Suomen valkoinen sotilasarkkitehtuuri 1926-1939

Summary: "White" military architecture in Finland, 1926-1939

Keskustajääkäri Aarne Sihvo : näkökulma aseellisen voiman ja yhteiskunnan vuorovaikutukseen itsenäistymisen murroksesta paasikiviläiseen toiseen tasavaltaan

Summary: Middle-of-the-roader : General Aarne Sihvo (1889-1963) and the interaction between the Finnish armed forces and democracy

Nuoren Apollon syöksykierre : sivistyneistö ja kansallisen ideologian murroksia

Päivi Molarius

Recueil de pièces sur le comput.

Contient : 1 Calendrier en français ; 2 Des «.XII. Singnes dou ciel » ; 3 « Table de la lune » ; 4 « Table des.VII. plannettes » ; 5 « Numerus et inspiratio Pitagore » ; 6 « Questiones » prognosticorum ; 7 De spheris ; 8 « Liber de rota Fortune » ; 9 Détermination des « hores par le quadrant » ; 10 « Les.XII. Venredis que li douse apostre junnerent »

Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.

Through a rational design approach, we generated a panel of HLA-A*0201/NY-ESO-1(157-165)-specific T cell receptors (TCR) with increasing affinities of up to 150-fold from the wild-type TCR. Using these TCR variants which extend just beyond the natural affinity range, along with an extreme supraphysiologic one having 1400-fold enhanced affinity, and a low-binding one, we sought to determine the effect of TCR binding properties along with cognate peptide concentration on CD8(+) T cell responsiveness. Major histocompatibility complexes (MHC) expressed on the surface of various antigen presenting cells were peptide-pulsed and used to stimulate human CD8(+) T cells expressing the different TCR via lentiviral transduction. At intermediate peptide concentration we measured maximum cytokine/chemokine secretion, cytotoxicity, and Ca(2+) flux for CD8(+) T cells expressing TCR within a dissociation constant (K(D)) range of ∼1-5 μM. Under these same conditions there was a gradual attenuation in activity for supraphysiologic affinity TCR with K(D) < ∼1 μM, irrespective of CD8 co-engagement and of half-life (t(1/2) = ln 2/k(off)) values. With increased peptide concentration, however, the activity levels of CD8(+) T cells expressing supraphysiologic affinity TCR were gradually restored. Together our data support the productive hit rate model of T cell activation arguing that it is not the absolute number of TCR/pMHC complexes formed at equilibrium, but rather their productive turnover, that controls levels of biological activity. Our findings have important implications for various immunotherapies under development such as adoptive cell transfer of TCR-engineered CD8(+) T cells, as well as for peptide vaccination strategies.

Investigación de crustáceos de profundidad en la zona de Pisco - Callao

Entre el 14 y 27 de diciembre del 2005, se efectuó el crucero de investigación de crustáceos de profundidad a bordo del BIC Imarpe VI. Se realizaron 14 lances entre 12°S y 15°S y en dos estratos de profundidad (A: 700-1000 m, B: 1000-1400 m). Las operaciones de pesca se realizaron durante el día. En los experimentos de captura fueron utilizados diferentes tipos de mallas, carnadas y color de la boca de entrada de la nasa. Se registraron 4 especies: Paralomis longipes, Lithodes wiracocha, Lithodes panamensis y Lopholithodes diomedeae, siendo la de mayor incidencia Paralomis longipes. Se capturaron un total de 327 ejemplares con 305 kg. Los mayores rendimientos se registraron en el estrato B en 14°S y se encontraron los mayores tamaños de P. longipes, sin embargo, Lithodes panamensis alcanzó mayores tamaños que P. longipes. La proporción sexual fue favorable a machos. Las hembras de P. longipes en su mayoría portaban huevos. Se observó y estimó la incidencia de parásitos rizocefalos, epibiontes y la frecuencia de muda.

Suuresta suvusta pieneen perheeseen : itäsuomalainen perhe 1700-luvulla

Summary: From joint family to nuclear family

Kauppias, kaupunki, kruunu : Turun porvariyhteisö ja talouden organisaatio varhaiskeskiajalta 1570-luvulle

Summary: The merchant, the town and the crown : the burgher community of Turku and economic organization from the early Middle Ages to the 1570's

Taannehtiva kansallisbibliografia ja taannehtiva kansalliskirjallisuus

Rainer Knapas

Français 1544

Contient : 1° « La Vie des enciens Peres » ; 2° « La Vie de la sainte Ame » ; 3° « La tres noble et tres merveilleuse Histoire du purgatoire saint Patrice »

Français 1544

Contient : 1° « La Vie des enciens Peres » ; 2° « La Vie de la sainte Ame » ; 3° « La tres noble et tres merveilleuse Histoire du purgatoire saint Patrice »