Investigation of A High-Speed Law Enforcement Pursuit involving Toledo Police Department and the Tama County Sheriff's Office, 2002

Investigative report produced by Iowa Citizens' Aide/Ombudsman

Assessing High-Speed Internet Access in the State of Iowa: Fourth Assessment, December 2004

The primary objective of the Fourth Assessment is to evaluate the level of progress in the deployment of high-speed Internet technologies in the State of Iowa.

State of Iowa Annual Profile, 2004

Statewide data for Workforce Development.

Adair 2004 Annual County Profile, 2004

County Profile

Bremer 2004 Annual County Profile, 2004

County Profile

Adams 2004 Annual County Profile, 2004

County Profile

Allamakee 2004 Annual County Profile, 2004

County Profile

Appanoose 2004 Annual County Profile, 2004

County Profile

Audubon 2004 Annual County Profile, 2004

County Profile

A TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcoma.

We have recently demonstrated that human pediatric mesenchymal stem cells can be reprogrammed toward a Ewing sarcoma family tumor (ESFT) cancer stem cell (CSC) phenotype by mechanisms that implicate microRNAs (miRNAs). Here, we show that the miRNA profile of ESFT CSCs is shared by embryonic stem cells and CSCs from divergent tumor types. We also provide evidence that the miRNA profile of ESFT CSCs is the result of reversible disruption of TARBP2-dependent miRNA maturation. Restoration of TARBP2 activity and systemic delivery of synthetic forms of either of two of its targets, miRNA-143 or miRNA-145, inhibited ESFT CSC clonogenicity and tumor growth in vivo. Our observations suggest that CSC self-renewal and tumor maintenance may depend on deregulation of TARBP2-dependent miRNA expression.

Benton 2004 Annual County Profile, 2004

County Profile

Black Hawk 2004 Annual County Profile, 2004

County Profile

Boone 2004 Annual County Profile, 2004

County Profile

Bremer 2004 Annual County Profile, 2004

County Profile

Calhoun 2004 Annual County Profile, 2004

County Profile