Avaliação da prevalência do tipo de crescimento crânio facial nas diferentes más oclusões, de acordo com a classificação de angle

During the orthodontic correction planning in addition to dental-jaw correction, facial aesthetics is the orthodontist's and patient's major concern. To prevent facial aesthetics damage is really important to take into account the type of craniofacial growth: mesofacial (balanced), dolichofacial (vertical) or brachyfacial (horizontal). We evaluated 152 documentation files from the Department of Orthodontics of Dental University of Sao Jose dos Campos- UNESP in order to analyze what kind of growth occurs in most Class I malocclusions, Class II and Class III Angle of treated individuals from 6 to 12 years old. From the randomly collected samples, 15 of them belonged to Class I Angle malocclusions; 123 belonged to Angle Class II and 14 to Class III malocclusion. The results showed that in Class I, 66.67% were classified as dolicocephalic; in Class II, 64.23% were classified as dolicocephalic and in Class III, 50% were brachycephalic. We conclude that the dolichofacial was the type which ocurred the most, both in females and males and both in malocclusion Class I and Class II. The brachyfacial type most occurred in Class III malocclusion and the mesofacial type occurred in smaller numbers in the three malocclusions studied

Articulação temporomandibular: anatomia, dinâmica e disfunções temporomandibulares

This study gathered some of the most relevant researches already undertaken regarding the Temporomandibular Joint, presenting descriptions of its anatomy and dynamics, and relating them to the main aspects of joint dysfunctions. Literature recognizes that the Temporomandibular Joint, responsible for lower jaw movements, comprehends the skull base and the jaw bone. Its anatomy and dynamics are of great importance in order to understand the functions of Stomatognathic System as well as to study Temporomandibular Joint Dysfunction. The elements that compose this synovial joint and the bilateral characteristic confer eminent importance to the ATM before the skeleton head, the ability to perform broad movements and high complexity in its operation. It is accepted that the overload of one anatomical structure from the TMJ or other components of the Stomatognathic System leads to Temporomandibular Joint Dysfunctions. These disorders have different etiologies, ranging from malocclusion to emotional stress, and various forms of treatment, which are related in this study

Síntese e avaliação da capacidade de doação de óxido nítrico de novos compostos com atividade anti-agregante plaquetária úteis no tratamento de anemia falciforme

A anemia falciforme é uma doença genética caracterizada por uma anemia hemolítica crônica e fenômenos vaso-oclusivos, que levam a crises dolorosas e à lesão tecidual crônica e progressiva. Tem sido relatado que pacientes com anemia falciforme apresentam aumento dos níveis circulantes de citocinas, incluindo fator de necrose tumoral-α (TNF-α). O principal fármaco utilizado no tratamento dessa anemia é a hidroxiuréia (HU), fonte exógena de óxido nítrico (NO) e responsável pela inibição da agregação de plaquetas e aumento dos níveis de hemoglobina fetal (HbF). Trabalhos prévios têm demonstrado a importância da subunidade 1,2,5-oxadiazol-N-óxido como doadora de óxido nítrico. Nesse contexto, o presente trabalho tem como objetivo sintetizar um novo derivado híbrido do 1,2,5-oxadiol-N-óxido para a formação de um composto útil para o tratamento dos processos preventivos contra agregação plaquetária exacerbado em pacientes falciformes

Distribuição de tensões em bocais de vasos de pressão

This work is to analyze the behavior of context concentrated stresses generated around a nozzle connected to a pressure vessel. For this analysis we used the finite element method via a computer interface, the software ANSYS WORKBENCH. It was first necessary to study and intensive training of the software used, and also a study of the ASME Code, Section VIII, which is responsible for the standards used in pressure vessels. We analyzed three cases, which differ primarily in the variation of the diameter of the nozzle in order to analyze the variation of the stresses according to the variation of the diameters. The nozzle diameters were 35, 75 and 105 mm. After the model designed vessel, a pressure was applied on the innervessel of 0.5 MPa. For the smallest diameter, was found the lowest tensions concentrated. Varying between 1 and 223 MPa. Increasing the diameter of the nozzle resulted in increased tensions concentrated around the junction nozzle /vessel. The maximum stresses increased by 78% when the value was increased in diameter from 35 to 75 mm. Since the increase in diameter from 75 to 105 mm, the values of the tensions increased around 43%. These figures emphasize that stress concentrations increased with increasing the diameter of the nozzles, but not linearly

Achados clínicos, hemodinâmicos e hemogasométricos da infusão contínua de propofol associado ou não ao tramadol em ovelhas submetidas à videolaparoscopia

Pós-graduação em Cirurgia Veterinária - FCAV

Tratamento pós-colheita visando a longevidade floral de gladíolos (Gladiolus x hortulanus)

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Phenotypic expression of homozygous hemoglobin S in relation to β-globin haplotypes, glutathione S-transferase polymorphisms and detoxification enzymes

Sickle cell anemia (SCA) shows a pathophysiology that involves multiple changes in sickle cell erythrocytes, vaso-occlusive episodes, hemolysis, activation of inflammatory mediators, endothelial cell dysfunction, and oxidative stress. These events complicate treatment and culminate in the development of manifestations such as anemia, pain crises and multiorgan dysfunction. The aim of this study was to evaluate, in SCA patients, oxidative stress and antioxidant capacity markers, correlating them to treatment with hydroxyurea (HU), β-globin haplotypes and glutathione S-transferase polymorphisms (GSTT1, GSTM1 and GSTP1), in comparison to a control group (CG). The study groups were composed of 48 individuals without hemoglobinopathies (CG), SCA patients treated with HU [AF (+HU), N = 13] and untreated SCA patients [AF (-HU), N = 15], after informed consent. The groups were analyzed using cytological, electrophoretic, chromatographic and molecular methods and information from medical records. The GSTM1 and GSTT1 polymorphisms were determined by multiplex PCR, while the GSTP1 polymorphism by PCR-RFLP. Biochemical parameters were measured using spectrophotometric methods [TBARS, TEAC and catalase (CAT) and GST activities] and a chromatographic method [glutathione (GSH)]. The fetal Hb (Hb F) levels observed in the SCA (+HU) group (10.9%) confirmed the already well-described pharmacological effect of HU, but the SCA (-HU) group also had high Hb F levels (6.1%), which may have been influenced by genetic factors not targeted in this study. We found a higher frequency of the Bantu haplotype (48.2%), followed by the Benin (32.1%) and also Cameroon haplotypes, rare in our population, and 19.7% of atypical haplotypes. The presence of Bantu haplotype was related to higher lipid peroxidation levels in patients, but also, it conferred a differential response to HU treatment, raising Hb F levels in 52.6% (P = 0.03). The protective effect of Hb F was confirmed, because the increase in their levels resulted in a 41.3% decrease in lipid peroxidation levels (r = -0.74, P = 0.0156). The genotypic frequency of the GST polymorphisms observed was similar to that of other studies in the Brazilian population, and its association with biochemical markers revealed a significant difference only for the GSTP1 polymorphism, where patients with genotype V/V showed higher GSH and TEAC levels (P = 0.04 and P = 0.03, respectively) compared to patients with genotype I/I. The TBARS levels were about five to eight times higher in the SCA (+HU) and SCA (-HU) groups, respectively, compared to controls, and HU produced a 35.2% decrease in lipid peroxidation levels in the SCA (+HU) group (P < 0.0001). Moreover, the SCA (+HU) group showed higher TEAC levels when compared to CG (P = 0.002). We did not find any significant difference in GST activity between the groups studied (P = 0.76), but CAT activity was about 17 and 30% lower in SCA (+HU) and SCA (-HU) groups, respectively (P < 0.00001). Plasma GSH levels were ~2 times higher in SCA patients than in the control group (P = 0.0005) and showed a positive correlation with TBARS levels, confirming its antioxidant function. HU treatment contributed to higher CAT activity and TEAC levels and lower lipid peroxidation, and its pharmacological effect showed a “haplotype-dependent” response. These findings may contribute to elucidating the potential of HU in ameliorating oxidative stress in SCA subjects.

Farmacocinética da gentamicina asministrada pela via intravensa regional em equinos com a utilização de modelos de torniques

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Alterações bioquímicas e visuais na vida pós-colheita de antúrio (Anthurium andraeanum Linden ex Andre) em resposta a aplicação de citocina

Pós-graduação em Ciências Biológicas (Botânica) - IBB

Diagnóstico e tratamento precoce da Classe III: relato de um caso clínico

In malocclusion studies, may happen not only dental discrepancies but even skeletal discrepancies. In Class III malocclusion can be observed underdeveloped maxilla, mandible protraction or both of them, and, in most of the times associated with a narrow maxilla that causes anterior or posterior crossbites, in one side or in two sides. The aim of this case report is to evaluate the facial profile and occlusal effects of interceptive orthodontics therapy. The treatment with upper arch expansion and maxilla protraction was done in an early age to be effective in the circummaxillary sutural system and to make the orthopedic effect easier. The facial mask used is positioned on two facial points and allows an anterior maxillary replacement. Patients’ compliance is important to reach treatment success, this because using the mask still in this growth and development phase is essential to make the facial and occlusal effects happen. It is important to mention that patients with Angle Class III malocclusion need to be followed till the end of their growth.

Determinação do tempo de vida de restaurações totalmente cerâmicas (y-tzp/porcelana) com incidência da carga em diferentes regiões de contato

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Doses de potássio e umidades de solo para o crescimento de plantas de mogno-africano

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Diretrizes básicas para projetos de vasos de pressão segundo a ASME Trabalho

In this work it was made analysis of a simple pressure vessel, using the analytical development studied in Mechanics of Materials disciplines, and then using the standard required by ASME. Following the simulation was realized using Autodesk Mechanical Simulation software to calculate the principal stresses in a pressure vessel. The simulation was done in a single vessel without nozzles, compared with the analytic calculation. After that, the simulation of another fictitious pressure vessel was done by adding three nozzles to verify the influence of the nozzles in the principal stresses and compared with the analytical results. After the simulation, it was found that the principal are bigger in the pressure vessel with nozzles, but they decrease at a small distance from the nozzle becoming equal to the stresses in the vessel without nozzles. The analytical results calculated according to the ASME agree with simulated results

Estudo das alterações das propriedades mecânicas em aço A-516 grau 70 soldado e submetido a tratamento térmico de alívio de tensões

Pressure vessels are equipments that require a great care because of their high cost and human life risk in case of fail, and its fabrication methods are different for each manufacturer. Normally, pressure vessels and its parts are fabricated by welding, which may change local properties of metals. The head of a pressure vessel is a very important structural component and it is fabricated by welding and mechanical conformation. Because its excellent mechanical properties, de steel A-516 Grade 70 is often used in manufacturing of large pressure vessels that are subjected to high pressure and temperature, but was verified that its mechanical resistance is decreased when submitted to a tension relief heat treatment. By experience it was defined that before mechanical conformation of the head of a large pressure vessel, the steel should be submitted to a stress relief heat treatment in order to facilitate the mechanical conformation, but there is no quantitative analysis to prove this method and study its possible risks. In the present work the steel A-516 Grade 70 demonstrated a decrease of its mechanical resistance when submitted to a stress relief heat treatment, but keeping above the minimum limit defined in the literature. By other side its ductility was substantially increased, being possible to deduce that the stress relief heat treatment before mechanical conformation is a viable e recommended technique, but with reservations. With the data acquired during the fabrication e preparation of the specimen and the result of the tests, it was possible to elaborate a welding procedure that provides the same results obtained in this present work

Algumas reflexões sobre a condição da mulher brasileira da colônia às primeiras décadas do século XX

This article, about reflections on the condition of Brazilian women from the Colony to the first decades of the twentieth century, reveals the historical position of them and the attitudes and behaviors related to gender and sexuality. Subdued, it was treated as a sexual object, arousing all sorts of misogyny by men. Rebel, veiled or ostensibly, could serve their own desires. Throughout history, the Church and medical institutions which jointly accounted for, significantly, established the meaning and place of women. In Colony period, the woman is a ward from the Catholic ideology, but from the nineteenth century, after Independence, this power control arises to Medicine. The physician submits the religious discourse, naturalizing the status of women as one that breeds, namely the insertion of the medical issues of family scientifically legitimate colonial patriarchy. This is accentuated in the early twentieth century, when medicine consolidated setting standards and rules for marriage, to motherhood and family life. We note how the feminine universe was (and it is nowadays) ambivalent, with "one foot" in virtue and another in sin, with a tendency to contain and another to trespass. On the one hand we have the home and motherhood, validated in marriage, in which the woman is cared for and dependent on her husband. Reflecting on the motherhood of Virgin Mary, comes to the sacred dimension of the idealized woman saint by the Church. At the same time, however, feels the need for freedom, identity and independence, needing to give a voice to the desire to have their sexuality and all that it is due in full. The manifestation of the desire and the call for sexual satisfaction, and put in permanent conflict personal, psychological and social split between moral entrenched across generations and cultural transformations resulting from decades of the 20th Century.