The novel macrolide-Lincosamide-Streptogramin B resistance gene erm(44) is associated with a prophage in Staphylococcus xylosus.

A novel erythromycin ribosome methylase gene, erm(44), that confers resistance to macrolide, lincosamide, and streptogramin B (MLSB) antibiotics was identified by whole-genome sequencing of the chromosome of Staphylococcus xylosus isolated from bovine mastitis milk. The erm(44) gene is preceded by a regulatory sequence that encodes two leader peptides responsible for the inducible expression of the methylase gene, as demonstrated by cloning in Staphylococcus aureus. The erm(44) gene is located on a 53-kb putative prophage designated ΦJW4341-pro. The 56 predicted open reading frames of ΦJW4341-pro are structurally organized into the five functional modules found in members of the family Siphoviridae. ΦJW4341-pro is site-specifically integrated into the S. xylosus chromosome, where it is flanked by two perfect 19-bp direct repeats, and exhibits the ability to circularize. The presence of erm(44) in three additional S. xylosus strains suggests that this putative prophage has the potential to disseminate MLSB resistance.

Die russische Regierung und die westeuropäischen Juden : zur Schulreform in Rußland 1840-44 ; nach archivalischen Materialien

von Julius Hessen

Die Durchführung des Artikels 44 des Berliner Vertrages in Rumänien und die europäische Diplomatie

von Josef Meisl

Sonate pour le pianoforte et guitarre concertants oeuvre 44

composée par M. Henkel

Augenblicke der Weihe : neun kleine Stücke für Harmonium, Orgel oder Klavier ; op. 44

komponiert von L. Lewandowski

Tôṣe'ôt ḥayyîm : sēfer kôlēl kōl ofnê tefillôt û-taḥanûnîm le-hitpallēl baʿad ha-ḥôlîm we-ham-mētîm ... bi-lšôn ʿivrî û-vi-lšôn aškenazz i

ʿal yedê Yiṣḥāq Ben-Aryê Yôsēf Dōv ...

Sēfer ha-ḥayyîm : ... û-vô mepôrāš kōl dînê śimḥôt ... be-kōl ʿîseqê ham-mētîm ... we-hôsāfnû ... teḥinnôt û-vaqqāšôt raḥamîm be-vêt ha-ḥayyîm ...

Digitalisat der Ausg. Zulṣbak, 1790/91

Sēfer ha-ḥayyîm : ... we-hû tôrā ḥēsed we-emet še-ʿôśîm ʿim ham-mētîm we-ha-ḥayyîm ... we-mā-šem-mitpallēl ha-ḥôlē we-hag-gôsēs...

[Simon Frankfurt]

Ms. Barth. 44 - [Sammelband in 2 Teilen: Konvolut aus Handschrift und Inkunabel]

Vorbesitzer: Friedrich Martorf; Philipp Schurg; Johannes Latomus; Bartholomaeusstift Frankfurt am Main