A treatise on blood pressure in ocular work, with special reference to factors of interest to refractionists,

Frontispiece accompanied by guard sheet with descriptive letterpress.

A sermon preached in the Second Presbyterian Church, Albany, Sabbath evening, May 11, 1834 : and repeated by special request, on the ensuing Tuesday evening in the Second Reformed Dutch Church, in behalf of the Polish exiles lately arrived in this country /

"Whatever profits may arise from the sale of this discourse, will be applied for the relief of the Polish exiles."

Grammar simplified, or, An ocular analysis of the English language [microform].

Master microform held by: Readex.

Grammar simplified; or, An ocular analysis of the English language.

Mode of access: Internet.

Grammar simplified, or An ocular analysis of the English language.

Mode of access: Internet.

Intemperance among literary men. An address, delivered before the Portland Young Men's Total Abstinence Society, on Sunday evening, July 31, in the Park Street Church and repeated, by request, on Sunday evening, Aug. 7, in the First Parish Church.

Mode of access: Internet.

Liberty and law : a lecture delivered before the Young Men's Association in Geneva, New-York, November 8, 1837, introductory to their course of lectures for the season, and repeated before the Young Men's Association, at Waterloo, N.Y., February 2, 1838 /

Mode of access: Internet.

Physiologic optics : dioptrics of the eye, functions of the retina ocular movements and binocular vision /

Includes bibliographies and indexes.

The theory of ocular defects and of spectacles /

Mode of access: Internet.

A hand-book of ocular therapeutics,

Spine title: Ocular therapeutics.

Repeated manual release in a young plantation : effect on Douglas-fir seedlings, hardwoods, shrubs, forbs, and grasses /

Includes bibliographical references (p. 11).

Glutamate transporter localization does not correspond to the temporary functional recovery and late degeneration after acute ocular ischemia in rats

Purpose: To determine whether the localization of retinal glutamate transporters is affected by retinal ischaemia and whether their ability to transport glutamate decreases with the progression of ischemic retinal and optic nerve degeneration. Methods: Retinal ischemia was induced in rats by acutely increasing the intraocular pressure (IOP, 110 mmHg/60 min). Reperfusion was permitted for periods up to 60 days post-ischemia. Functional evaluation was performed by monitoring the pupil light reflexes (PLRs) and electroretinograms (flash, flicker ERG and oscillatory potentials). Glutamate transporter localization and D-aspartate (glutamate analogue) uptake were assessed by immunohistochemistry. Results: Intense immunoreactivity for the retinal glutamate transporters (GLAST, GLT1, EAAC1 and EAAT5) was observed at all time points after the insult, despite severe retinal degeneration. D-aspartate was also normally accumulated in the ischemic retinas. Ten days post-operatively the PLR ratio (ratio = indirect/direct PLR = 34 +/- 7(.)5%) was significantly less than the pre-operative value (pre-op = 76(.)7 +/- 2 (.)6%, p < 0(.)05). However, 25 and 35 days post-operatively PLR ratios did not differ significantly from pre-operative values (44(.)4 +/- 6(.)9 and 53(.)8 +/- 9(.)6%, p > 0(.)05). Forty-five and 60 days post-operatively the PLR ratio declined again and was significantly lower than the pre-operative value (33(.)8 + 8(.)7 and 26(.)2 + 8(.)9%, p < 0(.)05). Statistical analysis revealed that all tested ERG components had significantly higher values at 32, but not at 42 and 58 days post-operatively when compared to the first time point recorded post-operatively (10 days). Conclusions: While retinal glutamate transport is compromised during an acute ischemic insult, consequent retinal recovery and degeneration are not due to a change in the excitatory amino acid transporter localization or D-aspartate (glutamate analogue) uptake. Rat retina and optic nerve are capable of spontaneous, but temporary, functional recovery after an acute ischemic insult. (C) 2004 Elsevier Ltd. All rights reserved.

Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys

Vascular endothelial growth factor (VEGF) is one of the major mediators of retinal ischemia-associated neovascularization. We have shown here that adeno-associated virus (AAV)-mediated expression of sFIt-1, a soluble form of the Flt-1 VEGF receptor, was maintained for up to 8 and 17 months postinjection in mice and in monkeys, respectively. The expression of sFIt-1 was associated with the long-term (8 months) regression of neovascular vessels in 85% of trVEGF029 eyes. In addition, it resulted in the maintenance of retinal morphology, as the majority of the treated trVEGF029 eyes (75%) retained high numbers of photoreceptors, and in retinal function as measured by electroretinography. AAV-mediated expression of sFIt-1 prevented the development of laser photocoagulation-incluced choroidal neovascularization in all treated monkey eyes. There were no clinically or histologically detectable signs of toxicity present in either animal model following AAV.sFlt injection. These results suggest that AAV-mediated secretion gene therapy could be considered for treatment of retinal and choroidal neovascularizations.