Sunshine Advisory, November, 2003

A Bulletin on Iowa Open Meetings and Public Records Laws by Attorney General Tom Miller

Sunshine Advisory, December 2003

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Sunshine Advisory, July 2003

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Internal test sets studies in a group of antimalarials

Topological indices have been applied to build QSAR models for a set of 20 antimalarial cyclic peroxy cetals. In order to evaluate the reliability of the proposed linear models leave-n-out and Internal Test Sets (ITS) approaches have been considered. The proposed procedure resulted in a robust and consensued prediction equation and here it is shown why it is superior to the employed standard cross-validation algorithms involving multilinear regression models

Sunshine Advisory, February 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Sunshine Advisory, May 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Sunshine Advisory, March 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Sunshine Advisory, July 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Sunshine Advisory, June 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.

Invasive fungal diseases (IFDs) have become major causes of morbidity and mortality among highly immunocompromised patients. Authoritative consensus criteria to diagnose IFD have been useful in establishing eligibility criteria for antifungal trials. There is an important need for generation of consensus definitions of outcomes of IFD that will form a standard for evaluating treatment success and failure in clinical trials. Therefore, an expert international panel consisting of the Mycoses Study Group and the European Organization for Research and Treatment of Cancer was convened to propose guidelines for assessing treatment responses in clinical trials of IFDs and for defining study outcomes. Major fungal diseases that are discussed include invasive disease due to Candida species, Aspergillus species and other molds, Cryptococcus neoformans, Histoplasma capsulatum, and Coccidioides immitis. We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge.

Sunshine Advisory, August 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Red blood cell microparticles and blood group antigens: an analysis by flow cytometry.

BACKGROUND: The storage of blood induces the formation of erythrocytes-derived microparticles. Their pathogenic role in blood transfusion is not known so far, especially the risk to trigger alloantibody production in the recipient. This work aims to study the expression of clinically significant blood group antigens on the surface of red blood cells microparticles. MATERIAL AND METHODS: Red blood cells contained in erythrocyte concentrates were stained with specific antibodies directed against blood group antigens and routinely used in immunohematology practice. After inducing erythrocytes vesiculation with calcium ionophore, the presence of blood group antigens was analysed by flow cytometry. RESULTS: The expression of several blood group antigens from the RH, KEL, JK, FY, MNS, LE and LU systems was detected on erythrocyte microparticles. The presence of M (MNS1), N (MNS2) and s (MNS4) antigens could not be demonstrated by flow cytometry, despite that glycophorin A and B were identified on microparticles using anti-CD235a and anti-MNS3. DISCUSSION: We conclude that blood group antigens are localized on erythrocytes-derived microparticles and probably keep their immunogenicity because of their capacity to bind specific antibody. Selective segregation process during vesiculation or their ability to elicit an immune response in vivo has to be tested by further studies.

Sunshine Advisory, September 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Sunshine Advisory, October 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller

Sunshine Advisory, November 2004

A Bulletin on Iowa Open Meetings and Public Records Laws By Attorney General Tom Miller