Portal de Busca Integrada

O SIBiUSP lançou em março de 2012 uma nova ferramenta de busca de conteúdos acadêmicos/científicos, o nome dado foi Portal de Busca Integrada. Esta ferramenta pertence à uma categoria de softwares intitulada de “Web Scale Discovery”, que permitem a integração de diversas e dispersas fontes de dados em uma única interface de busca e entrega de resultados. Dessa forma, apresentam-se aqui os processos de seleção e implantação desta solução.

Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction in growing animals: immunohistochemical analysis of the expression of TGF-β and VEGF

OBJECTIVE: During the neonatal and infancy periods, some chronic liver diseases may lead to progressive hepatic fibrosis, which is a condition that can ultimately result in the loss of organ function and severe portal hypertension necessitating hepatic transplantation. In a previous report, pharmacological interventions were demonstrated to modulate hepatic fibrosis induced by bile duct ligation in young rats. The administration of pentoxifylline or prednisolone, or the combination of both, resulted in reduced fibrogenesis in portal spaces. The objectives of the present study were to evaluate the expression of transforming growth factor β and vascular endothelial growth factor after bile duct ligation in young rats and to assess the effect of those same drugs on cytokine expression. METHODS: In this experimental study, 80 young rats (21 or 22 days old) were submitted either to laparotomy and common bile duct ligation or to sham surgery. The animals were allocated into four groups according to surgical procedure, and the following treatments were administered: (1) common bile duct ligation + distilled water, (2) sham surgery + distilled water, (3) common bile duct ligation + pentoxifylline, or (4) common bile duct ligation + prednisolone. After 30 days, a hepatic fragment was collected from each animal for immunohistochemical analysis using monoclonal antibodies against transforming growth factor β and vascular endothelial growth factor. Digital morphometric and statistical analyses were performed. RESULTS: The administration of pentoxifylline reduced the transforming growth factor β-marked area and the amount of transforming growth factor β expressed in liver tissue. This effect was not observed after the administration of prednisolone. There was a significant reduction in vascular endothelial growth factor expression after the administration of either drug compared with the non-treatment group. CONCLUSIONS: The administration of pentoxifylline to cholestatic young rats resulted in the diminished expression of transforming growth factor β and vascular endothelial growth factor in liver tissue. The administration of steroids resulted in the diminished expression of vascular endothelial growth factor only. These pathways may be involved in hepatic fibrogenesis in young rats submitted to bile duct ligation and exposed to pentoxifylline or prednisolone.

El Open Journal Systems en la Universidade de São Paulo: la experiencia de gestión del Portal de Revistas da USP

El objeto de este poster es presentar la experiencia de manejamiento de un portal de revistas científicas de acceso abierto, en una universidad pública y que integra los editores científicos, profesores y bibliotecarios. Iniciativas de esta naturaleza tienen importancia estratégica para la consolidación y el fortalecimiento del Movimiento de Acceso Abierto en los países en desarrollo, puesto que ofrecen la oportunidad de se vivir plenamente una cultura de acceso abierto en todas las etapas de certificación del conocimiento. La experiencia de la Universidade de São Paulo, se convierte en relevante, ya que promueve la integración de los diversos actores involucrados en la producción de revistas científicas. El Portal de Revistas da USP (http://www.revistas.usp.br), lanzado en 2008, es una iniciativa del Departamento Técnico do Sistema Integrado de Bibliotecas de USP que tiene el Programa de Apoio às Publicações Científicas Periódicas da USP. Esta iniciativa, basada en los principios del Movimiento de Acceso Abierto, tiene como objetivo promover la visibilidad y la accesibilidad de las revistas científicas publicadas oficialmente por la USP. Considerase que las revistas cumplen con un doble papel, como objeto y también vehículo de comunicación. Con esto las inversiones para calificación de las revistas incluyen recursos informáticos para garantizar la interoperabilidad entre distintos sistemas de información (bases de datos, catálogos, repositorios etc.), sistemas de gestión editorial en línea (para agilizar la tramitación de los manuscritos y la disminución de la publicación); la formación de los equipos (técnicos y bibliotecarios), atribuición de nomes DOI (digital object identifier), software de verificación de plágio. En 2012 se cambió el software de gestión del Portal para Open Journal Systems - OJS por lo cual se reunió por la primera vez, en um mismo dominio web las revistas científicas editadas en USP. De las más de 100 revistas publicadas en el Portal 29 están en DOAJ, 27 en SciELO Brasil, 20 en Scopus, 11 en JCR entre outros. En el Portal hay revistas con distintos perfiles, unas más institucionales y otras de calidad internacional. Algunas revistas más antíguas y consolidadas se utilizan de distintos sistemas de gestión de los manuscriptos y en el Portal es como un espejo para garantizar la presencia en la Universidad. Con tantas y tan distintas publicaciones el OJS se presenta como una promisora herramienta para la gestión del Portal de Revistas. El OJS surge como un sistema para la gestión individual de revistas científicos y con los avances de las tecnologías y principalmente del uso por la comunidad se conviertió en herramienta de gestión de Portal. Para una mejor gestión del Portal se presenta algunas recomendaciones, basadas en la experiencia, y que podrán mejorar el trabajo de gestión del conjunto de las revistas: en la pantalla de creación de revistas se deberá incluir todos los datos del registro oficial en ISSN, sin posibilidad de edición por los editores-gerentes; en el listado general de revistas se podría incluir una indicación de las revistas que están en línea y las que están aún en configuración; clara identificación de las revistas vigentes y no-vigentes, una vinculación mas clara de las revistas que cambiaran su título y que están vigentes; una tabla para selección de fuentes de indización; edición de contenidos ya publicados solamente por el administrador del sistema; gestión centralizada del DOI y de la preservación digital en LOCKSS y un painel con los datos estadísticos (total de revistas, ediciones, estatísticas Counter, autores etc). Además el fortalecimiento y creación de centros de desarrollo de OJS en las Universidades Latinoamericanas podría impulsionar el uso del sistema en su totalidad por los editores de la región.

Portal de Busca Integrada do SIBiUSP: metodologia de implantação

Relata o estudo, a instalação e implantação de ferramenta de descoberta e entrega do Portal de Busca Integrada, para o Sistema Integrado de Bibliotecas da Universidade de São Paulo (SIBiUSP). Esta nova interface denominada Portal de Busca Integrada possibilita uma nova experiência de pesquisa científica ao usuário final pela recuperação de literatura em diferentes fontes de informação.

Anomalous diffusion evidenced by particle tracking at high frame rates.

Diffusion is a common phenomenon in nature and generally is associated with a system trying to reach a local or a global equilibrium state, as a result of highly irregular individual particle motion. Therefore it is of fundamental importance in physics, chemistry and biology. Particle tracking in complex fluids can reveal important characteristics of its properties. In living cells, we coat the microbead with a peptide (RGD) that binds to integrin receptors at the plasma membrane, which connects to the CSK. This procedure is based on the hypothesis that the microsphere can move only if the structure where it is attached move as well. Then, the observed trajectory of microbeads is a probe of the cytoskeleton (CSK), which is governed by several factors, including thermal diffusion, pressure gradients, and molecular motors. The possibility of separating the trajectories into passive and active diffusion may give information about the viscoelasticity of the cell structure and molecular motors activity. And also we could analyze the motion via generalized Stokes-Einstein relation, avoiding the use of any active techniques. Usually a 12 to 16 Frames Per Second (FPS) system is used to track the microbeads in cell for about 5 minutes. Several factors make this FPS limitation: camera computer communication, light, computer speed for online analysis among others. Here we used a high quality camera and our own software, developed in C++ and Linux, to reach high FPS. Measurements were conducted with samples for 10£ and 20£ objectives. We performed sequentially images with different intervals, all with 2 ¹s exposure. The sequences of intervals are in milliseconds: 4 5 ms (maximum speed) 14, 25, 50 and 100 FPS. Our preliminary results highlight the difference between passive and active diffusion, since the passive diffusion is represented by a Gaussian in the distribution of displacements of the center of mass of individual beads between consecutive frames. However, the active process, or anomalous diffusion, shows as long tails in the distribution of displacements.

Portal de revistas da USP

O Portal de Revistas da USP apresenta-se como uma estratégia do Sistema Integrado de Bibliotecas, por meio de seu Programa de Apoio às Publicações Científicas Periódicas, para aumentar a visibilidade e acessibilidade das revistas científicas da Universidade de São Paulo. Para fazer parte deste Programa as revistas devem cumprir com critérios de qualidade, definidos por uma Comissão de Credenciamento, formada por professores e bibliotecários, e pautados em padrões internacionais. Atualmente 62 publicações estão credenciadas neste Programa.

Experimental model identification of open-frame underwater vehicles

Most of the works published on hydrodynamic parameter identification of open-frame underwater vehicles focus their attention almost exclusively on good coherence between simulated and measured responses, giving less importance to the determination of “actual values” for hydrodynamic parameters. To gain insight into hydrodynamic parameter experimental identification of open-frame underwater vehicles, an experimental identification procedure is proposed here to determine parameters of uncoupled and coupled models. The identification procedure includes: (i) a prior estimation of actual values of the forces/torques applied to the vehicle, (ii) identification of drag parameters from constant velocity tests and (iii) identification of inertia and coupling parameters from oscillatory tests; at this stage, the estimated values of drag parameter obtained in item (ii) are used. The procedure proposed here was used to identify the hydrodynamic parameters of LAURS—an unmanned underwater vehicle developed at the University of São Paulo. The thruster–thruster and thruster–hull interactions and the advance velocity of the vehicle are shown to have a strong impact on the efficiency of thrusters appended to open-frame underwater vehicles, especially for high advance velocities. Results of tests with excitation in 1-DOF and 3-DOF are reported and discussed, showing the feasibility of the developed procedure.

Engineering knowledge-based variance-reduction simulation and G-dominance for structural frame robust optimization

[EN] This paper proposes the incorporation of engineering knowledge through both (a) advanced state-of-the-art preference handling decision-making tools integrated in multiobjective evolutionary algorithms and (b) engineering knowledge-based variance reduction simulation as enhancing tools for the robust optimum design of structural frames taking uncertainties into consideration in the design variables.The simultaneous minimization of the constrained weight (adding structuralweight and average distribution of constraint violations) on the one hand and the standard deviation of the distribution of constraint violation on the other are handled with multiobjective optimization-based evolutionary computation in two different multiobjective algorithms. The optimum design values of the deterministic structural problem in question are proposed as a reference point (the aspiration level) in reference-point-based evolutionary multiobjective algorithms (here g-dominance is used). Results including

Portal de Accesibilidad y Comunicación

[ES]La educación inclusiva surge del convencimiento de que el derecho a la educación es un derecho universal que está en la base de una sociedad más justa. Uno de los ejes de este tipo de educación, entre otros, es la creación de entornos universales adaptados, e implica el acceso en condiciones de igualdad a una educación de calidad. En un campus inclusivo la herramienta on-line: PORTAL DE ACCESIBILIDAD Y COMUNICACIÓN (PAC) es una estrategia para la participación de la comunidad universitaria en donde cualquiera de sus miembros puede valorar la aplicación de las normas vigentes en materia de accesibilidad universal y proponer mejoras. La Universidad está llamada a ser un referente en la asunción de los derechos humanos, promoción del voluntariado y la no discriminación.

My Place. Luoghi, viaggi, identità nei romanzi di Janet Frame

Il lavoro si propone un’analisi dell’elemento spaziale e del movimento per ricostruire lo spazio della cultura neozelandese e lo spazio letterario di Janet Frame. La tesi si concentra in particolar modo sui romanzi con alcune incursioni nella fiction breve e nell’autobiografia. Si sviluppa in quattro capitoli nella forma di un itinerario attraverso la fiction dell'autrice preceduto da un capitolo che offre alcune coordinate teoriche e metodologiche sul concetto di spazio e la sua percezione. In particolare, una prospettiva fenomenologica e esistenziale alla questione appare congeniale all'analisi delle opere dell'autrice. Nell'ordine, quattro spazi concettuali si aprono a partire dai romanzi: linguaggio, etica, trascendenza e arte. Essi costituiscono i nuclei tematici e strutturali attorno ai quali si raccolgono i romanzi di Janet Frame e che consentono di analizzare i luoghi descritti nelle opere proponendo però una riflessione che va oltre la rappresentazione dello spazio per aprirsi sul retroterra culturale, intellettuale e filosofico dell'autrice. Emerge così l'originalità della sua posizione rispetto all'identità culturale del suo paese e alla relazioni che legano la Nuova Zelanda alla metropoli inglese e agli altri Paesi anglosassoni.

Effect of infill panels on the seismic response of a typical R.C. frame

Three structural typologies has been evaluated based on the nonlinear dynamic analysis (i.e. Newmark's methods for MDFs: average acceleration method with Modified Newton-Raphson iteration). Those structural typologies differ each other only for the infills presence and placement. In particular, with the term BARE FRAME: the model of the structure has two identical frames, arranged in parallel. This model constitutes the base for the generation of the other two typologies, through the addition of non-bearing walls. Whereas with the term INFILLED FRAME: the model is achieved by adding twelve infill panels, all placed in the same frame. Finally with the term PILOTIS: the model has been generated to represent structures where the first floor has no walls. Therefore the infills are positioned in only one frame in its three upper floors. All three models have been subjected to ten accelerograms using the software DRAIN 2000.

Frame-driven Extraction of Linked Data and Ontologies from Text

Ontology design and population -core aspects of semantic technologies- re- cently have become fields of great interest due to the increasing need of domain-specific knowledge bases that can boost the use of Semantic Web. For building such knowledge resources, the state of the art tools for ontology design require a lot of human work. Producing meaningful schemas and populating them with domain-specific data is in fact a very difficult and time-consuming task. Even more if the task consists in modelling knowledge at a web scale. The primary aim of this work is to investigate a novel and flexible method- ology for automatically learning ontology from textual data, lightening the human workload required for conceptualizing domain-specific knowledge and populating an extracted schema with real data, speeding up the whole ontology production process. Here computational linguistics plays a fundamental role, from automati- cally identifying facts from natural language and extracting frame of relations among recognized entities, to producing linked data with which extending existing knowledge bases or creating new ones. In the state of the art, automatic ontology learning systems are mainly based on plain-pipelined linguistics classifiers performing tasks such as Named Entity recognition, Entity resolution, Taxonomy and Relation extraction [11]. These approaches present some weaknesses, specially in capturing struc- tures through which the meaning of complex concepts is expressed [24]. Humans, in fact, tend to organize knowledge in well-defined patterns, which include participant entities and meaningful relations linking entities with each other. In literature, these structures have been called Semantic Frames by Fill- 6 Introduction more [20], or more recently as Knowledge Patterns [23]. Some NLP studies has recently shown the possibility of performing more accurate deep parsing with the ability of logically understanding the structure of discourse [7]. In this work, some of these technologies have been investigated and em- ployed to produce accurate ontology schemas. The long-term goal is to collect large amounts of semantically structured information from the web of crowds, through an automated process, in order to identify and investigate the cognitive patterns used by human to organize their knowledge.

Preliminary studies for the establishment of a tsunami early detection algorithm to be used in the frame of a Tsunami Warning System

This thesis presents and discusses TEDA, an algorithm for the automatic detection in real-time of tsunamis and large amplitude waves on sea level records. TEDA has been developed in the frame of the Tsunami Research Team of the University of Bologna for coastal tide gauges and it has been calibrated and tested for the tide gauge station of Adak Island, in Alaska. A preliminary study to apply TEDA to offshore buoys in the Pacific Ocean is also presented.

Portal hypertension: a comparison between portal-venous pressure measurement and ARFI measurement of liver and spleen stiffness

PURPOSE. Portal pressure is measured invasively as Hepatic Venous Pressure Gradient (HVPG) in the angiography room. Liver stiffness measured by Fibroscan was shown to correlate with HVPG values below 12 mmHg. This is not surprising, since in cirrhosis the increase of portal pressure is not directly linked with liver fibrosis and consequently to liver stiffness. We hypothesized that, given the spleen’s privileged location upstream to the whole portal system, splenic stiffness could provide relevant information about portal pressure. Aim of the study was to assess the relationship between liver and spleen stiffness measured by Virtual Touch™ (ARFI) and HVPG in cirrhotic patients. METHODS. 40 consecutive patients (30 males, mean age 62y, mean BMI=26, mean Child-Pugh A6, mean platelet count=92.000/mmc, 19 HCV+, 7 with ascites) underwent to ARFI stiffness measurement (10 valid measurements in right liver lobe both surface and centre, left lobe and 20 in the spleen) and HPVG, blindly to each other. Median ARFI values of 10 samplings on every liver area and of 20 samplings on spleen were calculated. RESULTS. Stiffness could be easily measured in all patients with ARFI, resulting a mean of 2,61±0,76, 2,5±0,62 and 2,55±0,66 m/sec in the liver areas and 3.3±0,5 m/s in the spleen. Median HPVG was 14 mmHg (range 5-27); 28 patients showed values ≥10 mmHg. A positive significant correlation was found between spleen stiffness and HPVG values (r=0.744, p<0.001). No significant correlation was found between all liver stiffness and HVPG (p>0,05). AUROC was calculated to test spleen stiffness ability in discriminating patients with HVPG ≥10. AUROC = 0.911 was obtained, with sensitivity of 69% and specificity of 91% at a cut-off of 3.26 m/s. CONCLUSION. Spleen stiffness measurement with ARFI correlates with HVPG in patients with cirrhosis, with a potential of identifying patients with clinically significant portal hypertension.