Executive Order Number Thirty Two, July 7, 1987

Create the Governor's Alliance on Substance Abuse within the Department of Public Health.

Executive Order Number Thirty Three, August 21, 1987

Continue the TIM Council.

Executive Order Number Thirty Four, July 22, 1988

Provisions of Equal Empolyment Opportunity and Affirmation Action in State government enforced through the Iowa Department of Management.

Executive Order Number Thirty Five, September 27, 1988

Creates the Iowa Commission on Foreign Language Studies and International Education

Executive Order Number Thirty Six, Febraury 13, 1989

Iowa state government shall be models for developing and implementing comprehensive programs for waste reduction, recycling, and the use of recycled products.

Executive Order Number Thirty Seven, Febraury 13, 1989

State government shall be models for developing and implementing comprehensive programs for waste reduction, recycling, and the use of recycled products.

Executive Order Number Thirty Eight, March 17, 1989

In complaiance with the Drug Free Workplace Act of 1988, State of iowa is obliged to provide a drug and alcohol free environment including disciplinary action.

Executive Order Number Thirty Nine, September 12, 1989

Forms State hazard mitigation team, chaired by Department of Public Defense, Disaster Services Division, to determine capabilitites of State agencies, provide assistance, improve preparedness, response, and recovery from disasters.

Executive Order Number Forty, November 1, 1990

The Governor's Alliance on Substance Abuse is the designed agency to receive Drug Control& System Improvement Grant Program funding.

Executive Order Number Forty One, November 6, 1990

Empowers the Governor to accept retrocession of Federal jurisdiction if offered by appropriate federal authorities.

Executive Order Number Forty Two, July 1991

Invokes across-the-board budget reductions as determinded by the Governor.

Executive Order Number Forty Three, April 30, 1992

Invokes further budget cuts as determinded by the Governor.

Executive Order Number Forty Four, April 30, 1992

Rescinds Executive Order #46 and recommits efforts of the Executive branch and all department directors, member of governing boards and commissions, and other public officers affirmative action, discriminatory harrassment prevention, and cultural diversity.

Brain natriuretic peptide is able to stimulate cardiac progenitor cell proliferation and differentiation in murine hearts after birth.

Brain natriuretic peptide (BNP) contributes to heart formation during embryogenesis. After birth, despite a high number of studies aimed at understanding by which mechanism(s) BNP reduces myocardial ischemic injury in animal models, the actual role of this peptide in the heart remains elusive. In this study, we asked whether BNP treatment could modulate the proliferation of endogenous cardiac progenitor cells (CPCs) and/or their differentiation into cardiomyocytes. CPCs expressed the NPR-A and NPR-B receptors in neonatal and adult hearts, suggesting their ability to respond to BNP stimulation. BNP injection into neonatal and adult unmanipulated mice increased the number of newly formed cardiomyocytes (neonatal: +23 %, p = 0.009 and adult: +68 %, p = 0.0005) and the number of proliferating CPCs (neonatal: +142 %, p = 0.002 and adult: +134 %, p = 0.04). In vitro, BNP stimulated CPC proliferation via NPR-A and CPC differentiation into cardiomyocytes via NPR-B. Finally, as BNP might be used as a therapeutic agent, we injected BNP into mice undergoing myocardial infarction. In pathological conditions, BNP treatment was cardioprotective by increasing heart contractility and reducing cardiac remodelling. At the cellular level, BNP stimulates CPC proliferation in the non-infarcted area of the infarcted hearts. In the infarcted area, BNP modulates the fate of the endogenous CPCs but also of the infiltrating CD45(+) cells. These results support for the first time a key role for BNP in controlling the progenitor cell proliferation and differentiation after birth. The administration of BNP might, therefore, be a useful component of therapeutic approaches aimed at inducing heart regeneration.

Executive Order Number Forty Five, August 27, 1992

Orders the Department of Econmic Development to work with the Regional Coordinating Council.