A descriptive catalogue (with remarks and anecdotes never before published in English) of some pictures, of the different schools, purchased for His Majesty the late King of Poland, which will be exhibited early in 1802, at the Great Room, No. 3, in Berners-Street, the third door on the right, from Oxford-Street /

Mode of access: Internet.

Biographical register of the officers and graduates of the U.S. Military Academy at West Point, N.Y. : from its establishment, in 1802, to 1890, with the early history of the United States Military Academy /

Continued by Register of graduates and former cadets of the United States Military Academy.

Journal of the Legislative Assembly of the Province of Prince Edward Island.

Mode of access: Internet.

A merchant prince : life of Hon. Senator John Macdonald /

Mode of access: Internet.

The life of Flora Macdonald, and her adventures with Prince Charles. With a life of the author, and an appendix giving the descendents of the famous heroine,

Mode of access: Internet.

Acadian geology. The geological structure, organic remains, and mineral resources of Nova Scotia, New Brunswick, and Prince Edward Island.

"Geological bibliography of the Acadian provinces," p. 9-13.

Judicial opinions delivered in the Mayor's Court of the City of New-York, in the year 1802.

"Rules and orders": p. [83]-105.

A narrative of the most remarkable particulars in the life of James Albert Ukawsaw Gronniosaw, an African prince, as related by himself.

Compare with, Library Company of Philadelphia. Afro-Americana, 1553-1906 (2nd edition), supplement 980.

Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis

Aims To investigate the concentration-effect relationship and pharmacokinetics of leflunomide in patients with rheumatoid arthritis (RA). Methods Data were collected from 23 RA patients on leflunomide therapy (as sole disease modifying antirheumatic drug (DMARD)) for at least 3 months. Main measures were A77 1726 (active metabolite of leflunomide) plasma concentrations and disease activity measures including pain, duration/intensity of morning stiffness, and SF-36 survey. A population estimate was sought for apparent clearance (CL/F ) and volume of distribution was fixed (0.155 l kg(-1)). Factors screened for influence on CL/F were weight, age, gender and estimated creatinine clearance. Results Significantly higher A77 1726 concentrations were seen in patients with less swollen joints and with higher SF-36 mental summary scores than in those with measures indicating more active disease (P < 0.05); concentration-effect trends were seen with five other disease activity measures. Statistical analysis of all disease activity measures showed that mean A77 1726 concentrations in groups with greater control of disease activity were significantly higher than those in whom the measures indicated less desirable control (P < 0.05). There was large between subject variability in the dose-concentration relationship. A steady-state infusion model best described the pharmacokinetic data. Inclusion of age as a covariate decreased interindividual variability (P < 0.01), but this would not be clinically important in terms of dosage changes. Final parameter estimate (% CV interindividual variability) for CL/F was 0.0184 l h(-1) (50%) (95% CI 0.0146, 0.0222). Residual (unexplained) variability (% CV) was 8.5%. Conclusions This study of leflunomide in patients using the drug clinically indicated a concentration-effect relationship. From our data, a plasma A77 1726 concentration of 50 mg l(-1) is more likely to indicate someone with less active disease than is a concentration around 30 mg l(-1). The marked variability in pharmacokinetics suggests a place for individualized dosing of leflunomide in RA therapy.