El Mole: N��mero 1 - D��a 3 de noviembre de 1840

Microfilme. Valencia: BV, ca. 1990

CONFLITO RELIGIOSO, MART��RIO E EXALTA����O VISION��RIA: O CASO DE ESTEV��O EM ATOS 6,1-8,3

Nesta disserta����o nos propomos a fazer uma leitura da narrativa de Atos dos Ap��stolos 6,1-8,3, considerando-a nos moldes de uma antiga tradi����o de mart��rio. Os Helenistas entram em conflito com os Hebreus, Estev��o entra em atrito com os judeus da di��spora que se re��nem nas sinagogas, e �� levado perante o Sin��drio e executado. O motivo de sua execu����o �� a cr��tica �� Lei e ao Templo. Depois de ter uma experi��ncia de ��xtase vision��rio ele �� violentamente assassinado. Lucas, todavia, descreve Estev��o como her��i vitorioso. A realidade de conflitos, oposi����o, persegui����o e mart��rio n��o se constitui em derrota, mas em fortalecimento da f��. A morte de Estev��o �� interpretada dentro desta tradi����o. A compreens��o do caso de Estev��o e dos Helenistas �� fundamental para entender a continua����o do movimento dos seguidores de Jesus e o in��cio do desenvolvimento da Cristologia ap��s o evento pascal.(AU)

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

The decrement in dopamine levels exceeds the loss of dopaminergic neurons in Parkinson���s disease (PD) patients and experimental models of PD. This discrepancy is poorly understood and may represent an important event in the pathogenesis of PD. Herein, we report that the rate-limiting enzyme in dopamine synthesis, tyrosine hydroxylase (TH), is a selective target for nitration following exposure of PC12 cells to either peroxynitrite or 1-methyl-4-phenylpyridiniun ion (MPP+). Nitration of TH also occurs in mouse striatum after MPTP administration. Nitration of tyrosine residues in TH results in loss of enzymatic activity. In the mouse striatum, tyrosine nitration-mediated loss in TH activity parallels the decline in dopamine levels whereas the levels of TH protein remain unchanged for the first 6 hr post MPTP injection. Striatal TH was not nitrated in mice overexpressing copper/zinc superoxide dismutase after MPTP administration, supporting a critical role for superoxide in TH tyrosine nitration. These results indicate that tyrosine nitration-induced TH inactivation and consequently dopamine synthesis failure, represents an early and thus far unidentified biochemical event in MPTP neurotoxic process. The resemblance of the MPTP model with PD suggests that a similar phenomenon may occur in PD, influencing the severity of parkisonian symptoms.

Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics

Funded by European Research Council. Grant Number: 339367 UK Biotechnology and Biological Sciences Research Council. Grant Number: K015508/1 The Wellcome Trust. Grant Number: 094476 EPSRC Acknowledgements This work was supported by the European Research Council (339367), UK Biotechnology and Biological Sciences Research Council (K015508/1), The Wellcome Trust (TripleTOF 5600 mass spectrometer (094476), the MALDI TOF-TOF Analyser (079272AIA), 700 NMR) and the EPSRC UK National Mass Spectrometry Facility at Swansea University. J.H.N. is a Royal Society Wolfson Merit Award Holder and 1000 talent scholar at Sichuan University.

Revista moderna : Anno 1, n. 3 (25 julho 1897)

Impressa em papel couch��. De acordo com Ana Luiza Martins em sua obra "Revistas em revista": "A Revista Moderna, impressa em Paris, em 1897, introduzia o que havia de mais avan��ado em periodismo, primando por elaboradas reportagens, coberturas de acontecimentos marcantes do tempo, geralmente ilustradas com desenhos tomados a partir dos acontecimentos, n��o se furtando ao sensacionalismo em voga."

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages dopaminergic neurons in the substantia nigra pars compacta (SNpc) as seen in Parkinson's disease. Here, we show that the pro-apoptotic protein Bax is highly expressed in the SNpc and that its ablation attenuates SNpc developmental neuronal apoptosis. In adult mice, there is an up-regulation of Bax in the SNpc after MPTP administration and a decrease in Bcl-2. These changes parallel MPTP-induced dopaminergic neurodegeneration. We also show that mutant mice lacking Bax are significantly more resistant to MPTP than their wild-type littermates. This study demonstrates that Bax plays a critical role in the MPTP neurotoxic process and suggests that targeting Bax may provide protective benefit in the treatment of Parkinson's disease.