: A combined experimental and theoretical study

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)