985 resultados para Hawking, Stephen


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O texto analisa a cultura de gestão e do desempenho como duas das principais tecnologias da reforma educacional que envolve a utilização calculada de técnicas e artefatos para organizar forças humanas e capacidades em redes de poder, as quais terminam por sonegar o espaço à constituição da identidade profissional dos professores como prática ético-cultural.

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Este artigo aborda a construção do protagonismo juvenil no âmbito da reforma do ensino médio, discutindo resultados parciais de pesquisa mais ampla, os quais focalizaram cinco escolas em dois estados brasileiros. O objetivo geral da investigação foi verificar como as escolas interagiam com as diretrizes oficiais que propõem a participação efetiva de alunos e dos pais na dinâmica escolar e quais são as mediações que articulam os microprocessos institucionais às orientações políticas e sociais mais abrangentes. Este texto, no entanto, analisa apenas o espaço que o pretendido desenvolvimento do protagonismo juvenil ocupa na trama da micropolítica escolar e, para isso, vale-se de conceitos de Stephen J. Ball como tentativa de "ler" a intrincada rede de relações intramuros que ressignifica as prescrições de órgãos centrais.

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Wilfred Carr, professor de la Divisió d'Educació de la Universitat de Sheffield del Regne Unit, és un deis representants més destacats de la Filosofia Crítica de l'Educació. A Espanya sobretot és conegut pel Ilibre (juntament amb Stephen Kemmis) 'Teoría crítica de la enseñanza', publicat per l'editorial Martínez Roca, i per una altre de més recent, 'Hacia una ciencia crítica de la educación', publicat per l'editorial Laertes. A més, ha participat en nombrosos congressos i seminaris, entre els quals podem destacar l'aportació que va fer al Congrés Internacional de Filosofia de l'Educació reunit a Madrid el 1988 i que fou publicada per la UNED al volum d'actes.

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Pieces of Iowa’s Past, published by the Iowa State Capitol Tour Guides weekly during the legislative session, features historical facts about Iowa, the Capitol, and the early workings of state government. All historical publications are reproduced here with the actual spelling, punctuation, and grammar retained. January 16, 2013 THIS WEEK: Iowa Senator James Harlan Becomes U.S. Senator BACKGROUND: Fifth Iowa General Assembly The Fifth Iowa General Assembly convened December 4, 1854, and adjourned January 26, 1855, a 54-day session. The Democrats numbered 17 members in the Senate and 31 members in the House. The Whigs held 14 seats in the Senate and 40 seats in the House—a total of 102 members. Iowa’s population at the 1850 census was 192,214. Iowa’s President of the Senate was Maturin Fisher and the Speaker of the House of Representatives was Rueben Noble. During the Fifth General Assembly, Stephen P. Hempstead finished his term as Governor and James W. Grimes was sworn in as Iowa’s third governor.

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Les recherches qualitatives dans les sciences de la santé sont de plus en plus nombreuses, cependant elles restent difficiles à publier et font souvent l'objet d'une moindre reconnaissance de la part des commanditaires et/ou des experts des revues. Devant cet état de fait, les chercheurs anglo-saxons ont développé un ensemble de grilles et critères qui devraient permettre d'établir les « standards » de qualité d'une recherche qualitative. Dans un premier temps, les auteurs proposent un bref état des lieux concernant les critères de qualité de la recherche qualitative dans les sciences de la santé. Dans un deuxième temps, ils présentent huit grilles, dont la traduction française est inédite, issues de la psychologie/psychiatrie et de la médecine générale. Les auteurs mettent en perspective ces grilles et montrent les difficultés à trouver des accords dans les définitions des critères entre les divers auteurs. Ces difficultés mettent en évidence l'écart entre ces grilles tant au point de vue de l'épistémologie qui les sous-tend, qu'au point de vue des critères retenus (nombre, type, forme, contenus). Les différences entre elles correspondent à la diversité des paradigmes auxquels se réfèrent les créateurs des grilles, sans jamais le mentionner explicitement dans leurs textes de référence. Les auteurs concluent que l'augmentation des travaux de recherche et des publications de type qualitatif n'a pas permis de dépasser les difficultés à établir des critères définis et partagés, et que cette grande hétérogénéité des concepts soulève des problèmes majeurs, non seulement méthodologiques, mais surtout épistémologiques et théoriques.

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no abstract

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Pinus caribaea var. hondurensis (Sénécl) Barr. & Golf. is a tropical pine that naturally occurs in lowland areas of Belize, El Salvador, Guatemala, Honduras, Nicaragua, and eastern Mexico. It has been one of the most studied tropical pines and the one with the most commercial importance in Brazil. The objective of this work was to select the best provenances for plantations and best trees in families for the establishment of seed orchards. For that a trial with five provenances and 47 open-pollinated families was planted near Planaltina, Federal District, in the Cerrado Region of Brazil. The provenances tested were Poptun (Guatemala), Gualjoco, Los Limones, El Porvenir and Santa Cruz de Yojoa (Honduras) and assessed at 12 years of age. Poptun and Gualjoco had larger volume, and Los Limones and El Porvenir the lowest incidence of forks and foxtails. Individual tree heritabilities for volume, stem form and branch diameter were 0.34, 0.06, and 0.26 respectively. More than 90% of the trees had defects, common in unimproved P. caribaea. Selection criteria for quality traits need to be relaxed in the first generation of breeding to allow for larger genetic gains in productivity. Results from this test compared with P. caribaea var. hondurensis trials in other Brazilian, Colombian and Venezuelan sites suggest that provenance x site and family x site interactions are not as strong as in other pine species.

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BACKGROUND: In Fabry nephropathy, alpha-galactosidase deficiency leads to accumulation of glycosphingolipids in all kidney cell types, proteinuria and progressive loss of kidney function. METHODS: An international working group of nephrologists from 11 Fabry centres identified adult Fabry patients, and pathologists scored histologic changes on renal biopsies. A standardized scoring system was developed with a modified Delphi technique assessing 59 Fabry nephropathy cases. Each case was scored independently of clinical information by at least three pathologists with an average final score reported. RESULTS: We assessed 35 males (mean age 36.4 years) and 24 females (43.9 years) who mostly had clinically mild Fabry nephropathy. The average serum creatinine was 1.3 mg/dl (114.9 micromol/l); estimated glomerular filtration rate was 81.7 ml/min/1.73 m(2) and urine protein to creatinine ratio was 1.08 g/g (122.0 mg/mmol). Males had greater podocyte vacuolization on light microscopy (mean score) and glycosphingolipid inclusions on semi-thin sections than females. Males also had significantly more proximal tubule, peritubular capillary and vascular intimal inclusions. Arteriolar hyalinosis was similar, but females had significantly more arterial hyalinosis. Chronic kidney disease stage correlated with arterial and glomerular sclerosis scores. Significant changes, including segmental and global sclerosis, and interstitial fibrosis were seen even in patients with stage 1-2 chronic kidney disease with minimal proteinuria. CONCLUSIONS: The development of a standardized scoring system of both disease-specific lesions, i.e. lipid deposition related, and general lesions of progression, i.e. fibrosis and sclerosis, showed a spectrum of histologic appearances even in early clinical stage of Fabry nephropathy. These findings support the role of kidney biopsy in the baseline evaluation of Fabry nephropathy, even with mild clinical disease. The scoring system will be useful for longitudinal assessment of prognosis and responses to therapy for Fabry nephropathy.

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The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in 1,047 cases and 988 controls from the Spanish Bladder Cancer (SBC)/EPICURO Study. A preliminary exploration with the widely used univariate logistic regression approach did not identify any significant SNP after correcting for multiple testing. We further applied two more comprehensive methods to capture the complexity of bladder cancer genetic susceptibility: Bayesian Threshold LASSO (BTL), a regularized regression method, and AUC-Random Forest, a machine-learning algorithm. Both approaches explore the joint effect of markers. BTL analysis identified a signature of 37 SNPs in 34 genes showing an association with bladder cancer. AUC-RF detected an optimal predictive subset of 56 SNPs. 13 SNPs were identified by both methods in the total population. Using resources from the Texas Bladder Cancer study we were able to replicate 30% of the SNPs assessed. The associations between inflammatory SNPs and bladder cancer were reexamined among non-smokers to eliminate the effect of tobacco, one of the strongest and most prevalent environmental risk factor for this tumor. A 9 SNP-signature was detected by BTL. Here we report, for the first time, a set of SNP in inflammatory genes jointly associated with bladder cancer risk. These results highlight the importance of the complex structure of genetic susceptibility associated with cancer risk.