Executive Order Number Thirty One, June 29, 1987

Establish gift reporting requirements for the Executive Department of State Government.

Executive Order Number Thirty Two, July 7, 1987

Create the Governor's Alliance on Substance Abuse within the Department of Public Health.

Executive Order Number Thirty Three, August 21, 1987

Continue the TIM Council.

Executive Order Number Thirty Four, July 22, 1988

Provisions of Equal Empolyment Opportunity and Affirmation Action in State government enforced through the Iowa Department of Management.

Executive Order Number Thirty Five, September 27, 1988

Creates the Iowa Commission on Foreign Language Studies and International Education

Executive Order Number Thirty Six, Febraury 13, 1989

Iowa state government shall be models for developing and implementing comprehensive programs for waste reduction, recycling, and the use of recycled products.

Executive Order Number Thirty Seven, Febraury 13, 1989

State government shall be models for developing and implementing comprehensive programs for waste reduction, recycling, and the use of recycled products.

Executive Order Number Thirty Eight, March 17, 1989

In complaiance with the Drug Free Workplace Act of 1988, State of iowa is obliged to provide a drug and alcohol free environment including disciplinary action.

Executive Order Number Thirty Nine, September 12, 1989

Forms State hazard mitigation team, chaired by Department of Public Defense, Disaster Services Division, to determine capabilitites of State agencies, provide assistance, improve preparedness, response, and recovery from disasters.

Executive Order Number Forty, November 1, 1990

The Governor's Alliance on Substance Abuse is the designed agency to receive Drug Control& System Improvement Grant Program funding.

Executive Order Number Forty One, November 6, 1990

Empowers the Governor to accept retrocession of Federal jurisdiction if offered by appropriate federal authorities.

Executive Order Number Forty Two, July 1991

Invokes across-the-board budget reductions as determinded by the Governor.

Executive Order Number Forty Three, April 30, 1992

Invokes further budget cuts as determinded by the Governor.

Executive Order Number Forty Four, April 30, 1992

Rescinds Executive Order #46 and recommits efforts of the Executive branch and all department directors, member of governing boards and commissions, and other public officers affirmative action, discriminatory harrassment prevention, and cultural diversity.

Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.

DP1, a dimerization partner protein of the transcription factor E2F, is known to inhibit Wnt/β-catenin signalling along with E2F, although the function of DP1 itself was not well characterized. Here, we present a novel dual regulatory mechanism of Wnt/β-catenin signalling by DP1 independent from E2F. DP1 negatively regulates Wnt/β-catenin signalling by inhibiting Dvl-Axin interaction and by enhancing poly-ubiquitination of β-catenin. In contrast, DP1 positively modulates the signalling upon Wnt stimulation, via increasing cytosolic β-catenin and antagonizing the kinase activity of NLK. In Xenopus embryos, DP1 exerts both positive and negative roles in Wnt/β-catenin signalling during anteroposterior neural patterning. From subcellular localization analyses, we suggest that the dual roles of DP1 in Wnt/β-catenin signalling are endowed by differential nucleocytoplasmic localizations. We propose that these dual functions of DP1 can promote and stabilize biphasic Wnt-on and Wnt-off states in response to a gradual gradient of Wnt/β-catenin signalling to determine differential cell fates.