1000 resultados para potenciais evocados auditivos de tronco encefálico


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Pós-graduação em Medicina Veterinária - FCAV

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Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Agronomia (Ciência do Solo) - FCAV

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Mammary tumors are the most frequent cancers in dogs, representing about 50% of tumors, and have a higher incidence in females of middle aged and elderly. These tumors have been used as a model for breast cancer in women due to several common characteristics such as histological and immunohistochemical similarities. In the last decade, studies based on molecular profiles of breast cancer, made possible the identification of some neoplastic cells with characteristics of stem cells - cancer stem cells (CSC). One of the putative molecules of CSCs is CD44. Recent studies have established a crucial link between the epithelial-mesenchymal transition (EMT) and the acquisition of molecular and functional properties of stem cells. For that reason we analyzed the expression of proteins CD44, Cytokeratins AE1/AE3 and Vimentin, in dogs mammary tumors, to investigate the potencial for CSC markers, and its relation with the EMT using immunohistochemistry in paraffin embedded tissues making use of techniques such as Tissue MicroArrays (TMA). Immunostaining of cytokeratin had no significant difference between benign and malignant tumors (p ≥ 0,05), being more intense in malignant tumors. However vimentina showed higher staining intensity in benign tumors, but with no significant difference (p ≤ 0,05). The expression of CD44 was higher in malignant tumors that have greater proliferative and metastatic potencial, however its relation with EMT was not detected in the analyzed tumors. The techniques applied for the TMAs were efficient and can be used in routine and later researches.

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Introduction: A variety of hypotheses have been proposed to explain the association between temporomandibular disorders and hearing symptoms, including the many anatomical and/or neurological ways, as of a muscle or joint dysfunction, can cause such symptoms. Objective: The purpose of this study is to discuss, through a systematic review of literature, the interrelation between hearing symptoms and temporomandibular disorders. Material and Methods: We consulted the Medline/PubMed, ISI and Scielo in the period 1918 to 2008. The terms related to the research were: “temporomandibular disorders”, “signs and symptoms of temporomandibular disorders”, “otologic symptoms” and “aural symptoms”, where 19 papers were included using the pre-selected criteria for the manufacture of a meta-analysis. Results: According to the findings, the hearing symptoms most often associated with temporomandibular disorders were otalgia and tinnitus, followed by vertigo and hearing loss, respectively. Conclusions: It’s clear the correlation between hearing symptoms and temporomandibular disorders, however there is a need clinical and scientific research more complex to prove the specific cause-effect relationships between them.

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Introdução: As exigências nutricionais para o paciente transplantado são conhecidas, mas há poucas evidências sobre o consumo alimentar e o seu efeito no estado nutricional. O objetivo deste estudo é avaliar o efeito do transplante de células-tronco hematopoéticas (TCTH) no estado nutricional de pacientes orientados e monitorados quanto ao consumo alimentar durante os primeiros 100 dias do procedimento. Método: Participaram do estudos 27 indivíduos que realizaram TCTH, com idade entre 20 e 60 anos, 13 mulheres e 14 homens, índice de massa corporal médio de 27+/- 5kg/m². Os pacientes receberam orientações nutricionais individualizadas quanto ao consumo de alimentos. Nos momentos pré-TCTH, D+30, D_60 e D+100 (D+n = dias decorridos do TCTH) foram monitorados o consumo de alimentos, a partir de recordatório do consumo de 24 horas e o estado nutricional a partir dos indicadores antropométricos. Resultados: Após 100 dias do transplante, foi constatado que os 27 indivíduos analisados mantiveram estáveis o consumo alimentar e o estado nutricional. Conclusão: A orientação nutricional proporcionou a preservação do estado nutricional após o TCTH, a qual se deu à custa de incremento no consumo de energia e nutrientes oriundos de suplementos alimentares e também de alimentos não tão saudáveis.