Monday Morning Eye Opener, December 07, 2015

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, December 14, 2015

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, December 21, 2015

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, January 4, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, January 11, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Dimorphic turning bias in spontaneous rotational movement

Turning biases have been associated with unbalanced hemispheric dopaminergic activity, and this activity has been correlated with cue-directed behaviors. Moreover, a sexual differentiation in hippocampal dopaminergic receptors following learning has been shown. In humans, pointing responses towards the starting point is commonly used to assess the accuracy of direction estimation after locomotion. Thus, it may be of interest for the field of spatial cognition to explore human sex differences in spontaneous turning bias when a body rotation is required. To this end, male and female blindfolded subjects were guided in a linear displacement and asked to rotate in order to point in the direction of the starting position. The main finding was a massive difference between men and women. 80% of women showed a turning bias to the right when 69% of men showed a bias to the left. Moreover, these preferences were not correlated with handedness. These results suggest basic preferences associated to sex might influence male and female performance in spatial cognition. They also suggest experimental procedures may be biased in favor of male or female strategies. Therefore, such preferences should be considered in order to gain further insight into the development of more balanced procedures.

Monday Morning Eye Opener, January 25, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, February 1, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, February 8, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, February 15, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, February 22, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Monday Morning Eye Opener, February 29, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Cyclosporine A delivery to the eye: a pharmaceutical challenge.

Systemic administration of cyclosporine A (CsA) is commonly used in the treatment of local ophthalmic conditions involving cytokines, such as corneal graft rejection, autoimmune uveitis and dry eye syndrome. Local administration is expected to avoid the various side effects associated with systemic delivery. However, the currently available systems using oils to deliver CsA topically are poorly tolerated and provide a low bioavailability. These difficulties may be overcome through formulations aimed at improving CsA water solubility (e.g. cyclodextrins), or those designed to facilitate tissue drug penetration using penetration enhancers. The use of colloidal carriers (micelles, emulsions, liposomes and nanoparticles) as well as the approach using hydrosoluble prodrugs of CsA have shown promising results. Solid devices such as shields and particles of collagen have been investigated to enhance retention time on the eye surface. Some of these topical formulations have shown efficacy in the treatment of extraocular diseases but were inefficient at reaching intraocular targets. Microspheres, implants and liposomes have been developed to be directly administered subconjunctivally or intravitreally in order to enhance CsA concentration in the vitreous. Although progress has been made, there is still room for improvement in CsA ocular application, as none of these formulations is ideal.

Monday Morning Eye Opener, March 7, 2016

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.