Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus.

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Aortic Intima-Media Thickness and Mean Platelet Volume in Children With Type 1 Diabetes Mellitus

Background: Diabetes mellitus type 1 is the most common endocrine metabolic disorder occurring in childhood and adolescence due to the autoimmune destruction of pancreatic beta cells as a result of various environmental factors interacting with an underlying genetic predisposition. Diabetes is a risk factor for early onset atherosclerosis, and the high mortality rate seen in these patients is partially related to cardiovascular diseases. Objectives: This study was conducted to compare mean platelet volume as a marker of early atherosclerosis with aortic intima-media thickness in children with type 1 diabetes and to identify its correlation with known cardiovascular risk factors. Patients and Methods: The study included 27 patients between age range of 6 and 17 years that were diagnosed with type 1 diabetes and 30 healthy children of the same age range who did not have any chronic disease. In both groups, we used the color Doppler ultrasound to measure children’s aortic intima-media thickness and identify their mean platelet volumes. Results: There was no significant difference between the groups regarding gender distribution, age, High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL) cholesterol levels (P > 0.05). Also no significant difference could be documented between the patient and control groups regarding the aortic intima-media thickness and mean platelet volume (P > 0.05). However, there was a significant correlation between aortic intima-media thickness and mean platelet volume (r = 0.351; P < 0.05). Conclusions: In the present study, there was no evidence of early atherosclerosis in children with type 1 diabetes. However, mean platelet volume having a significant correlation with aortic intima-media thickness may be useful as an early marker of atherosclerosis.

Déterminants qui favorisent ou non l’autogestion du diabète de type 2 chez les personnes souffrant de cette maladie en Haïti

Cette étude exploratoire menée à Mirebalais (Haïti) vise à mieux comprendre les stratégies d’autogestion utilisées par les personnes diabétiques vivant dans cette commune. Nous nous sommes basés sur le modèle de la triade desease / illness / sickness décrit par Kleinman et al. (1978) et Young (1982) pour appréhender l’adaptation des personnes diabétiques dans leur environnement social et familial. Treize entrevues individuelles semi-structurées de diabétiques ont été réalisées. Les personnes qui arrivent à mieux vivre avec le diabète sont celles qui ont combiné les recommandations médicales, le savoir populaire et leur contexte de vie. Les résultats de cette étude peuvent être utilisés comme piste d’intervention dans des programmes entourant la prévention des complications de la maladie et l’amélioration des conditions de vie des diabétiques.

Envelhecimento e Diabetes Mellitus Tipo 2: estudo dos efeitos do exercício físico no comportamento postural e capacidade funcional de pacientes com Diabetes Mellitus Tipo 2

A Diabetes Mellitus é uma patologia fortemente associada ao processo de envelhecimento, afectando cada vez mais pessoas em todo o mundo. Uma das maiores complicações observadas nesta população prende-se com a diminuição do controlo postural e da capacidade funcional relacionada com a locomoção. O exercício físico tem sido apontado como uma das formas de prevenção e tratamento deste problema, no entanto existe ainda uma lacuna no conhecimento sobre o modo mais indicado de exercício. O presente pretende avaliar os efeitos de um programa de exercício físico aeróbio sobre o controlo postural e a capacidade funcional de pacientes portadores de Diabetes Mellitus Tipo 2. A amostra do estudo foi composta por 30 sujeitos de ambos os sexos, distribuídos por um grupo experimental (n=16) a quem foi aplicado o programa de exercício físico, e por um grupo de controlo (n=14), o qual não usufruiu de qualquer programa de exercício físico. O programa teve a duração de 12 semanas de treino, e uma frequência de 3 vezes por semana. Os participantes mantiveram-se em movimento constante durante as sessões tendo os exercícios realizados possuído uma forte componente dinâmica. Foi avaliado o controlo postural através de uma plataforma de forças e a capacidade funcional através de um conjunto de cinco testes funcionais. Os resultados obtidos revelam não terem existido diferenças estatisticamente significativas (p>0,05) na interacção entre grupos e momentos de avaliação nas variáveis analisadas, com excepção para a performance no Timed Get Up & Go Test, a qual melhorou significativamente (p<0,05) no grupo experimental. Estes dados sugerem que a especificidade tanto estática como dinâmica dos exercícios e a intensidade a que são realizados são factores fundamentais a ter em consideração no planeamento de programas de exercício físico, com vista à melhoria quer do controlo postural quer da capacidade funcional em portadores de Diabetes Mellius Tipo 2. ABSTRACT: Diabetes Mellitus is a disease associated with aging, affecting a growing number of people all over the world. One of the major concerns in this population relates to the decline of postural control and functional capacity. Exercise has been suggested as one way of preventing and treating this problem, however little is known about the most appropriate mode of exercise. This study evaluates the effect of an aerobic exercise program on postural control and functional capacity of patients with Type 2 Diabetes Mellitus. The sample consisted of 30 subjects, over an experimental group (n = 16) applied to an exercise program, and a control group (n = 14), that received no treatment. The program lasted 12 weeks, three times a week. Participants remained in constant motion during the sessions and the exercises performed had a strong dynamic component. Postural control was assessed using a force platform and functional capacity through a set of five functional tests. The results show that there were no statistically significant differences (p>O, O5) in group/moment interaction in the variables analyzed, except for the Timed Get Up & Go Test, which improved significantly (p <0,05) in the experimental group. These data suggest that both static and dynamic specificity and intensity of exercises are key factors in exercises programs planning, targeted to improve both postural control and functional capacity in patients with Type 2 Diabetes Mellius.