Rare American history, being the library of a well-known Philadelphia collector ... : to be sold Friday afternoon and evening, February 4th, 1910 ... Saturday morning and afternoon, February 5th, 1910 ... oder of slae, first sitting lots 1 to 350, second [sitting] [lots] 351 to 700, third [sitting] [lots] 701 to 1050, fourth [sitting] [lots] 1051 to end /

" ... comprising an extensive collection of works on the North American Indians; a large and select collection of genealogies, an unusual accumulation of church histories, and general American history, embracing state, county and town history, inland voyages and travels, narratives, biographies, bibliography, Revolutionary history, early poetry, &c."

A catalog of the books belonging to the Charleston library society.

Bound with this copy are: "A supplemental catalogue ... of all the books ... procured by the Charleston library society, since the publication of the first volume of their catalogue in 1826", Charleston, 1831; and the "Catalogue of the library of the South Carolina college ... 1836."

Table of the logarithms of the natural numbers from 1 to 108000 /

Mode of access: Internet.

A catalogue of the books belonging to the Library Company of Philadelphia : to which is prefixed, a short account of the institution, with the charter, laws, and regulations.

Vol. i includes list of members. Vol. iii contains additions 1835-56 and index to all three vols.

Biennial report of the Secretary of State of the state of Louisiana for the two years ending May 1, ... to his excellency ..., Governor of Louisiana.

Description based on: May 1, 1882.

Uber 1-3-4-xylenol-5-carbinol.

Thesis (doctoral)--

Monthly Bulletin of Books Added to the Public Library of the City of Boston

Superseded by Boston. Public Library. Weekly List, and Boston. Public Library. Bulletin [1908-23]

Annual List of New and Important Books Added to the Public Library of the City of Boston

Mode of access: Internet.

Modification of Transportation Act, 1920 : hearings ... Sixty-seventh Congress, first session, on S. 1150 and S. 2510 ... October 24 to December 15, 1921, and January 5, 1922.

"Printed for the use of the Committee on Interstate Commerce."

Uber Salzbildung, Umlagerung und Aufspaltung des 1-Phenyl-4-oximido-5-triazolons /

Thesis (doctoral)--K. Bayer. Ludwig-Maximilians- Universitat zu Munchen, 1908.

beta 2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor

The structures of acetylcholine-binding protein ( AChBP) and nicotinic acetylcholine receptor ( nAChR) homology models have been used to interpret data from mutagenesis experiments at the nAChR. However, little is known about AChBP-derived structures as predictive tools. Molecular surface analysis of nAChR models has revealed a conserved cleft as the likely binding site for the 4/7 alpha-conotoxins. Here, we used an alpha 3 beta 2 model to identify beta 2 subunit residues in this cleft and investigated their influence on the binding of alpha-conotoxins MII, PnIA, and GID to the alpha 3 beta 2 nAChR by two-electrode voltage clamp analysis. Although a beta 2-L119Q mutation strongly reduced the affinity of all three alpha-conotoxins, beta 2-F117A, beta 2-V109A, and beta 2-V109G mutations selectively enhanced the binding of MII and GID. An increased activity of alpha-conotoxins GID and MII was also observed when the beta 2-F117A mutant was combined with the alpha 4 instead of the alpha 3 subunit. Investigation of A10L-PnIA indicated that high affinity binding to beta 2-F117A, beta 2-V109A, and beta 2-V109G mutants was conferred by amino acids with a long side chain in position 10 (PnIA numbering). Docking simulations of 4/7 alpha-conotoxin binding to the alpha 3 beta 2 model supported a direct interaction between mutated nAChR residues and alpha-conotoxin residues 6, 7, and 10. Taken together, these data provide evidence that the beta subunit contributes to alpha-conotoxin binding and selectivity and demonstrate that a small cleft leading to the agonist binding site is targeted by alpha-conotoxins to block the nAChR.

Neogenin interacts with RGMa and Netrin-1 to guide axons within the embryonic vertebrate forebrain

In the embryonic forebrain, pioneer axons establish a simple topography of dorsoventral and longitudinal tracts. The cues used by these axons during the initial formation of the axon scaffold remain largely unknown. We have investigated the axon guidance role of Neogenin, a member of the immunoglobulin (Ig) superfamily that binds to the chemoattractive ligand Netrin-1, as well as to the chemorepulsive ligand repulsive guidance molecule (RGMa). Here, we show strong expression of Neogenin and both of its putative ligands in the developing Xenopus forebrain. Neogenin loss-of-function mutants revealed that this receptor was essential for axon guidance in an early forming dorsoventral brain pathway. Similar mutant phenotypes were also observed following loss of either RGMa or Netrin-1. Simultaneous partial knock downs of these molecules revealed dosage-sensitive interactions and confirmed that these receptors and ligands were acting in the same pathway. The results provide the first evidence that Neogenin acts as an axon guidance molecule in vivo and support a model whereby Neogenin-expressing axons respond to a combination of attractive and repulsive cues as they navigate their ventral trajectory. (c) 2006 Elsevier Inc. All rights reserved.