Regulation of fuel metabolism during exercise in hypopituitarism with growth hormone-deficiency (GHD).

OBJECTIVE Growth hormone (GH) has a strong lipolytic action and its secretion is increased during exercise. Data on fuel metabolism and its hormonal regulation during prolonged exercise in patients with growth hormone deficiency (GHD) is scarce. This study aimed at evaluating the hormonal and metabolic response during aerobic exercise in GHD patients. DESIGN Ten patients with confirmed GHD and 10 healthy control individuals (CI) matched for age, sex, BMI, and waist performed a spiroergometric test to determine exercise capacity (VO2max). Throughout a subsequent 120-minute exercise on an ergometer at 50% of individual VO2max free fatty acids (FFA), glucose, GH, cortisol, catecholamines and insulin were measured. Additionally substrate oxidation assessed by indirect calorimetry was determined at begin and end of exercise. RESULTS Exercise capacity was lower in GHD compared to CI (VO2max 35.5±7.4 vs 41.5±5.5ml/min∗kg, p=0.05). GH area under the curve (AUC-GH), peak-GH and peak-FFA were lower in GHD patients during exercise compared to CI (AUC-GH 100±93.2 vs 908.6±623.7ng∗min/ml, p<0.001; peak-GH 1.5±1.53 vs 12.57±9.36ng/ml, p<0.001, peak-FFA 1.01±0.43 vs 1.51±0.56mmol/l, p=0.036, respectively). There were no significant differences for insulin, cortisol, catecholamines and glucose. Fat oxidation at the end of exercise was higher in CI compared to GHD patients (295.7±73.9 vs 187.82±103.8kcal/h, p=0.025). CONCLUSION A reduced availability of FFA during a 2-hour aerobic exercise and a reduced fat oxidation at the end of exercise may contribute to the decreased exercise capacity in GHD patients. Catecholamines and cortisol do not compensate for the lack of the lipolytic action of GH in patients with GHD.

Precious Corals (Coralliidae) from North-Western Atlantic Seamounts

Two new species belonging to the precious coral genus Corallium were collected during a series of exploratory cruises to the New England and Corner Rise Seamounts in 2003-2005. One red species, Corallium bathyrubrum sp. nov., and one white species, C. bayeri sp. nov., are described. Corallium bathyrubrum is the first red Corallium to be reported from the western Atlantic. An additional species, C. niobe Bayer, 1964 originally described from the Straits of Florida, was also collected and its description augmented.

The Great Moderation and the Relationship between Output Growth and Its Volatility

This study examines the effect of the Great Moderation on the relationship between U.S. output growth and its volatility over the period 1947 to 2006. First, we consider the possible effects of structural change in the volatility process. In so doing, we employ GARCH-M and ARCH-M specifications of the process describing output growth rate and its volatility with and without a one-time structural break in volatility. Second, our data analyses and empirical results suggest no significant relationship between the output growth rate and its volatility, favoring the traditional wisdom of dichotomy in macroeconomics. Moreover, the evidence shows that the time-varying variance falls sharply or even disappears once we incorporate a one-time structural break in the unconditional variance of output starting 1982 or 1984. That is, the integrated GARCH effect proves spurious. Finally, a joint test of a trend change and a one-time shift in the volatility process finds that the one-time shift dominates.

Onkel Moses : Roman

von Schalom Asch. [Übertr. von Siegfried Schmitz]

5. Bericht über den Neureuther Alpenpflanzengarten : erstellt von der Alpenvereinssektion Tegernsee

anonym

Northern Research Farm Summary

Includes Farm and Weather Summary, Information on Experiments in Previous Annual Progress Reports and Research Farm Projects.

Microbiota and Microsatellite genotypes of Pacific oysters stemming from three oyster bed in the Northern Wadden Sea

Background: Studies of oyster microbiomes have revealed that a limited number of microbes, including pathogens, can dominate microbial communities in host tissues such as gills and gut. Much of the bacterial diversity however remains underexplored and unexplained, although environmental conditions and host genetics have been implicated. We used 454 next generation 16S rRNA amplicon sequencing of individually tagged PCR reactions to explore the diversity of bacterial communities in gill tissue of the invasive Pacific oyster Crassostrea gigas stemming from genetically differentiated beds under ambient outdoor conditions and after a multifaceted disturbance treatment imposing stress on the host. Results: While the gill associated microbial communities in oysters were dominated by few abundant taxa (i.e. Sphingomonas, Mycoplasma) the distribution of rare bacterial groups correlated to relatedness between the hosts under ambient conditions. Exposing the host to disturbance broke apart this relationship by removing rare phylotypes thereby reducing overall microbial diversity. Shifts in the microbiome composition in response to stress did not result in a net increase in genera known to contain potentially pathogenic strains. Conclusion: The decrease in microbial diversity and the disassociation between population genetic structure of the hosts and their associated microbiome suggest that disturbance (i.e. stress) may play a significant role for the assembly of the natural microbiome. Such community shifts may in turn also feed back on the course of disease and the occurrence of mass mortality events in oyster populations.

Bajtín, Borges y la resurrección de la rosa

Pensar la propuesta bajtiniana, formulada en las primeras décadas del siglo XX, acerca de las relaciones dialógicas, las entabladas entre el yo y el otro, entre la conciencia propia y la de los demás, entre la palabra propia y la ajena, entre la cultura nacional y las extranjeras, equivale a sumergirnos en uno de los temas o categorías actuales que han despertado las más variadas elaboraciones y discusiones teóricas, desde el espacio de la crítica. Una de las contribuciones más importantes del pensamiento contemporáneo de Mijail Bajtín está relacionada con la teoría del sujeto, cuando, en sus reflexiones acerca del hombre, expresa que lo que define precisamente al ser humano en cuanto tal, es la relación que establece con el otro en el acto creador. Ese otro que, precisamente, es alguien que no soy yo. Así, la alteridad se encuentra en el centro de su pensamiento dialógico. Su filosofía del acto ético parte de las relaciones que el yo entabla con el otro, argumentando que este otro es simplemente alguien que no soy yo, otro inmediato y cotidiano. El otro se convierte así en la primera realidad dada con la que nos encontramos en el mundo, ese mundo cuyo centro es el yo y en el que todos los demás se transforman en otros para mí. Al respecto, propone todo un sistema de relaciones, yo-para-mí, yo-para-otro, otro-para-mí, que se ponen en juego en la interacción cotidiana del sujeto con los otros hombres. Ese juego dialéctico entre “yo soy" y “yo también soy", entre otros, nos lleva a una de las reflexiones significativas del filósofo ruso: es el otro quien me proporciona la primera definición de mí mismo, de mi cuerpo, de mi valor, dada en este caso por la persona que nos recibe por primera vez en el mundo –la madre y su deseo- y desde la posición del otro que posee una visión sobre mi persona y el mundo, al percibir todo aquello que yo no puedo ver desde mi posición única. En suma, partiendo de la premisa expresada por Bajtín acerca de la estructura del diálogo, “siempre está presente la intersección, consonancia o interrupción de las réplicas del diálogo interno de los héroes", este estudio intenta articular, desde un espacio de análisis teórico, cómo el escritor argentino Jorge Luis Borges construye discursivamente al otro/otros en las variaciones del tema en muchas y diversas voces. Los cuentos Veinticinco Agosto 1983, Borges y yo, y La rosa de Paracelso, son los seleccionados para reflexionar y articular el pensamiento dialógico de Mijail Bajtín.