Knowledge management for systems biology a general and visually driven framework applied to translational medicine

Background: To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow predictive hypotheses to be defined. Life science has become a data rich science with information about the behaviour of millions of entities like genes, chemical compounds, diseases, cell types and organs, which are organised in many different databases and/or spread throughout the literature. Existing knowledge such as genotype - phenotype relations or signal transduction pathways must be semantically integrated and dynamically organised into structured networks that are connected with clinical and experimental data. Different approaches to this challenge exist but so far none has proven entirely satisfactory. Results: To address this challenge we previously developed a generic knowledge management framework, BioXM™, which allows the dynamic, graphic generation of domain specific knowledge representation models based on specific objects and their relations supporting annotations and ontologies. Here we demonstrate the utility of BioXM for knowledge management in systems biology as part of the EU FP6 BioBridge project on translational approaches to chronic diseases. From clinical and experimental data, text-mining results and public databases we generate a chronic obstructive pulmonary disease (COPD) knowledge base and demonstrate its use by mining specific molecular networks together with integrated clinical and experimental data. Conclusions: We generate the first semantically integrated COPD specific public knowledge base and find that for the integration of clinical and experimental data with pre-existing knowledge the configuration based set-up enabled by BioXM reduced implementation time and effort for the knowledge base compared to similar systems implemented as classical software development projects. The knowledgebase enables the retrieval of sub-networks including protein-protein interaction, pathway, gene - disease and gene - compound data which are used for subsequent data analysis, modelling and simulation. Pre-structured queries and reports enhance usability; establishing their use in everyday clinical settings requires further simplification with a browser based interface which is currently under development.

Web-based Implementation of Winter Maintenance Decision Support System Using GIS and Remote Sensing, May 2005

Winter maintenance, particularly snow removal and the stress of snow removal materials on public structures, is an enormous budgetary burden on municipalities and nongovernmental maintenance organizations in cold climates. Lately, geospatial technologies such as remote sensing, geographic information systems (GIS), and decision support tools are roviding a valuable tool for planning snow removal operations. A few researchers recently used geospatial technologies to develop winter maintenance tools. However, most of these winter maintenance tools, while having the potential to address some of these information needs, are not typically placed in the hands of planners and other interested stakeholders. Most tools are not constructed with a nontechnical user in mind and lack an easyto-use, easily understood interface. A major goal of this project was to implement a web-based Winter Maintenance Decision Support System (WMDSS) that enhances the capacity of stakeholders (city/county planners, resource managers, transportation personnel, citizens, and policy makers) to evaluate different procedures for managing snow removal assets optimally. This was accomplished by integrating geospatial analytical techniques (GIS and remote sensing), the existing snow removal asset management system, and webbased spatial decision support systems. The web-based system was implemented using the ESRI ArcIMS ActiveX Connector and related web technologies, such as Active Server Pages, JavaScript, HTML, and XML. The expert knowledge on snow removal procedures is gathered and integrated into the system in the form of encoded business rules using Visual Rule Studio. The system developed not only manages the resources but also provides expert advice to assist complex decision making, such as routing, optimal resource allocation, and monitoring live weather information. This system was developed in collaboration with Black Hawk County, IA, the city of Columbia, MO, and the Iowa Department of transportation. This product was also demonstrated for these agencies to improve the usability and applicability of the system.

Implementation and evaluation of an internet health site for adolescents in Switzerland.

Ciao is a website specifically designed for young people and focuses mainly on health issues. This report presents the process of setting up the site and a first evaluation undertaken by using two self-administered questionnaires administered via the website itself. It suggests that it is possible to provide young people with authoritative health information and to facilitate their access to counseling and health care facilities by having young people use such a website.

A multicase study for the evaluation of a pattern-based visual design process for collaborative learning

Collage is a pattern-based visual design authoring tool for the creation of collaborative learning scripts computationally modelled with IMS Learning Design (LD). The pattern-based visual approach aims to provide teachers with design ideas that are based on broadly accepted practices. Besides, it seeks hiding the LD notation so that teachers can easily create their own designs. The use of visual representations supports both the understanding of the design ideas and the usability of the authoring tool. This paper presents a multicase study comprising three different cases that evaluate the approach from different perspectives. The first case includes workshops where teachers use Collage. A second case implies the design of a scenario proposed by a third-party using related approaches. The third case analyzes a situation where students follow a design created with Collage. The cross-case analysis provides a global understanding of the possibilities and limitations of the pattern-based visual design approach.

Welcoming New Iowans; A Guide for Christians and Churches, 2002

Immigrant and refugee newcomers have an important role in Iowa. These newcomers have revitalized many Iowa communities, workplaces and faith-based institutions. The arrival of immigrants and refugees poses challenges as well as rewards; understanding and addressing these issues is vital to welcoming and accommodating new Iowans and assuring their part in the long-term economic and social health of our state. This handbook represents a unique collaboration between the University of Northern Iowa (UNI) and Ecumenical Ministries of Iowa (EMI). The goal of this collaboration is to create a guidebook for Iowans to learn more about Iowa’s growing immigrant and refugee population and discover ways to welcome these newcomers and accommodate them in our communities and churches. The unique nature of this joint publication between a public university and Christian churches acknowledges that both institutions have a stake in accommodating immigrants in Iowa. UNI and all institutions of higher education need to support population growth to assure future enrollments. Churches and many other community institutions need immigrants and other newcomers to help maintain their viability. Universities and churches also need healthy local economies. Newcomers can provide much needed skills and labor to make this happen. In short, His collaboration recognizes that making immigration in Iowa work has important long-term implications for us all. This book was written and compiled by two university faculty members, but it is not an official university endorsement of Christianity as the only religion practiced and accepted by Iowans, and no university funds were used to print or distribute this handbook. This handbook is written for Iowa’s Christian community and is based on the Biblical mandate to welcome newcomers, but we acknowledge Iowa’s other religious groups and their role in accommodating newcomers as well. We readily acknowledge that other faith-based organizations also welcome newcomers and have a stake in making immigration a positive experience. In order to accommodate the perspectives and needs of these groups, the UNI New Iowans Program is planning to develop similar handbooks for Iowa’s Jewish and Muslim communities. This handbook includes a number of resource lists for individuals, newcomers, churches and others. Of course, as soon as these lists are printed, they may become out-of-date. In order to obtain the most up-to-date information, please visit the UNI New Iowans Web site: www.bcs.uni.edu/idm/newiowans/ The UNI New Iowans website also makes this handbook available in a PDF format.

Towards a User-Friendly Platform for Building Language Resources based on Web Services

This paper presents the platform developed in the PANACEA project, a distributed factory that automates the stages involved in the acquisition, production, updating and maintenance of Language Resources required by Machine Translation and other Language Technologies. We adopt a set of tools that have been successfully used in the Bioinformatics field, they are adapted to the needs of our field and used to deploy web services, which can be combined to build more complex processing chains (workflows). This paper describes the platform and its different components (web services, registry, workflows, social network and interoperability). We demonstrate the scalability of the platform by carrying out a set of massive data experiments. Finally, a validation of the platform across a set of required criteria proves its usability for different types of users (non-technical users and providers).

Identity formation in social networks websites: facebook and the interaction between young individuals in the cases of Slovenia and Catalonia

This paper lays down some theoretical framework for further research to be made on the subject of how identity of young Slovenian and Catalan users is forming within the social networking website Facebook. The author pursues his interest based on observation of how communicationand thus interaction between users is changing and how this is reflected in everyday practices. In so doing he tries to identify the connections between the individual, society and technology, asthese are more and more interwoven, and we cannot think one without the other in thecontemporary globalised world.

Hotusa hotels

Hotusa nace en 1977 fruto de la iniciativa de un grupo de hoteleros de Barcelona (España) que, ante la pujanza de las nuevas cadenas hoteleras, deciden unir sus fuerzas creando una organización que les preste servicios de comercialización de forma conjunta. Hoy en día Hotusa cuenta con más de 2.500 hoteles en 48 países de cuatro continentes y se configura como uno de los principales consorcios hoteleros a nivel mundial y el primero a nivel europeo. La organización está formada, entre otras, por las cadenas de hoteles independientes Hotusa Hotels y Elysées West Hotels; el representante hotelero Keytel; el tour operador Restel; la website de gestión y reserva on-line Hotelius.com, la compañía tecnológica IGM Web; la cadena Eurostars Hotels. El objetivo de Hotusa es el de dotar a hoteles independientes y pequeños grupos, de todas aquellas herramientas que puedan ayudarles a competir en igualdad de condiciones con las grandes cadenas hoteleras a nivel internacional. Comercialización, distribución, representación, tecnología, sistemas de calidad y aprovisionamientos son los puntos fuertes de la compañía, sobre los que gira la actividad tradicional. La segmentación en diferentes marcas y, en consecuencia, la adaptación a ellas de los servicios, constituye el gran reto de futuro de la organización. La sede central se encuentra en Barcelona (España), si bien cuentan con oficinas en Roma, Paris, Londres, Viena, Lisboa y Buenos Aires. En 2008 recibió el Premio Príncipe Felipe a la Excelencia Turística, otorgado por el Ministerio de Industria, Turismo y Comercio de España como reconocimiento a su contribución al incremento de la competitividad de la industria turística española así como a la consolidación de su posición en el mercado turístico internacional.

Testaus käytettävyyden tutkimisessa : tapaus Mesta-portaali

Opinnäytetyömme koostuu Helsingin ammattikorkeakoulu Stadian Mesta-portaalille vuoden 2006 aikana tehdyn käytettävyystutkimuksen raportista sekä sen toteuttamista ja tuloksia esittelevästä kirjallisesta osasta. Sekä käytettävyystestaus että opinnäytetyö on toteutettu parityönä. Mesta on Stadian verkkopalvelujen portaali, joka lanseerattiin joulukuussa 2006 Stadian opettajien, opiskelijoiden ja henkilökunnan käyttöön. Mesta sisältää Stadian tärkeimmät tietojärjestelmät ja verkkopalvelut, kuten sähköpostin ja tilanvarausjärjestelmän, sekä tarjoaa uusia palveluja. Näitä ovat esimerkiksi työtilat ja keskustelualueet. Käytettävyys on tuotteen ominaisuus, joka määrittelee sen, kuinka sujuvaa, tehokasta ja opittavaa sen käyttö on. Käytettävyystutkimuksilla voidaan selvittää, kuinka hyvin käytettävyyden tavoitteissa on onnistuttu. Käytettävyydellä on yhä suurempi merkitys verkkopalveluissa ja erilaisissa laitteissa, sillä ne ovat tulleet erittäin laajaan käyttöön ja niiltä osataan odottaa käyttömukavuutta. Vaikeasti käytettävä tuote menettää merkittävän kilpailuedun. Mestalle päätettiin tehdä käytettävyystestaukset, sillä käytettävyydeltään onnistuneen portaalin ajateltiin houkuttelevan käyttäjiä. Testauksen tavoitteena oli antaa järjestelmän kehittäjille informaatiota, jonka avulla he voisivat parantaa portaalin käytettävyyttä. Haasteena oli portaalin laaja käyttäjäkunta, jolla on hyvin erilaista osaamista tietokoneiden ja verkkopalvelujen käyttämisestä. Tästä huolimatta portaalin tuli palvella heitä tasapuolisesti. Testaukset toteutettiin seitsemällä testihenkilöllä siten, että he suorittivat palvelussa heille annettuja tehtäviä samalla kun testitilannetta tarkkailtiin sekä paikan päällä että videoiden. Tehtävien avulla etsittiin portaalin käyttöliittymän ongelmakohtia ja löydetyt ongelmat kirjoitettiin testausraportiin kehitysehdotuksiksi. Näitä ehdotuksia syntyi 55 kappaletta ja niistä suurin osa otettiin käyttöön Mesta-portaalissa.

Käyttäjäystävällisen mobiilipalvelun suunnittelu : WAP-sivuston rakentaminen visuaalisen ja käyttöliittymäsuunnittelun keinoin

Opinnäytteeni käsittelee mobiilipalveluiden sekä visuaalista että käyttöliittymäsuunnittelua. Lähden liikkeelle siitä olettamuksesta, että näiden osa-alueiden suunnitteluun kannattaa panostaa. Totean myös, että näin ei kuitenkaan vielä nykyään tehdä. Käsittelen mobiilipalveluja yleisemmällä tasolla, mutta keskityn erityisesti WAP-pohjaisiin palveluihin. Samat periaatteet ja vinkit soveltuvat kuitenkin myös muilla alustoilla toimivien palveluiden suunnitteluun, ja koska minulla on kokemusta myös näistä, olen tuonut tätäkin puolta esiin. Työssäni puhutaan visuaalisesta suunnittelusta ja käytettävyydestä yleisellä tasolla, mutta se toimii samalla eräänlaisena ohjekirjana suunnittelijalle. Uskon, että vielä toistaiseksi yritykset siirtyvät WAPiin pitkälti samalla sisällöllä ja rakenteella kuin web-palvelussaan, ja esittelen työssäni syitä sille, miksi tämä menetelmä on huono. Työhöni kokoamani pikamanuaali kokoaa tärkeimmät käytännön vinkit, joiden avulla voidaan tarvittaessa nopeallakin aikataululla suunnitella käyttäjäystävällinen WAP-palvelu. Kiinnostus aiheeseen nousi omista kokemuksistani työelämässä, ja kirjatiedon lisäksi tärkeänä lähteenä on toiminut oma kokemusmaailmani ja yrityksen ja erehdyksen kautta opitut taidot. Uskon että myös nämä tuovat hyvän lisän oppaaseen. Käsittelen ensin matkaviestinalan yleistä kehitystä ja esittelen syitä sille, miksi mobiilipalveluiden suunnitteluun kannattaa panostaa. Käyn sitten läpi sellaisia mobiililaitteiden erityisominaisuuksia, jotka asettavat työlle omat rajoituksensa. Lopuksi listaan tärkeimmät huomioitavat seikat ja annan käytännön vinkkejä suunnitteluprosessiin.

Evaluation of a Bridge Constructed using High Performance Steel, May 2006

Of the approximately 25,000 bridges in Iowa, 28% are classified as structurally deficient, functionally obsolete, or both. Because many Iowa bridges require repair or replacement with a relatively limited funding base, there is a need to develop new bridge materials that may lead to longer life spans and reduced life-cycle costs. In addition, new and effective methods for determining the condition of structures are needed to identify when the useful life has expired or other maintenance is needed. Due to its unique alloy blend, high-performance steel (HPS) has been shown to have improved weldability, weathering capabilities, and fracture toughness than conventional structural steels. Since the development of HPS in the mid-1990s, numerous bridges using HPS girders have been constructed, and many have been economically built. The East 12th Street Bridge, which replaced a deteriorated box girder bridge, is Iowa’s first bridge constructed using HPS girders. The new structure is a two-span bridge that crosses I-235 in Des Moines, Iowa, providing one lane of traffic in each direction. A remote, continuous, fiber-optic based structural health monitoring (SHM) system for the bridge was developed using off-the-shelf technologies. In the system, sensors strategically located on the bridge collect raw strain data and then transfer the data via wireless communication to a gateway system at a nearby secure facility. The data are integrated and converted to text files before being uploaded automatically to a website that provides live strain data and a live video stream. A data storage/processing system at the Bridge Engineering Center in Ames, Iowa, permanently stores and processes the data files. Several processes are performed to check the overall system’s operation, eliminate temperature effects from the complete strain record, compute the global behavior of the bridge, and count strain cycles at the various sensor locations.

Consumer Satisfaction with Websites of Banks - The Moderating Effect of Consumer Technology Attractiveness

The websites are becoming the firms’ first contact interface with their clients. Hence, understanding customers’ online attitudes and behaviors have been capturing increased research attention. The extant research has pointed customers’ satisfaction with the websites as the main reason for customers’ online behaviors. This research has used mostly variables related to the characteristics of the websites as the predictors of customers’ website satisfaction. However, recent research shows that groups of individuals displaying distinctive characteristics react differently to the same context. Therefore, behavior may be considerably different among groups of customers. In this study, we develop a conceptual model of the influence of individual characteristics on the traditional website quality – website satisfaction relationship. We propose a model based on the construct of consumer technology attractiveness (CTA) to represent the genuine positive propensity of individuals toward technology. We further test the moderating effect of this construct on the commonly used predictors of customer’s website satisfaction using Hierarchical Multiple Regression. The empirical study was based on websites of banks operating in Portuguese market. The commercial banking industry is one of the Portuguese industries that better uses the Internet to establish relationships with clients. Data were collected through an online website satisfaction survey, participated by the lecturers and postgraduate students from four Portuguese Universities and Polytechnic Institutes. Our final sample comprised 276 valid questionnaires. Our study permits to conclude that the most commonly used antecedents of website overall satisfaction are still relevant for analyzing consumer’s satisfaction with the banks websites. We also conclude that CTA has a significant moderating effect on almost all customers’ website satisfaction variables used in the study. This study contributes to highlight the theoretical importance and significant influence of consumers’ personal characteristics on their online behavior. Moreover, for the practitioners, a better understanding of these individual characteristics will assist them in developing customized websites that will meet customers’ expectations. O estudo dos comportamentos dos consumidores em ambientes online tem vindo a ter um crescente interesse, uma vez que os websites estão a transformar-se num importante ponto de contacto entre as empresas e os seus clientes. A satisfação dos clientes com os websites tem sido apontada pela Literatura como o principal condicionante dos comportamentos online dos consumidores. No entanto, a investigação científica tem conseguido provar que grupos de indivíduos com características distintas reagem de forma diferente quando submetidos a contextos idênticos, o que poderá levar a diferenças significativas no comportamento online de consumidores pertencentes a diferentes grupos. Neste estudo desenvolvemos um modelo conceptual que reflecte a influência de características individuais na relação entre a qualidade e a satisfação com os websites. Propomos um modelo assente na atractividade tecnológica do consumidor (CTA), que representa a propensão genuína que os indivíduos possuem em relação à tecnologia. Testamos o efeito moderador deste conceito sobre as variáveis mais utilizadas nos estudos sobre a satisfação dos consumidores com os websites, utilizando a Regressão Múltipla Hierárquica. O estudo empírico baseou-se nos websites dos bancos que operam no mercado português, uma vez que este sector é um dos que melhor utiliza a Internet na sua relação com os clientes. Os dados foram recolhidos através de um questionário sobre satisfação com os websites, colocado online e dirigido a docentes e estudantes de programas de pós-graduações, mestrados e doutoramentos de quatro universidades e instituto politécnico portugueses, tendo resultado numa amostra final de 276 questionários validados estatisticamente. Este estudo permitiu concluir que as variáveis que são mais utilizadas como antecedentes da satisfação dos consumidores com os websites, continuam a ser igualmente válidas para a análise dos websites dos bancos. Também concluímos que a CTA tem efeitos moderadores significativos na grande maioria das variáveis utilizadas neste estudo. Assim, conseguimos realçar a importância teórica das características pessoais dos consumidores no seu comportamento online. Para os gestores, uma melhor compreensão destas características individuais permitir-lhes-á desenvolver websites customizados que irão satisfazer as expectativas dos seus clientes.

Hospitalizations leading causes for maternal disorders

Presenting the rates of obstetric admissions of women living in Paraná in 2010.Method: A descriptive study in which the admission information of the hospital system of the Unified Health System was analyzed. Data from women aged between 10 to 49 years available on the DATASUS website were analyzed, using percentage and according to primary diagnosis, age and Regional Health area.Results: The Rate of Obstetric Complications (RtOC) was 38%, increasing with the age of women. Complications of labor and delivery (10.5%), and pregnancy with abortive outcome (9.1%) were the diagnoses with highest RtOC. The RtOC ranged between 8.4% in Telêmaco Borba, until 62.6% in Ponta Grossa.Conclusion: The healthcare team should monitor the rates of admissions for obstetric complications as these indicate the quality of health care of women, mainly focused on labor, delivery and women of older age.


Adesão de Cabo Verde à Organização Mundial do Comércio - Problemas, Desafios e Perspectivas

A dinâmica de desenvolvimento de Cabo Verde vem sendo uma constante, com ganhos significativos para o país, como atestam a recente adesão à Organização Mundial do Comércio, a graduação a País de Rendimento Médio e a Parceria Especial com a União Europeia. No dia 23 de Julho de 2008, Cabo Verde tornou-se no 153º Estado membro da Organização Mundial do Comércio, sendo que nesta conquista foi o primeiro país Africano e o terceiro País Menos Avançado a conseguir este importante marco via negocial. As vantagens advenientes desta adesão são muitas, sendo de destacar a maior confiança dos investidores no país ao propiciar-se a expansão do mercado e a realização de negócios num ambiente mais seguro e estável, e ainda a possibilidade de melhoria da qualidade de prestação de serviços, uma vez que tudo passou a ser norteado por padrões e regras do comércio internacional. Este trabalho foi elaborado com base em pesquisa bibliográfica e exploratória necessária à construção de um referencial teórico sobre o assunto em questão, tendo como base artigos, livros, revistas e consultas em websites. Finalizando, para avaliação, apresentamos uma componente prática com base num questionário aplicado ao tecido empresarial, com perguntas abertas e de múltipla escolha, onde os inquiridos puderam fazer a sua apreciação relativa ao processo de adesão, e às expectativas advenientes. Os resultados obtidos no final do trabalho mostraram de forma clara e inequívoca a necessidade de Cabo Verde se reorganizar, reforçar o sector privado e a competitividade das empresas, através de, designadamente: melhoria do ambiente fiscal das empresas, fomento e apoio às pequenas e médias empresas. Outrossim, há que dar seguimento as reformas no sector comercial, capacitando e formando quadros nacionais uma vez que estes desempenham um papel essencial no crescimento económico do país e permitem dar maior previsibilidade aos investidores, sendo este último um dos pilares decisivos no requisito do investimento externo. The dynamics of the development of Cape Verde is becoming a constant, with significant gains to the country, as attests the recent adhesion to the World Trade Organization, the graduation to Country of Medium Revenue, as well as the Special Partnership with the European Union. On July 23, 2008, Cape Verde became the 153rd State member of the World Trade Organization, and in this conquest it was the first African country and the third Less Advanced Country to get this mark through negotiable way. The advantages proceeding from this adhesion are many, highlighting the investors' largest trust in the country when propitiating the expansion of the market and the accomplishment of business in a safer and stable atmosphere, and still the possibility of improvement of the quality of installment of services, once everything started being guided by patterns and rules of the international trade. This work was elaborated based on bibliographical and exploratory researches necessary to the construction of the theoretical referential about the subject in question, based on articles, books, magazines and website researches. Concluding, for evaluation, we presented a practical component based on a questionnaire applied to the managerial stuff, with open and multiple choice questions, where the inquired could make his appreciation related to the adhesion process, and the proceeding expectations. The results obtained at the end of the work, showed in a clear way the need of Cape Verde to organize, to reinforce the private sector and the competitiveness of the companies, through, namely: the improvement of the fiscal atmosphere of the companies, fomentation and support of the small and medium companies. Meanwhile, it is important to continue the reforms in the commercial sector, qualifying and forming national staff once they play an essential part in the economic growth of the country and allow giving a larger previsibility to the investors, being this last one, one of the decisive pillars in the requirement of the external investment.

Comércio Electrónico: Reservas Online da Agência Krioula

O trabalho que ora se apresenta, Comércio Electrónico: Reservas Online da Agência Aliança Krioula”, é um trabalho de final do curso, para obtenção de grau de Licenciatura em Tecnologias de Informação e Comunicação. O objectivo deste trabalho é a elaboração de um site de Comércio Electrónico para a agência de viagem Aliança Krioula, de forma a possibilitar as pessoas efectuarem as suas Reservas Online.Para a elaboração do mesmo, foi utilizado a ferramenta Joomla, visto que é uma ferramenta gratuita e muito poderosa, que serve para conceber sites de forma rápida e eficiente. Também o trabalho tem como principal propósito, conceptualizar alguns termos relacionados com o Comercio Electrónico. O projecto procura mostrar a importância do Comércio Electrónico nas sociedades modernas. A realização deste trabalho possibilitou a chegada de conclusões importantes sobre vários aspectos de Comércio Electrónico e Gestão de Conteúdo, mais concretamente a ferramenta Joomla que serviu de suporte para o Website.