Heterozygote advantage and the maintenance of polymorphism for multilocus traits.

Explaining how polymorphism is maintained in the face of selection remains a puzzle since selection tends to erode genetic variation. Provided an infinitely large unsubdivided population and no frequency-dependance of selective values, heterozygote advantage is the text book explanation for the maintenance of polymorphism when selection acts at a diallelic locus. Here, we investigate whether this remains true when selection acts at multiple diallelic loci. We use five different definitions of heterozygote advantage that largely cover this concept for multiple loci. Using extensive numerical simulations, we found no clear associations between the presence of any of the five definitions of heterozygote advantage and the maintenance of polymorphism at all loci. The strength of the association decreases as the number of loci increases or as recombination decreases. We conclude that heterozygote advantage cannot be a general mechanism for the maintenance of genetic polymorphism at multiple loci. These findings suggest that a correlation between the number of heterozygote loci and fitness is not warranted on theoretical ground.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, October 2005

A-1 Monthly Public Assistance Statistical Report Family Investment Program, October 2005

A-1A Supplemental Security Income Program, October 2005

A-1A - Supplemental Security Income Program - October 2005

F-1 Food Assistance Program State Summary, October 2005

The Food Assistance Monthly Participation Report is a monthly summary of Food Assistance program participation, Statewide and for each Iowa county. Breakouts are reported for participants also in the FIP program, those only receiving Food Assistance, and those that are receiving economic assistance under other programs (primarily Medicaid). This report may also be known as the F-1 Report.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, November 2005

A-1 - Monthly Public Assistance Statistical Report Family Investment Program - November 2005

A-1A Supplemental Security Income Program, November 2005

A-A1 - Supplemental Security Income Program - November 2005

F-1 Food Assistance Program State Summary, November 2005

The Food Assistance Monthly Participation Report is a monthly summary of Food Assistance program participation, Statewide and for each Iowa county. Breakouts are reported for participants also in the FIP program, those only receiving Food Assistance, and those that are receiving economic assistance under other programs (primarily Medicaid). This report may also be known as the F-1 Report.

A Review of the Driver's License Issuance Program Administered by the Department of Transportation and the County Treasures, For the Fiscal Year Ended June 30, 2005

Other Audit Reports

A-1 Monthly Public Assistance Statistical Report-Family Investment Program, December 2005

A-1 December 2005 - Monthly Public Assistance Statistical Report - Family Investment Program

F-1 Food Assistance Program State Summary, December 2005

The Food Assistance Monthly Participation Report is a monthly summary of Food Assistance program participation, Statewide and for each Iowa county. Breakouts are reported for participants also in the FIP program, those only receiving Food Assistance, and those that are receiving economic assistance under other programs (primarily Medicaid). This report may also be known as the F-1 Report.

Case Management Program for the Frail Elderly, June 2005

The Case Management Program for the Frail Elderly (CMPFE) is a coordinated comprehensive system that strives to provide Iowa’s frail elderly clients with the opportunity to make their own choices regarding long-term care and to receive services in the home and community setting.

Iowa Division of Labor Contractor Registration Program Brochure, 2006

Frequently asked questions and answers regarding the Division of Labor Contractor Registration Law in Iowa.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, January 2006

Monthly Public Assistance Statistical Report Family Investment Program, January 2006

A-1A Supplemental Security Income Program, January 2006

Supplemental Security Income Program January 2006

A-1A Supplemental Security Income Program, December 2005

Supplemental Security Income Program December 2005