Lack of DNA damage induced by fluoride on mouse lymphoma and human fibroblast cells by single cell gel (comet) assay

Fluoride has widely been used in Dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury on genetic apparatus. Genotoxicity tests constitute an important part of cancer research for risk assessment of potential carcinogens. In this study, the potential DNA damage associated with exposure to fluoride was assessed by the single cell gel (comet) assay in vitro. Mouse lymphoma and human fibroblast cells were exposed to sodium fluoride (NaF) at final concentration ranging from 7 to 100 μg/mL for 3 h at 37μC. The results pointed out that NaF in all tested concentrations did not contribute to DNA damage as depicted by the mean tail moment and tail intensity for both cellular types assessed. These findings are clinically important because they represent a valuable contribution for evaluation of the potential health risk associated with exposure to agents usually used in dental practice.

Comparison of resin push-out strength to root dentin of bovine- and human-teeth

Aim : To compare the push-out strength of bovine- and human-root dentin and, thus, evaluate the suitability of bovine-root dentin to substitute human-root dentin for bond strength testing. Materials and Methods : Ten single-rooted human-teeth and ten bovine incisors were prepared using a #3 bur of a fiber post system (12 mm long). The posts were duplicated with resin cement (Duolink). The root canals were treated with All Bond 2 adhesive system and the resin posts were cemented using Duolink. The specimens were cut perpendicular to their long axis, yielding disc-specimens with 1.5 mm thickness, which were submitted to a push-out test (1 mm/min). Ten bond strength values per group (n = 10) were used for statistical analysis (Student t test, a =.05). Results : Statistically significant differences were found for the bond strength values between bovine- (4.1 1.3 MPa) and human-root dentin (8.6 5.7 MPa) (P =.0001). Conclusion : The push-out strengths of bovine- and human-root dentin were statistically different.

Science and technology policies in open economies: the case of Latin America and the Caribbean

Includes bibliography

The challenge of gender equity and human rights on the threshold of the twenty-first century

Includes bibliography

Science and technology for sustainable development: a Latin American perspective

This publication, compiled by Gilberto C. Gallopín, Regional Adviser in Environmental Policy for Latin America and the Caribbean, contains the results of the deliberations of the Latin American and Caribbean Regional Workshop on Science and Technology for Sustainable Development. The purpose of the Workshop was to discuss the practical, theoretical and organizational challenges that the quest for sustainable development poses to science and technology (S&T). The increase in complexity and connectivity characteristic of our times results in that the components of the problems are now much less separable than before, and emphasizes the need to approach the problems of development and the environment not only as complex issues in themselves, but also as inseparable and mutually determined. This represents an exceptional challenge to science and technology, particularly to the analytical approaches compartmentalized into disciplines, which represents the bulk of activities and priorities of current S&T systems in both north and south. The Workshop attempted to articulate a Latin American and Caribbean vision towards the search of more effective ways of generating and applying Science and Technology to the problems and opportunities of the region.

Mobility and human rights

Includes bibliography

Migration and human rights

Includes bibliography

Trafficking in women: connections and disconnections between gender, migration and human rights

Includes bibliography

A virtual contradiction between international migration and human rights

Includes bibliography

Sustainable development: epistemological challenges to science and technology. Report of the workshop Sustainable Development: Epistemological Challenges to Science and Technology""

Includes bibliography

A virtual contradiction between international migration and human rights

Includes bibliography

Science and technology policy and the National Innovation System in Argentina

Includes bibliography

Economic growth and human development in Latin America

Includes bibliography