Lichtheimia Infection in a Lymphoma Patient: Case Report and a Brief Review of the Available Diagnostic Tools

We describe the case of a patient with a T-lymphoblastic lymphoma whose disseminated mucormycosis was diagnosed with delay, and we address the diagnostic and therapeutic decision-making process and review the diagnostic workup of patients with potential IFD. The diagnosis was delayed despite a suggestive radiological presentation of the patient's pulmonary lesion. The uncommon risk profile (T-lymphoblastic lymphoma, short neutropenic phases) wrongly led to a low level of suspicion. The diagnosis was also hampered by the lack of indirect markers for infections caused by Mucorales, the low sensitivity of both fungal culture and panfungal PCR, and the limited availability of species-specific PCR. A high level of suspicion of IFD is needed, and aggressive diagnostic procedures should be promptly initiated even in apparently low-risk patients with uncommon presentations. The extent of the analytical workup should be decided on a case-by-case base. Diagnostic tests such as the galactomannan and β-D-glucan test and/or PCR on biological material followed by sequencing should be chosen according to their availability and after evaluation of their specificity and sensitivity. In high-risk patients, preemptive therapy with a broad-spectrum mould-active antifungal agent should be started before definitive diagnostic findings become available.

Towards moldable development tools

Developers commonly ask detailed and domain-specific questions about the software systems they are developing and maintaining. Integrated development environments (IDEs) form an essential category of tools for developing software that should support software engineering decision making. Unfortunately, rigid and generic IDEs that focus on low-level programming tasks, that promote code rather than data, and that suppress customization, offer limited support for informed decision making during software development. We propose to improve decision making within IDEs by moving from generic to context-aware IDEs through moldable tools. In this paper, we promote the idea of moldable tools, illustrate it with concrete examples, and discuss future research directions.

Tools for compliance for the medical device and in vitrol diagnostic product industries.

Mode of access: Internet.

Final report -- a survey of software tools usage /

S/N 003-003-02378-7

Hand and power tools : a compilation /

At head of title: Technology utilization.

Machinery, equipment, and tools : a compilation.

Cover title.

Tools for embedded computing systems software.

"Preprint for a workshop sponsored by NASA Langley Research Center, Hampton, Virginia, and the American Institute of Aeronautics and Astronautics, New York, and held in Hampton, Virginia, November 7-8, 1978."

Identifying and implementing corridor safety improvements: a highway safety improvement process and safety analysis tools for Arizona.

Arizona Department of Transportation, Phoenix

Support for the analytical tools for automotive fuel economy activities. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Prevention plus II : tools for creating and sustaining drug-free communities.

Mode of access: Internet.

Transportation infrastructure: better tools needed for making decisions on using ISTEA funds flexibly.

Mode of access: Internet.

The new metal worker pattern book; a complete course of instruction in the modern methods of developing and cutting the patterns for sheet metal work, giving the principles underlying practically every problem that is likely to come up in practice and explaining the selection and use of drawing tools and linear and geometrical drawing so clearly that one, who has had no previous knowledge of arithmetic or drawing, may understand these essentials and apply them in using the 253 problems in the development of patterns by the parallel line, conical or flaring, and triangulation systems.

Mode of access: Internet.

Computer program for incentives (a description of a computer program that generates incentive contracting visibility tools), May 1970.

Mode of access: Internet.

The mechanic's companion : or, The elements and practice of carpentry, joinery, bricklaying, masonry, slating, plastering, painting, smithing, and turning, comprehending the latest improvements and containing a full description of the tools belonging to each branch of business, with copious directions for their use, an explanation of the terms used in each art and an introduction to practical geometry /

Mode of access: Internet.

Translator writing tools (TWT); preliminary report.

Bibliography: p. 31.