999 resultados para Scale [ca. 1:7,000,000]None


Relevância:

100.00% 100.00%

Publicador:

Resumo:

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Relevância:

100.00% 100.00%

Publicador:

Resumo:

The acute direct action of angiotensin-(1-7) [ANG-(1-7)] on bicarbonate reabsorption (JHCO(3)(-)) was evaluated by stationary microperfusions on in vivo middle proximal tubules in rats using H ion-sensitive microelectrodes. The control JHCO(3)(-) is 2.82 ± 0.078 nmol·cm(-2)·s(-1) (50). ANG-(1-7) (10(-12) or 10(-9) M) in luminally perfused tubules decreases JHCO(3)(-) (36 or 60%, respectively), but ANG-(1-7) (10(-6) M) increases it (80%). A779 increases JHCO(3)(-) (30%) and prevents both the inhibitory and the stimulatory effects of ANG-(1-7) on it. S3226 decreases JHCO(3)(-) (45%) and changes the stimulatory effect of ANG-(1-7) to an inhibitory effect (30%) but does not affect the inhibitory effect of ANG-(1-7). Our results indicate that in the basal condition endogenous ANG-(1-7) inhibits JHCO(3)(-) and that the biphasic dose-dependent effect of ANG-(1-7) on JHCO(3)(-) is mediated by the Mas receptors via the Na(+)/H(+) exchanger 3 (NHE3). The control value of intracellular Ca(2+) concentration ([Ca(2+)](i)), as monitored using fura-2 AM, is 101 ± 2 nM (6), and ANG-(1-7) (10(-12), 10(-9), or 10(-6)M) transiently (3 min) increases it (by 151, 102, or 52%, respectively). A779 increases the [Ca(2+)](i) (25%) but impairs the stimulatory effect of all doses of ANG-(1-7) on it. The use of BAPTA or thapsigargin suggests a correlation between the ANG-(1-7) dose-dependent effects on [Ca(2+)](i) and JHCO(3)(-). Therefore, the interaction of the opposing dose-dependent effects of ANG II and ANG-(1-7) on [Ca(2+)](i) and JHCO(3)(-) may represent an physiological regulatory mechanism of extracellular volume and/or pH changes. However, whether [Ca(2+)](i) modification is an important direct mechanism for NHE3 activation by these peptides or is a side effect of other signaling pathways will require additional studies.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Palaeoecological investigations in the larch forest-tundra ecotone in northern Siberia have the potential to reveal Holocene environmental variations, which likely have consequences for global climate change because of the strong high-latitude feedback mechanisms. A sediment core, collected from a small lake (radius ~100 m), was used to reconstruct the development of the lake and its catchment as well as vegetation and summer temperatures over the last 7100 calibrated years. A multi-proxy approach was taken including pollen and sedimentological analyses. Our data indicate a gradual replacement of open larch forests by tundra with scattered single trees as found today in the vicinity of the lake. An overall trend of cooling summer temperature from a ~2 °C warmer-than-present mid-Holocene summer temperatures until the establishment of modern conditions around 3000 years ago is reconstructed based on a regional pollen-climate transfer function. The inference of regional vegetation changes was compared to local changes in the lake's catchment. An initial small water depression occurred from 7100 to 6500 cal years BP. Afterwards, a small lake formed and deepened, probably due to thermokarst processes. Although the general trends of local and regional environmental change match, the lake catchment changes show higher variability. Furthermore, changes in the lake catchment slightly precede those in the regional vegetation. Both proxies highlight that marked environmental changes occurred in the Siberian forest-tundra ecotone over the course of the Holocene.

Relevância:

100.00% 100.00%

Publicador:

Relevância:

100.00% 100.00%

Publicador:

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Los objetivos propios del proyecto propuesto se centran en describir las fases necesarias del proceso de producción de la Base Cartográfica Nacional a escala 1:200.000, cuyo producto final es plasmado en un mapa cartográfico concreto; Mapa Provincial con la misma escala. Todas las tareas esenciales para su elaboración se realizan de acuerdo a la finalidad principal que persigue la creación de un mapa, que es la representación clara y concisa de los elementos geográficos que definen una extensión de territorio. Se pone de manifiesto las normas y reglas específicas que son necesarias para dicha producción, atendiendo las condiciones que presenta el modelo de la base de datos concreta, compuesto por la información válida con carácter oficial, ya que debe estar registrada por las instituciones del Estado, de forma que el conjunto de información sea la más adecuada a la realidad objetiva. Se siguen aquellas pautas referentes a la captura de los datos que componen dicho modelo, teniendo en cuenta la escala cartográfica a la que se representan y ciertas condiciones geométricas. Así como aquellas normas que guían los procesos de controles de calidad y generalización de la información geográfica. También, se establecen de forma fija la serie de estilos de representación de las geometrías componen el mapa, y la simbología utilizada para identificar las entidades definidas mediante elementos puntuales. Las reglas principales descritas son las concernientes a la edición de los conflictos cartográficos producidos a la hora de representar los datos reales. La BCN200 se crea con la finalidad principal de recopilar toda la información cartográfica que define el aspecto y el conjunto de detalles, tanto geográficos y naturales, como aquellos aportados por las construcciones realizadas por el ser humano, de la superficie terrestre que abarca el territorio nacional, con la finalidad de facilitar el desarrollo de tareas semiautomáticas para obtener una producción de diversas elaboraciones cartográficas, digitales o impresas.

Relevância:

100.00% 100.00%

Publicador: