Attention-Deficit/Hyperactivity Disorder and antidepressants and prescription medications: A pilot study

Background. Attention Deficit-Hyperactivity Disorder (AD/HD) diagnosis in children and adolescents has been on the rise over the last couple of decades and a multitude of studies have been conducted in an aim to better understand the disease. Literature has explored the role of several factors suspected of contributing to development of the disease, including: prenatal smoking exposures, environmental exposures, and low-birth weight. However, there is very limited reporting of fetal/infant exposure to antidepressants and prescription medications and the long-term behavioral outcomes, namely development of AD/HD. The purpose of this study was to evaluate the relationship between mother's exposure to prescription medications and/or antidepressants around the time of conception, during pregnancy, or while breastfeeding and the development of Attention-Deficit/Hyperactivity Disorder in offspring. Methods. Secondary analysis of data from a case-control study was performed. Exposure histories were collected for the mother and offspring. Data were collected using a secure, confidential, self-report, online survey to evaluate the relationship between antidepressant and/or prescription medication exposure and the development of AD/HD. The period of exposure to these drugs was defined as: around the time of conception, during pregnancy, or while breastfeeding. Cases were defined as a child who had been diagnosed with AD/HD. Controls were defined as a child who had not been diagnosed with AD/HD. Results. Prescription medication and antidepressant medication exposures around the time of conception, during pregnancy, or while breastfeeding were not associated with development of AD/HD. However, traumatic brain injury (OR=2.77 (1.61–4.77)) and preterm birth (OR=1.48 (1.04–2.12)) were identified as potential risk factors. These results support existing literature on AD/HD, but future work must be undertaken to better evaluate fetal/infant medication exposures and long-term behavioral outcomes.^

Frequency, severity and distress of dialysis-related symptoms reported by patients on hemodialysis

Purpose. To determine which symptoms are the most reported, occur most frequently, have the greatest severity, and cause the most bother for hemodialysis (HD) patients and to determine if the symptoms experienced differ between the first (HD 1) and second (HD 2) treatments of the week. ^ Design. An observational, comparative design was used to determine participants' HD symptoms experience on HD 1 and HD 2, and the effect of the symptom experience on Quality of Life (QOL). One hundred subjects were recruited from five dialysis centers. ^ Methods. The adapted Dialysis Frequency, Severity and Symptom Burden Index (DFSSBI) and the Medical Outcomes Study Short Form 36 (MOS SF 36) were administered (N = 99) on HD 1 and the DFSSBI again on HD 2. Data were analyzed for significance among symptoms experience test scores in relation to HD 1 and HD 2, QOL, and gender and age. ^ Results. Of 31 symptoms assessed, respondents reported an average of 9.69 symptoms on HD 1 and 7.51 symptoms on HD 2. Overall, more symptoms were reported, and were more frequent, severe and bothersome on HD 1 when the level of metabolic waste is highest. The most reported symptoms included tiredness, dry skin, difficulty falling asleep, itching, numbness/tingling, difficulty staying asleep, decreased interest in sex, and bone/joint pain. Females scored consistently higher than males in the four symptom dimensions. The respondents reported about the same as the population norm (50) on the physical component summary score of the MOS SF 36 and higher than the norm (65.23) on the mental component summary score. ^ Conclusion. The study findings highlighted the fact that hemodialysis patients experience multiple symptoms that can be frequent, severe, and bothersome. Interventions should be developed and tested to reduce symptom burden and improve QOL. ^

Hospital district viability and Medicaid /market changes

Hospital districts (HD) that serve the uninsured and the needy face new challenges with the implementation of Medicaid managed. The potential loss of Medicaid patients and revenues may affect the ability to cost-shift and subsequently decrease the ability of the HD to meet its legal obligation of providing care for the uninsured. ^ To investigate HD viability in the current market, the aims of this study were to: (1) describe HD's environment, (2) document the HDs strategic response, (3) document changes in the HD's performance (patient volume) and financial status, and (4) determine whether relationships or trends exist between HD strategy, performance and financial status. ^ To achieve these aims, three Texas HDs (Fort Worth, Lubbock, and San Antonio) were selected to be evaluated. For each HD four types of strategic responses were documented and evaluated for change. In addition, the ability of each HD to sustain operations was evaluated by documenting performance and financial status changes (patient volume and financial ratios). A pre-post case study design method was used in which the Medicaid managed care “rollout'” date, at each site, was the central date. First, a descriptive analysis was performed which documented the environment, strategy, financial status, and patient volume of each hospital district. Second, to compare hospital districts, each hospital district was: (i) classified by a risk index, (ii) classified by its strategic response profile, and (iii) given a performance score based upon pre-post changes in patient volume and financial indicators. ^ Results indicated that all three HDs operate in a high risk environment compared to the rest of the nation. Two HDs chose the “Status Quo” response whereas one HD chose the “Competitive Proactive” response. Medicaid patient volume decreased in two of three HDs whereas indigent patient volume increased in two of the three (an indication of increasing financial risk). Total patient revenues for all HDs increased over the study period; however, the rate of increase slowed for all three after the Medicaid rollout date. All HDs experienced a decline in financial status between pre-post periods with the greatest decline observed in the HD that saw the greatest increase in indigent patient volume. ^ The pre-post case study format used and the lack of control study sites do not allow for assignment of causality. However, the results suggest possible adverse effects of Medicaid managed care and the need for a larger study, based on a stronger evaluation research design. ^

Ciruelas bajo tela antigranizo : : efecto sobre la calidad

Se evaluó la influencia de la tela antigranizo en la calidad en cosecha y postcosecha de ciruelas japonesas (Prunus salicina Lindl.) cv. Angeleno. Se cosechó fruta de plantas bajo tela y sin tela en dos fechas. Las determinaciones de madurez y calidad se hicieron en cosecha, después de 45 y 60 días de almacenamiento refrigerado (0 °C y HR = 85 %) y luego de un período de maduración a 20 °C. Parámetros considerados: tamaño, color, firmeza de pulpa, contenido de sólidos solubles, pH, acidez titulable, relación CSS/AT, deshidratación y desórdenes fisiológicos (harinosidad). Se realizó un análisis factorial teniendo en cuenta tela antigranizo (T), fecha de cosecha (F) y período de almacenamiento refrigerado (P). Los factores T y F actuaron sobre el tamaño, color de piel, firmeza de pulpa, CSS, AT y CSS/AT en las evaluaciones realizadas en cosecha. Después del período de maduración, los factores T, F y P tuvieron principalmente efecto en la firmeza de pulpa, AT y CSS/AT. La fecha de cosecha y el período de almacenamiento tuvieron una marcada influencia sobre la incidencia de harinosidad.

Cultivo en maceta de Iris xiphium L. (Iris de Holanda) con diferentes concentraciones de humus de lombriz y sus lixiviados

Se evaluaron tres variedades de Iris xiphium L. cultivadas en maceta en cuatro proporciones de humus de lombriz y se aplicaron los lixiviados diluidos como bioabono foliar. El experimento se realizó en un diseño completamente al azar con arreglo trifactorial y se midieron ocho variables: longitud de tallo (LT), longitud de botón (LB), longitud de flor (LF), diámetro de botón (DB), diámetro de flor (DF), biomasa (B), área foliar (AF) y días de cosecha (DDC). Los resultados indicaron que la variedad Telstar resultó ser la más precoz. El mejor tratamiento en dicha variedad para las variables LT, LB, B, DF y DDC correspondió a la proporción 30/70 (% lombrihumus / % suelo) y la dilución 1:10 de lixiviado; el segundo mejor tratamiento fue en la variedad Discovery en la proporción 40/60 (%lombrihumus / %suelo) y dilución 1:10 de lixiviado para las variables LT, AF y B. El presente trabajo aporta nueva información en cuanto al uso de sustratos y abono foliar orgánicos para el manejo sustentable, con bajo impacto ambiental, en cultivos florícolas.

Imputación de genotipos y detección de regiones genómicas aditivas para caracteres de crecimiento y deposición de grasa en una población cruza porcina

Los estudios de asociación genómica (GWAS) llevan consigo un algo costo monetario, y a su vez requieren algoritmos complejos de análisis de información que consumen tiempo y memoria computacional. En este sentido, el objetivo principal de esta tesis es presentar un esquema de genotipado apropiado para poblaciones cruza, junto con un algoritmo eficiente para GWAS de caracteres complejos productivos. Inicialmente, se presenta un esquema de genotipado que maximiza la exactitud de imputación de genotipos en alta densidad (HD) a partir de paneles de baja densidad (LowD), reduciendo el costo de genotipificación. Posteriormete, se propone un algoritmo que facilita identificar regiones genómicas que explican parte de la variabilidad de un carácter, reduciendo la tasa de falsos positivos, el tiempo de cálculo y el requerimiento de memoria RAM. De igual manera, el algoritmo evalúa segmentos candidatos a partir de las posiciones detectadas significativas y calcula la fracción de la varianza aditiva total explicada por cada segmento. Finalmete se presentan estudios de asociación para características de crecimiento y deposición de grasa, empleando el algoritmo propuesto junto con genotipos imputados en HD. La implementación de dicho algoritmo permite identificar regiones significativas relevantes y genes candidatos que explican parte de la variación de los caracteres evaluados. En conclusión, la tesis propone un enfoque estructurado, práctico y eficiente para la realización de GWAS de caracteres complejos aplicado en poblaciones experimentales con fines productivos.

Geophysical investigations in the European Alps

Joint interpretation of magnetotelluric and geomagnetic depth sounding data in the western European Alps offer new insights into the conductivity structure of the Earth's crust and mantle. This first large scale electromagnetic study in the Alps covers a cross-section from Germany to northern Italy and shows the importance of the alpine mountain chain as an interrupter of continuous conductors. Poor data quality due to the highly crystalline underground is overcome by Remote Reference and Robust Processing techniques. 3d-forward-modelling reveals on the one hand interrupted dipping crustal conductors with maximum conductance of 4960 S and on the other hand a lithosphere thickening up to 208 km beneath the central western Alps. Graphite networks arising from Paleozoic sedimentary deposits are considered to be accountable for the occurrence of high conductivity and the distribution pattern of crustal conductors. The influence of huge sedimentary molasse basins on the electromagnetic data is suggested to be minor compared with the influence of crustal conductors. In conclusion, electromagnetic results can be attributed to the geological, tectonic and palaeogeographical background. Dipping direction (S-SE) and maximum angle (10.1°) of the northern crustal conductor reveal the main thrusting conditions beneath the Helvetic Alps whereas the existence of a crustal conductor in the Briançonnais supports theses about its palaeographic belonging to the Iberian Peninsula.

Geochemical investigations of volcanic ash layers from ODP Leg 119

Geochemical investigations were carried out on 19 discrete ash layers and on 42 dispersed ash accumulations in Oligocene to Pleistocene sediments from Sites 736, 737, 745, and 746 of ODP Leg 119 (Kerguelen Plateau in the southern Indian Ocean). The chemical data obtained from more than 500 single-grain glass analyses allow the characterization of two dominant petrographic rock series. The first consists of transitional- to alkali-basalts, the second mainly of trachytes with subordinated alkali-rhyolites and rhyolites. Chemical correlation with possible source areas indicates that the tephra layers from the northern Kerguelen Plateau Sites 736 and 737 were probably erupted from the nearby Kerguelen Islands. The investigated ash layers clearly reflect the Oligocene to recent changes in the composition of the volcanic material recorded from the Kerguelen Islands. The dispersed ashes from Sites 745 and 746 in the Australian-Antarctic Basin display almost the same range in chemical compositions as those from the north. Heard Island and other sources may have contributed to their formation, in addition to the Kerguelen Islands. Dispersed ash of calc-alkaline composition is most probably derived from the South Sandwich island arc, indicating sea-ice rafting as an important mechanism of transport.

Electrical resistivity, formation factors, and sound velocity at DSDP Holes 75-530A and 75-530B

From 0 to 277 m at Site 530 are found Holocene to Miocene diatom ooze, nannofossil ooze, marl, clay, and debrisflow deposits; from 277 to 467 m are Miocene to Oligocene mud; from 467 to 1103 m are Eocene to late Albian Cenomanian interbedded mudstone, marlstone, chalk, clastic limestone, sandstone, and black shale in the lower portion; from 1103 to 1121 m are basalts. In the interval from 0 to 467 m, in Holocene to Oligocene pelagic oozes, marl, clay, debris flows, and mud, velocities are 1.5 to 1.8 km/s; below 200 m velocities increase irregularly with increasing depth. From 0 to 100 m, in Holocene to Pleistocene diatom and nannofossil oozes (excluding debris flows), velocities are approximately equivalent to that of the interstitial seawater, and thus acoustic reflections in the upper 100 m are primarily caused by variations in density and porosity. Below 100 or 200 m, acoustic reflections are caused by variations in both velocity and density. From 100 to 467 m, in Miocene-Oligocene nannofossil ooze, clay, marl, debris flows, and mud, acoustic anisotropy irregularly increases to 10%, with 2 to 5% being typical. From 467 to 1103 m in Paleocene to late Albian Cenomanian interbedded mudstone, marlstone, chalk, clastic limestone, and black shale in the lower portion of the hole, velocities range from 1.6 to 5.48 km/s, and acoustic anisotropies are as great as 47% (1.0 km/s) faster horizontally. Mudstone and uncemented sandstone have anisotropies which irregularly increase with increasing depth from 5 to 10% (0.2 km/s). Calcareous mudstones have the greatest anisotropies, typically 35% (0.6 km/s). Below 1103 m, basalt velocities ranged from 4.68 to 4.98 km/s. A typical value is about 4.8 km/s. In situ velocities are calculated from velocity data obtained in the laboratory. These are corrected for in situ temperature, hydrostatic pressure, and porosity rebound (expansion when the overburden pressure is released). These corrections do not include rigidity variations caused by overburden pressures. These corrections affect semiconsolidated sedimentary rocks the most (up to 0.25 km/s faster). These laboratory velocities appear to be greater than the velocities from the sonic log. Reflection coefficients derived from the laboratory data, in general, agree with the major features on the seismic profiles. These indicate more potential reflectors than indicated from the reflection coefficients derived using the Gearhart-Owen Sonic Log from 625 to 940 m, because the Sonic Log data average thin beds. Porosity-density data versus depth for mud, mudstone, and pelagic oozes agree with data for similar sediments as summarized in Hamilton (1976). At depths of about 400 m and about 850 m are zones of relatively higher porosity mudstones, which may suggest anomalously high pore pressure; however, they are more probably caused by variations in grain-size distribution and lithology. Electrical resistivity (horizontal) from 625 to 950 m ranged from about 1.0 to 4.0 ohm-m, in Maestrichtian to Santonian- Coniacian mudstone, marlstone, chalk, clastic limestone, and sandstone. An interstitial-water resistivity curve did not indicate any unexpected lithology or unusual fluid or gas in the pores of the rock. These logs were above the black shale beds. From 0 to 100 m at Sites 530 and 532, the vane shear strength on undisturbed samples of Holocene-Pleistocene diatom and nannofossil ooze uniformly increases from about 80 g/cm**2 to about 800 g/cm**2. From 100 to 300 m, vane shear strength of Pleistocene-Miocene nannofossil ooze, clay, and marl are irregular versus depth with a range of 500 to 2300 g/cm**2; and at Site 532 the vane shear strength appears to decrease irregularly and slightly with increasing depth (gassy zone). Vane shear strength values of gassy samples may not be valid, for the samples may be disturbed as gas evolves, and the sediments may not be gassy at in situ depths.

Paleoelevations in the Pacific Ocean 35 million years ago

Data from deep sea drilling, linear magnetic anomalies and bathymetric measurements together with age and morphometric characteristics of seamounts have been used to construct a paleobathymetric map of the oceans 35 million years ago. A brief analysis of these results is presented.