995 resultados para Hobson, Victor
Resumo:
This flyer promotes the event "The Cuban Poetry of Alfonso Camín, Father of Afro-Cuban Poetry : Lecture by Victor Puertodan" cosponsored by the FlU Initiative for Spanish and Mediterranean Studies.
Resumo:
General note: Title and date provided by Bettye Lane.
Resumo:
The over-riding perceptions of Victor Hugo’s attitudes towards women are intensely coloured by his deep-seated Romanticism and his well-testified, stifling and over-bearing treatment of women in his personal life. As such, Hugo’s contribution to the feminist struggle of his time has been woefully overlooked in the larger scheme of his social and political activism. Through a close examination of his largely unstudied public discourse on women’s rights, this thesis situates Hugo’s feminist views firmly in the context of Enlightenment feminism and 19th century feminism, while also drawing heavily on the illuminating principles of Enlightenment feminism. In particular, this thesis examines Hugo’s support for several of the most determining issues of 19th century French feminism, including women’s right to education, equal citizenship, universal suffrage rights, and the issue of regulated prostitution. Further, by examining the way in which Hugo’s views on women’s maternal role extended far beyond the limited vision of domesticity bolstered by the ideology of ‘republican motherhood’, this thesis engages in a re-appraisal of Hugo’s literary representation of maternity which identifies the maternal as a universal quality of devotion and self-sacrifice to which all humankind must aspire for the creation of a just, egalitarian, and democratic society. Though at times inevitably constrained by his Romanticism, this thesis demonstrates the extent to which Hugo’s feminism is grounded in his wider vision of social emancipation and is underpinned by a profound empathy, compassion, and moral conscience – qualities which are just as fundamental today, as they were for Hugo when participating in the fitful, though decisive, feminist struggle in 19th century France.
Resumo:
This material is based upon work supported by the National Science Foundation through the Florida Coastal Everglades Long-Term Ecological Research program under Cooperative Agreements #DBI-0620409 and #DEB-9910514. This image is made available for non-commercial or educational use only.
Resumo:
Publicam-se neste capítulo a data de radiocarbono obtida para o Menhir do Patalou e discutem-se as outras datas disponíveis para os menhires portugueses com especial destaque para a data do menhir da Meada.
Resumo:
O objetivo deste artigo é apresentar uma síntese histórica dos estudos de propriedades estáticas de gases reais feitas pelo experimentalista francês Regnault e estabelecer a sua relação com a recepção francesa da teoria cinética dos gases durante a segunda metade do século XIX, notando a sua relevância epistemológica. Com este caso histórico ilustra-se a complexa relação entre a teoria e a experimentação.
Resumo:
Intervir numa preexistência é como que escutar o eco das vivências que aí ocorreram. Nesses lugares, as paredes registam as vivências do tempo, a que não podemos ficar indiferentes, em face de terem sido espaços de felicidade ou de emoções negativas. Lugares que acolheram, outrora, determinadas vivências configuram aquilo a que denominamos de "a espessura do tempo na arquitectura". Intervimos assim numa procura de interligação temporal onde, o passado resgatado às suas memórias, se transmuta em elo de ligação entre passado, presente e futuro. O que realmente procuramos é um elo ético para com a continuidade patrimonial, onde o homem é a medida e a razão de ser das intervenções. Consideramos igualmente fundamental a permanente investigação que realizamos no âmbito das arquitecturas vernacular, tradicional e erudita nomeadamente os seus materiais, tecnologias, configurações espácio-funcionais, composições artísticas, em conjunto com as dinâmicas sociais, permitindo em cada projecto que realizamos identificar a identidade cultural em presença. As intervenções que apresentamos refletem esse percurso num contexto hereditário, de passagem de testemunho, a enobrecer com as propostas de projecto, onde sobressai a função social do arquitecto.
Resumo:
ARQUITECTURA DISPUESTA: PREPOSICIONES COTIDIANAS propone mostrar aquellas prácticas arquitectónicas que desarrollan una relación operativa y sensible con el contexto, que muestran una actitud pragmática y experimental en el proceso, que condensan y manifiestan una propuesta espacial, hacia tecnologías, materialidades, subjetividades contemporáneas y cotidianas. Una forma sencilla de expresar cómo la arquitectura se relaciona y proyecta el espacio cotidiano es a través de las preposiciones. A, ante, bajo, con, contra, de, desde, durante, en, entre, hacia, hasta, mediante, para, por, pro, según, sin, sobre, tras, vía, describen la relación los espacios cotidianos que este programa propone explicitar, debatir y desarrollar para mostrar los vínculos entre práctica arquitectónica, contexto social y cultural en que se produce. La atención por la experiencia inmediata del espacio y su materialidad, la preocupación por incorporar a los agentes productores, los participantes e implicados en la obra, y la puesta en valor del ‘proceso’ que se desarrolla en los proyectos mostrados, resume una ‘actitud’ que deviene en obra construida. Son propuestas espaciales y materiales que median entre el espíritu de un tiempo presente (Zeitgeist) y su ingenio (Erfindergeist).
Resumo:
36
Resumo:
This study proposes to investigate quercetin antitumor efficacy in vitro and in vivo, using the P39 cell line as a model. The experimental design comprised leukemic cells or xenografts of P39 cells, treated in vitro or in vivo, respectively, with quercetin; apoptosis, cell-cycle and autophagy activation were then evaluated. Quercetin caused pronounced apoptosis in P39 leukemia cells, followed by Bcl-2, Bcl-xL, Mcl-1 downregulation, Bax upregulation, and mitochondrial translocation, triggering cytochrome c release and caspases activation. Quercetin also induced the expression of FasL protein. Furthermore, our results demonstrated an antioxidant activity of quercetin. Quercetin treatment resulted in an increased cell arrest in G1 phase of the cell cycle, with pronounced decrease in CDK2, CDK6, cyclin D, cyclin E, and cyclin A proteins, decreased Rb phosphorylation and increased p21 and p27 expression. Quercetin induced autophagosome formation in the P39 cell line. Autophagy inhibition induced by quercetin with chloroquine triggered apoptosis but did not alter quercetin modulation in the G1 phase. P39 cell treatment with a combination of quercetin and selective inhibitors of ERK1/2 and/or JNK (PD184352 or SP600125, respectively), significantly decreased cells in G1 phase, this treatment, however, did not change the apoptotic cell number. Furthermore, in vivo administration of quercetin significantly reduced tumor volume in P39 xenografts and confirmed in vitro results regarding apoptosis, autophagy, and cell-cycle arrest. The antitumor activity of quercetin both in vitro and in vivo revealed in this study, point to quercetin as an attractive antitumor agent for hematologic malignancies.
Resumo:
In acquired immunodeficiency syndrome (AIDS) studies it is quite common to observe viral load measurements collected irregularly over time. Moreover, these measurements can be subjected to some upper and/or lower detection limits depending on the quantification assays. A complication arises when these continuous repeated measures have a heavy-tailed behavior. For such data structures, we propose a robust structure for a censored linear model based on the multivariate Student's t-distribution. To compensate for the autocorrelation existing among irregularly observed measures, a damped exponential correlation structure is employed. An efficient expectation maximization type algorithm is developed for computing the maximum likelihood estimates, obtaining as a by-product the standard errors of the fixed effects and the log-likelihood function. The proposed algorithm uses closed-form expressions at the E-step that rely on formulas for the mean and variance of a truncated multivariate Student's t-distribution. The methodology is illustrated through an application to an Human Immunodeficiency Virus-AIDS (HIV-AIDS) study and several simulation studies.
Resumo:
A Bacillus cereus strain, FT9, isolated from a hot spring in the midwest region of Brazil, had its entire genome sequenced.
Resumo:
Witches' broom disease (WBD), caused by the hemibiotrophic fungus Moniliophthora perniciosa, is one of the most devastating diseases of Theobroma cacao, the chocolate tree. In contrast to other hemibiotrophic interactions, the WBD biotrophic stage lasts for months and is responsible for the most distinctive symptoms of the disease, which comprise drastic morphological changes in the infected shoots. Here, we used the dual RNA-seq approach to simultaneously assess the transcriptomes of cacao and M. perniciosa during their peculiar biotrophic interaction. Infection with M. perniciosa triggers massive metabolic reprogramming in the diseased tissues. Although apparently vigorous, the infected shoots are energetically expensive structures characterized by the induction of ineffective defense responses and by a clear carbon deprivation signature. Remarkably, the infection culminates in the establishment of a senescence process in the host, which signals the end of the WBD biotrophic stage. We analyzed the pathogen's transcriptome in unprecedented detail and thereby characterized the fungal nutritional and infection strategies during WBD and identified putative virulence effectors. Interestingly, M. perniciosa biotrophic mycelia develop as long-term parasites that orchestrate changes in plant metabolism to increase the availability of soluble nutrients before plant death. Collectively, our results provide unique insight into an intriguing tropical disease and advance our understanding of the development of (hemi)biotrophic plant-pathogen interactions.