[Voyage en Italie : 1824-1830]. , Maison du Tasse à Sorrento : [vue perspective de la cour, plan du rez-de-chaussée, plan du premier étage] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 677

[Voyage en Italie : 1824-1830]. , Maison du Tasse à Sorrento : [vue perspective] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 676

Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation.

Fungi are primitive eukaryotes and have adapted to a variety of niches during evolution. Some fungal species may interact with other life forms (plants, insects, mammals), but are considered as pathogens when they cause mild to severe diseases. Chemical control strategies have emerged with the development of several drugs with antifungal activity against pathogenic fungi. Antifungal agents have demonstrated their efficacy by improving patient health in medicine. However, fungi have counteracted antifungal agents in several cases by developing resistance mechanisms. These mechanisms rely on drug resistance genes including multidrug transporters and drug targets. Their regulation is crucial for the development of antifungal drug resistance and therefore transcriptional factors critical for their regulation are being characterized. Recent genome-wide studies have revealed complex regulatory circuits involving these genetic and transcriptional regulators. Here, we review the current understanding of the transcriptional regulation of drug resistance genes from several fungal pathogens including Candida and Aspergillus species.

[Voyage en Italie : 1824-1830]. , [Caisson et ornement au] Colisée : [vue perspective d'un ornement non identifié, projection et coupe d'un caisson] : [dessin] / [Henri Labrouste]

Référence bibliographique : Weigert, 500a

[Voyage en Italie : 1824-1830]. , Borne militaire au Palais Giustiniani : [vue perspective, deux profils de détails] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 577

[Voyage en Italie : 1824-1830]. , [Petit temple circulaire] Ext. d'un manuscrit de la Bibliothèque Barberine. Rome : [vue perspective] : [dessin] / [Henri Labrouste]

Référence bibliographique : Weigert, 570

[Voyage en Italie : 1824-1830]. , [Vue d'un petit temple circulaire, avec une figure en pleurs, intitulé] Luctus Funebris. In aedibus barberinis : [vue perspective] : [dessin] / [Henri Labrouste]

Référence bibliographique : Weigert, 571

[Voyage en Italie : 1824-1830]. , [Cippe de C. Domitio F. Palveri à la] Villa Albani : [détail, vue perspective] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 622

Citizen participation and the Lisbon Treaty : A legal perspective

How to "bring the [European] Union closer to its citizens" is a vexed and vital problem of European integration. Article 11 TEU on participatory democracy, recently introduced by the Lisbon Treaty, is meant to be part of the solution. The EU Economic and Social Committee has gone so far as to define this provision "a milestone on the road to a people's Europe that is real and feasible". This appears to be an overly optimistic assessment - partly because art. 11 relies heavily on the involvement of civil society organisations, which political science literature suggests is conceptually and/or practically irrelevant to citizen involvement; partly because it largely formalizes participatory practices that have been in existence for years without cognizable effects on citizen participation; and partly because even its most innovative element - the European citizens' initiative (ECI) - does not bring significant changes to the Union's constitutional arrangements in terms of redistributing decision-making power. In addition to that, secondary legislation places significant hurdles on the submission of ECIs and might prevent or delay their becoming a standard democratic practice. This is not to say that art. 11 TEU has no potential at all. Its insertion in the Treaty might provide impetus to rethink and develop past participatory practices, such as horizontal civil dialogue. Moreover, the effects of "popular input" in the form of ECIs on EU institutional dynamics is as yet unknown - and perhaps not negligible, to judge from the keen interest that the European Parliament and other bodies have demonstrated in "appropriating" it as a political asset. Finally, art. 11 raises the stakes of the Union's democratic challenge and might pressure EU institutions to make full use of its potential. Or, if eventually proved inadequate, art. 11 might constitute a constitutional experiment on the way to meaningful forms of direct democracy at EU level.

ISBN (international standard book number) -an international perspective

Esitelmä Suomen ISBN-keskus 30 vuotta -juhlassa Helsingin yliopistossa 7.11.2002

La police scientifique au-delà de ses frontières actuelles: la perspective de nouvelles connaissances

Essentiellement centrée sur le développement de nouvelles techniques et instrumentations, ainsi que sur la structuration de moyens de preuve et leur quantification pour la justice, la communauté forensique tend à se renfermer sur la reproduction de ses propres formats. Elle en oublie les fondements de la police scientifique, elle qui dès ses prémices a prôné l'application d'une démarche scientifique pour l'exploitation des traces matérielles lors d'activités criminelles, mais également au-delà, comme vecteur de connaissance sur des problèmes de nature réglementaire, civile, sécuritaire, de santé publique, etc. Depuis quelques années, un mouvement s'est amorcé, tentant de se réapproprier les schémas de construction transdisciplinaire de connaissance mêlant la science forensique, entre autres, à la criminologie. L'exploitation des traces matérielles et de l'information qu'elles peuvent convoyer, peut dévoiler de nouvelles perspectives : cristalliser des indicateurs pour comprendre l'ampleur et la dynamique de certains phénomènes, ou servir de base à une étude phénoménologique par la reconstruction et la résolution de cas. Cet article traite de cette vision de la police scientifique, au-delà de ses frontières actuelles, et en propose des illustrations concrètes comme les travaux relatifs à l'utilisation de traces de stupéfiants dans les eaux usées en tant qu'indicateurs d'une tendance, ou les enseignements découlant d'investigations menées suite à des sinistres fatals dans des établissements carcéraux.

Dynamics of flow: a nonlinear perspective

The aims of this study are to consider the experience of flow from a nonlinear dynamics perspective. The processes and temporal nature of intrinsic motivation and flow, would suggest that flow experiences fluctuate over time in a dynamical fashion. Thus it can be argued that the potential for chaos is strong. The sample was composed of 20 employees (both full and part time) recruited from a number of different organizations and work backgrounds. The Experience Sampling Method (ESM) was used for data collection. Once obtained the temporal series, they were subjected to various analyses proper to the com- plexity theory (Visual Recurrence Analysis and Surrogate Data Analysis). Results showed that in 80% of the cases, flow presented a chaotic dynamic, in that, flow experiences delineated a complex dynamic whose patterns of change were not easy to predict. Implications of the study, its limitations and future research are discussed.

Perspective: from molecular endocrinology of mouse to genomic endocrinology of animals.

This short perspective explores some ways in which new genomic methodologies impact the study of endocrine signaling. Emphasis is put on the impact of studying species which are not molecular biology models. This opens the door to using knowledge molecular endocrinology in areas of biology as distant as conservation biology, as well as enriching endocrinology with information from biodiversity and natural variation.

The Interplay of Mastery and Performance Goals in Social Comparison: A Multiple-Goal Perspective.

Régner, Escribe, and Dupeyrat (2007) recently demonstrated that not only performance-approach and performance-avoidance goals (respectively, the desire to outperform others and not to be outperformed by others) but also mastery goals (the desire to acquire knowledge) were related to social comparison orientation (SCO, the tendency to search for social comparison information). In the present article, the possibility of a link between mastery goals and social comparison that depends on the level of performance-approach goals-a possibility supported by a multiple-goal perspective-was tested by examining the interaction effect between mastery and performance-approach goals. This is an important endeavor, as educational settings are rarely free from performance-approach goals, even when mastery goals are promoted. In Study 1, we tested self-set achievement goals (mastery, performance-approach, and performance-avoidance goals) as predictors of SCO; the interaction between mastery goals and performance-approach goals indicated that the higher the performance-approach goal endorsement, the stronger the link between mastery goals and SCO. In Study 2, we manipulated goal conditions; mastery goals predicted interest in social comparison in the performance-approach goal condition only. Results are discussed in terms of the importance of multiple-goal pursuit in academic settings. (PsycINFO Database Record (c) 2009 APA, all rights reserved)