Manuel du libraire et de l'amateur de livres, contenant 1⁰ Un nouveau dictionnaire bibliographique ... 2⁰ Une table en forme de catalogue raisonné ... /

Dictionnaire de géographie ancienne et moderne a l'usage du libraire et de l'amateur de livres ... Par un bibliophile ... Paris, Firmin-Didot frères, fils et cie, 1870. (Half-title: Supplément au Manuel du libraire et de l'amateur de livres. Dedication signed "P.D." i.e. Pierre Deschamps)

Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy

Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. Methods and Findings: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 participants in 5 trials of more intensive versus less intensive statin therapy (median duration 5.1 years) were obtained. Reducing LDL-C with a statin for about 5 years had no effect on newly diagnosed cancer or on death from such cancers in either the trials of statin versus control (cancer incidence: 3755 [1.4% per year [py]] versus 3738 [1.4% py], RR 1.00 [95% CI 0.96-1.05]; cancer mortality: 1365 [0.5% py] versus 1358 [0.5% py], RR 1.00 [95% CI 0.93-1.08]) or in the trials of more versus less statin (cancer incidence: 1466 [1.6% py] vs 1472 [1.6% py], RR 1.00 [95% CI 0.93-1.07]; cancer mortality: 447 [0.5% py] versus 481 [0.5% py], RR 0.93 [95% CI 0.82-1.06]). Moreover, there was no evidence of any effect of reducing LDL-C with statin therapy on cancer incidence or mortality at any of 23 individual categories of sites, with increasing years of treatment, for any individual statin, or in any given subgroup. In particular, among individuals with low baseline LDL-C (<2 mmol/L), there was no evidence that further LDL-C reduction (from about 1.7 to 1.3 mmol/L) increased cancer risk (381 [1.6% py] versus 408 [1.7% py]; RR 0.92 [99% CI 0.76-1.10]). Conclusions: In 27 randomised trials, a median of five years of statin therapy had no effect on the incidence of, or mortality from, any type of cancer (or the aggregate of all cancer).

(Table 1) Age determination of sediment cores EW9302-JPC1 and EW9302-JPC2

Results from two deep sea cores from northeast of Newfoundland at 1251 and 2527 m water depth, respectively, indicate that during the time period from 160,000 to 10,000 years BP, ice rafting events in the Labrador Sea were accompanied by rapid variations in deep and surface water circulation. Twelve ice-rafting events occurred, each coinciding with high concentrations of detrital carbonate and oxygen isotopic depletion of both surface and bottom waters. Eleven of these can be correlated with the North Atlantic Heinrich events H1-H11. The remaining very conspicuous ice-rafting event took place early in MIS substage 5e, at a time when the planktic faunal assemblage suggests marked warming of the sea surface. In the shallower core, benthic d13C values rise from a minimum during the deglaciation to peak substage 5e values following the last ice-rafting event, indicating that the ventilation of intermediate depths was renewed after the deglaciation was complete and continued throughout substage 5e. The benthic foraminifera suggest that this well-ventilated water mass was comparable to the modern Labrador Sea Water (LSW). The benthic faunas suggest that a relatively warm intermediate water mass entered the SE Labrador Sea during Heinrich events. Generally low benthic d13C values indicate that this water mass was poorly ventilated and rich in inorganic nutrients. Isotope data and benthic faunal distributions indicate that North Atlantic Deep Water (NADW) formed in the Norwegian-Greenland Sea reached the SE Labrador Sea between the Heinrich events.

(Table 1) Phosphorus and carbon chemistry of ODP Holes 169-1033B and 169-1034B

Uncertainty currently exists about the removal of carbon (C) and phosphorus (P) from the oceanic reservoir, especially in low oxygen settings. In this paper, the cycling of C and P is examined in sediments from the anoxic Saanich Inlet, cored by Ocean Drilling Program (ODP) Leg 169S in 1996 at two sites. Although Corg/Porg ratios are high and increase with depth in the Saanich Inlet, this effect is due largely to a remobilization of P from an organic matter sink to an authigenic sink. Reducible sedimentary components act as temporary shuttles in this process even in this anoxic setting, with the ultimate burial sink for the remobilized P being carbonate fluorapatite. The effective Corg/Preactive molar ratio appears to be about 150-200, indicating some preferential loss of P compared to C during organic matter degradation, but not approaching previously reported values of over 3000 in black shales. Reactive P accumulation rates in this basin range from 10,000-60,000 µmol/cm**2/kyr, greatly exceeding the range of 500-8000 µmol/cm**2/kyr found in most continental-margin settings, including regions of modern phosphogenesis. The initiation of marine sedimentation in the Saanich Inlet occurred after deglaciation, and the high rates of P burial seen here may provide an end-member example of the effects of sea level and margin sedimentation on the distribution of P within the marine P cycle.

Age determination of sediment core GIK16523-1

High-resolution studies of a planktonic foraminifer core record from the South China Sea (SCS) (31KL: 18°45.4'N, 115°52.4'E, water depth 3360 m) reveal changes driven by ice-volume forcings in the climate of the East Asian monsoon in the western Pacific marginal sea during the late Quaternary. The analyses of planktonic foraminifer faunal abundance data from the core indicate significant variations in the relative abundances of the dominant taxa over the past 100,000 years since the isotope stage 5. The transfer function estimates of faunal sea surface temperatures (SST) correlate well with a long-term (104-105 years) trend of global glaciation. About 65,000 years ago, there was an observable change in the mode of SST variability as many low-latitude records have shown. These findings suggest that the SCS surface circulation and the East Asian winter monsoon systems are mainly driven by variations in global glaciation levels. The association of surface ocean cooling in the SCS with global climatic events suggests that fluctuations in the strength of the East Asian winter monsoon may be linked to shifts in the latitudinal position of the westerly winds and the Siberian high-pressure system.

Sea-bed photographs (benthos) from the AWI-Hausgarten area along OFOS profile PS62/191-1

Although the use of deep-sea imagery considerably increased during the last decades, reports on nekton falls to the deep seafloor are very scarce. Whereas there are a few reports describing the finding of whale carcasses in the deep north-eastern and south-eastern Pacific, descriptions of invertebrate or vertebrate food-falls at centimetre to metre scale are extremely rare. After 4 years of extensive work at a deep-sea long-term station in northern polar regions (AWI-"Hausgarten"), including large-scale visual observations with various camera systems covering some 10 000 m2 of seafloor at water depths between 1250 and 5600 m, this paper describes the first observation of a fish carcass at about 1280 m water depth, west off Svålbard. The fish skeleton had a total length of 36 cm and an approximated biomass of 0.5 kg wet weight. On the basis of in situ experiments, we estimated a very short residence time of this particular carcass of about 7 h at the bottom. The fast response of the motile deep-sea scavenger community to such events and the rapid utilisation of this kind of organic carbon supply might partly explain the extreme rarity of such an observation.