Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations within the major histocompatibility complex (MHC) region, 15 non-MHC loci reached genome-wide significance. Four of these loci are novel MS susceptibility loci. They map to the genes L3MBTL3, MAZ, ERG, and SHMT1. The lead variant at SHMT1 was replicated in an independent Sardinian cohort. Products of the genes L3MBTL3, MAZ, and ERG play important roles in immune cell regulation. SHMT1 encodes a serine hydroxymethyltransferase catalyzing the transfer of a carbon unit to the folate cycle. This reaction is required for regulation of methylation homeostasis, which is important for establishment and maintenance of epigenetic signatures. Our GWAS approach in a defined population with limited genetic substructure detected associations not found in larger, more heterogeneous cohorts, thus providing new clues regarding MS pathogenesis.

Informes presentados al Congreso nacional de educación primaria por las delegaciones de los estados, del Distrito federal y territorios en septiembre de 1910, al celebrarse el primer centenario de la independencia mexicana.

Prefixed to v. 1: Antecedentes, actas, debates y resoluciones del Congreso ... (140 p., 1 l.) This title is included as subtitle in the binder's lettering of v. 1.

La batalla de Santa Rosa : episodio dramático, en un acto y en verso /

No. 11, in vol. 10 with binder's title: Teatro Español : serie A.

Código de las leyes, decretos y acuerdos que sobre administración de justicia se ha dictado la Provincia de Mendoza.

Binder's title: Registro oficial, Mendoza.

Tabaré : drama lírico en tres actos (el tercero tiene dos cuadros) /

No. 9, in vol. 80 with binder's title: Teatro Español : serie A.

Bajo la selva : comedia dramática en tres actos /

No. 2, in vol. 141 with binder's title: Teatro Español : serie A.

La columna de fuego : drama en tres actos y cinco cuadros /

No. 2, in vol. 222 with binder's title: Teatro Español : serie A.

In occasione delle fauste nozze Giulio Zuccoli ed Aurora Rovetta bresciani : alcuni componimenti allusivi a Dante Alighieri.

Acquisition made accessible thanks to a 2015-2017 grant from the Council on Libraries and Information Resources.

Obseruationes in constitutiones dominij Mediolanensis /

Acquisition made accessible thanks to a 2015-2017 grant from the Council on Libraries and Information Resources.

Nel giorno XIX luglio MDCCCXLVI faustissimo e felicissimo, pel solenne ingresso di monsignore Bartolommeo de' conti Romilli alla sede vescovile di Cremona : omaggio di esultanza e d'amore.

Acquisition made accessible thanks to a 2015-2017 grant from the Council on Libraries and Information Resources.

Memorie istoriche intorno alla vita della beata Elisabetta Picenardi nobile vergine cremonese e terziaria dell'insigne Ordine de' servi di Maria /

Cavagna 10582: Bound with thirteen other Italian and Latin works, most from the 19th century; binder's title: "Opuscoli"; former shelf-mark Cavagna 10585.