A matrix iteration for dynamic network summaries

We propose a new algorithm for summarizing properties of large-scale time-evolving networks. This type of data, recording connections that come and go over time, is being generated in many modern applications, including telecommunications and on-line human social behavior. The algorithm computes a dynamic measure of how well pairs of nodes can communicate by taking account of routes through the network that respect the arrow of time. We take the conventional approach of downweighting for length (messages become corrupted as they are passed along) and add the novel feature of downweighting for age (messages go out of date). This allows us to generalize widely used Katz-style centrality measures that have proved popular in network science to the case of dynamic networks sampled at non-uniform points in time. We illustrate the new approach on synthetic and real data.

A defined intestinal colonization microbiota for gnotobiotic pigs

Maximising the ability of piglets to survive exposure to pathogens is essential to reduce early piglet mortality, an important factor in efficient commercial pig production. Mortality rates can be influenced by many factors, including early colonization by microbial commensals. Here we describe the development of an intestinal microbiota, the Bristol microbiota, for use in gnotobiotic pigs and its influence on synthesis of systemic immunoglobulins. Such a microbiota will be of value in studies of the consequences of early microbial colonization on development of the intestinal immune system and subsequent susceptibility to disease. Gnotobiotic pig studies lack a well-established intestinal microbiota. The use of the Altered Schaedler Flora (ASF), a murine intestinal microbiota, to colonize the intestines of Caesarean-derived, gnotobiotic pigs prior to gut closure, resulted in unreliable colonization with most (but not all) strains of the ASF. Subsequently, a novel, simpler porcine microbiota was developed. The novel microbiota reliably colonized the length of the intestinal tract when administered to gnotobiotic piglets. No health problems were observed, and the novel microbiota induced a systemic increase in serum immunoglobulins, in particular IgA and IgM. The Bristol microbiota will be of value for highly controlled, reproducible experiments of the consequences of early microbial colonization on susceptibility to disease in neonatal piglets, and as a biomedical model for the impact of microbial colonization on development of the intestinal mucosa and immune system in neonates.

Terminology matters! Why difference is not incompleteness and how early child bilinguals are heritage speakers

This paper integrates research on child simultaneous bilingual (2L1) acquisition more directly into the heritage language (HL) acquisition literature. The 2L1 literature mostly focuses on development in childhood, whereas heritage speakers (HSs) are often tested at an endstate in adulthood. However, insights from child 2L1 acquisition must be considered in HL acquisition theorizing precisely because many HSs are the adult outcomes of child 2L1 acquisition. Data from 2L1 acquisition raises serious questions for the construct of incomplete acquisition, a term broadly used in HL acquisition studies to describe almost any difference HSs display from baseline controls (usually monolinguals). We offer an epistemological discussion related to incomplete acquisition, highlighting the descriptive and theoretical inaccuracy of the term. We focus our discussion on two of several possible causal factors that contribute to variable competence outcomes in adult HSs, input (e.g., Sorace, 2004; Rothman, 2007; Pascual y Cabo & Rothman, 2012) and formal instruction (e.g., Kupisch, 2013; Kupisch et al., 2014) in the HL. We conclude by offering alternative terminology for HS outcomes.

Production of Bovine Hand-Made Cloned Embryos by Zygote-Oocyte Cytoplasmic Hemi-complementation

The aim of this study was to evaluate the effect of the cytoplast type and activation process on development of cloned embryos. Bovine oocytes (MII) or zygotes at the one-cell stage (IVF) were manually bisected and segregated in MII or IVF hemi-cytoplasts or hemi-karyoplasts. Adult skin cells from a bovine female were used as nucleus donors (SC). Experimental groups were composed of IVF embryos; parthenogenetic embryos; handmade cloned (HMC) embryos; and reconstructed HMC embryos using IVF hemi-cytoplast + MII hemi-cytoplast + SC (G-I); IVF hemi-cytoplast + IVF hemi-cytoplast + SC (G-II); MII hemi-cytoplast + IVF hemi-karyoplast (G-III); and IVF hemi-cytoplast + IVF hemi-karyoplast (G-IV). Embryos from G-I to G-IV were allocated to subgroups as sperm-activated (SA) or were further chemically activated (SA + CA). Embryos from all groups and subgroups were in vitro cultured in the WOW system. Blastocyst development in subgroup G-I SA (28.2%) was similar to IVF (27.0%) and HMC (31.4%) controls, perhaps due to a to a more suitable activation process and/or better complementation of cytoplasmic reprogramming factors, with the other groups and subgroups having lower levels of development. No blastocyst development was observed when using IVF hemi-karyoplasts (G-III and G-IV), possibly due to the manipulation process during a sensitive biological period. In summary, the presence of cytoplasmic factors from MII hemi-oocytes and the sperm activation process from hemi-zygotes appear to be necessary for adequate in vitro development, as only the zygote-oocyte hemi-complementation was as efficient as controls for the generation of bovine cloned blastocysts.

Exposure to ambient levels of particles emitted by traffic worsens emphysema in mice

Objectives: We investigated effects of chronic exposure (2 months) to ambient levels of particulate matter (PM) on development of protease-induced emphysema and pulmonary remodeling in mice. Methods: Balb/c mice received nasal drop of either papain or normal saline and were kept in two exposure chambers situated in an area with high traffic density. One of them received ambient air and the other had filters for PM. Results: mean concentration of PM10 was 2.68 +/- 0.38 and 33.86 +/- 2.09 mu g/m(3), respectively, in the filtered and ambient air chambers (p<0.001). After 2 months of exposure, lungs from papain-treated mice kept in the chamber with ambient air presented greater values of mean linear intercept, an increase in density of collagen fibers in alveolar septa and in expression of 8-isoprostane (p = 0.002, p < 0.05 and p = 0.002, respectively, compared to papain-treated mice kept in the chamber with filtered air). We did not observe significant differences between these two groups in density of macrophages and in amount of cells expressing matrix metalloproteinase-12. There were no significant differences in saline-treated mice kept in the two chambers. Conclusions: We conclude that exposure to urban levels of PM worsens protease-induced emphysema and increases pulmonary remodeling. We suggest that an increase in oxidative stress induced by PM exposure influences this response. These pulmonary effects of PM were observed only in mice with emphysema. (C) 2009 Elsevier Inc. All rights reserved.

Intermittent Therapy with 1,25 Vitamin D and Calcitonin Prevents Cyclosporin-Induced Alveolar Bone Loss in Rats

Bone loss associated with cyclosporin A (CsA) therapy can result in serious morbidity to patients. Intermittent administration of 1,25 Vitamin D and calcitonin reduces osteopenia in a murine model of postmenopausal osteoporosis. The purpose of this study was to evaluate the effects of this therapeutic approach on CsA-induced alveolar bone loss in rats. Forty male Wistar rats were allocated to four experimental groups according to the treatment received during 8 weeks: (1) CsA (10 mg/kg/day, s.c.); (2) 1,25 Vitamin D (2 mu g/kg, p.o.; in weeks 1, 3, 5, and 7) plus calcitonin (2 mu g/kg, i.p.; in weeks 2, 4, 6, and 8); (3) CsA concurrently with intermittent 1,25 Vitamin D and calcitonin administration; and (4) the control treatment group (vehicle). At the end of the 8-week treatment period, serum concentrations of bone-specific alkaline phosphatase, tartrate-resistant acid phosphatase (TRAP-5b), osteocalcin, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor alpha (TNF-alpha) were measured and an analysis of bone volume, bone surface, number of osteoblasts, and osteoclasts was performed. CsA administration resulted in significant alveolar bone resorption, as assessed by a lower bone volume and an increased number of osteoclasts, and increased serum bone-specific alkaline phosphatase, TRAP-5b, IL-1 beta, IL-6, and TNF-alpha concentrations. The intermittent administration of calcitriol and calcitonin prevented the CsA-induced osteopenic changes and the increased serum concentrations of TRAP-5b and inflammatory cytokines. Intermittent calcitriol/calcitonin therapy prevents CsA-induced alveolar bone loss in rats and normalizes the production of associated inflammatory mediators.

Quaternary tectonics in a passive margin: Marajo Island, northern Brazil

Marajo Island is located in a passive continental margin that evolved from rifting associated with the opening of the Equatorial South Atlantic Ocean in the Late Jurassic/Early Cretaceous period. This study, based on remote sensing integrated with sedimentology, as well as subsurface and seismographic data available from the literature, allows discussion of the significance of tectonics during the Quaternary history of marginal basins. Results show that eastern Marajo Island contains channels with evidence of tectonic control. Mapping of straight channels defined four main groups of lineaments (i.e. NNE-SSW, NE-SW, NW-SE and E-W) that parallel main normal and strike-slip fault zones recorded for the Amazon region. Additionally, sedimentological studies of late Quaternary and Holocene deposits indicate numerous ductile and brittle structures within stratigraphic horizons bounded by undeformed strata, related to seismogenic deformation during or shortly after sediment deposition. This conclusion is consistent with subsurface Bouguer mapping suggestive of eastern Marajo Island being still part of the Marajo graben system, where important fault reactivation is recorded up to the Quaternary. Together with the recognition of several phases of fault reactivation, these data suggest that faults developed in association with rift basins might remain active in passive margins, imposing important control on development of depositional systems. Copyright (C) 2007 John Wiley & Sons, Ltd.

Hur eller Varför? : Kunskap i sociokulturellt eller existentialistiskt perspektiv? En kritisk betraktelse

This essay set out to propose a problematic interpretation of the socio-cultural perspective on learning. Its purpose is to show how the socio-cultural perspective on learning defines the concept of knowledge in an incomplete way. The aim becomes then that of giving a more comprehensive description of this concept, and, to this end, to construct a new, broader pedagogic discourse. The investigation starts with a deconstructive analysis of Roger Säljö’s socio-cultural text in order to point out the incompleteness of the concept of knowledge. The constructive part of the analysis proceeds using Heidegger’s and Sartre’s philosophical theories which take a general approach on human learning and on human knowledge as dependent on intuition. A dichotomy of two new concepts related to knowledge is thus defined: how-knowledge and why-knowledge. This reconceptualisation of the concept of knowledge allows a reinterpretation of any act of knowledge in a structural way. Hence any act of knowledge includes a moment (a) which defines the initial contextual (conceptual or practical) situation; a moment (b) which represents an algorithm, a procedure, or a theory; and a moment (c) which represents the result of the act, and is the direct application of knowledge as a finalized entity. Knowledge inbuilt in (a) and (c) is characterized as how-knowledge, while that in (b) is characterized as why-knowledge. In a learning situation a focus on how-knowledge implies finality and objectification of students. Conversely, why-knowledge implies students becoming subjects of their own learning.

Åtgärdsprogram för elever i behov av särskilt stöd : Pedagogers förhållningssätt gentemot hantering av elever som saknar diagnos men har ett åtgärdsprogram

Syftet med denna studie har varit att ta reda på lärares och specialpedagogers förhållningssätt gentemot pedagogisk hantering av elever som saknar diagnos men har ett åtgärdsprogram. För att besvara studiens frågeställningar har både kvalitativ och kvantitativ metodansats valts samt kombinerats. Resultatet bygger på frågeställningarnas tre teman: åtgärdsprogrammets nytta, undervisningens utformning samt kriterier för utvärdering och revidering. Resultatet visar att dessa frågor är komplexa dilemman bestående av flera beståndsdelar, dels på grund av spänningen mellan målstyrning och enskilda skolors specifika omständigheter och dels utifrån pedagogernas skilda uppfattningar om pedagogik och specialpedagogik.

Flipped classroom and learning strategies

This paper seeks to answer the research question "How does the flipped classroom affect students’ learning strategies?" In e-learning research, several studies have focused on how students and teachers perceive the flipped classroom approach. In general, these studies have reported pleasing results. Nonetheless, few, if any, studies have attempted to find out the potential effects of the flipped classroom approach on how students learn. This study was based on two cases: 1) a business modelling course and 2) a research methodology course. In both cases, participating students were from information systems courses at Dalarna University in Sweden. Recorded lectures replaced regular lectures. The recorded lectures were followed by seminars that focused on the learning content of each lecture in various ways. Three weeks after the final seminar, we arranged for two focus group interviews to take place in each course, with 8 to 10 students participating in each group. We asked open questions on how the students thought they had been affected and more dedicated questions that were generated from a literature study on the effects of flipped classroom courses. These questions dealt with issues about mobility, the potential for repeating lectures, formative feedback, the role of seminars, responsibility, empowerment, lectures before seminars, and any problems encountered. Our results show that, in general, students thought differently about learning after the courses in relation to more traditional approaches, especially regarding the need to be more active. Most students enjoyed the mobility aspect and the accessibility of recorded lectures, although a few claimed it demanded a more disciplined attitude. Most students also expressed a feeling of increased activity and responsibility when participating in seminars. Some even felt empowered because they could influence seminar content. The length of and possibility to navigate in recorded lectures was also considered important. The arrangement of the seminar rooms should promote face-to-face discussions. Finally, the types of questions and tasks were found to affect the outcomes of the seminars. The overall conclusion with regard to students’ learning strategies is that to be an active, responsible, empowered, and critical student you have to be an informed student with possibilities and mandate to influence how, where and when to learn and be able to receive continuous feedback during the learning process. Flipped classroom can support such learning.

Efeitos da mal nutrição protéica sobre o metabolismo da glicina em cerebelo de ratos durante o seu desenvolvimento

Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of brain development (1). All restriction of protein during the perinatal period of life can alter the development of mammalian fetus and have marked repercussions on development of the Central Nervous System (CNS). The brain is vulnerable to protein malnutrition with altered morphologic and biochemical maturation, leading to impaired functions. The focus of this study is to investigate [U-14C]glycine metabolism in malnourished rats submitted to pre- and postnatal protein deprivation (diet: 8% protein with addition and without addition of L-methionine) on glycine metabolism of rats (normonourished group: 25% protein). It was observed that protein malnutrition alters oxidation to CO2, conversion to lipids and protein synthesis from [U-14C]glycine in cerebellum of malnourished rats without addition of L-methionine on a diet at 7 and 21 days of postnatal life. Our results also indicate that protein malnutrition causes a retardation in the normally ordered progression of brain development, and the malnourished groups have smaller cells, reduction in cell numbers and smaller cerebellar weight comparing to the control group.

Modas e modismos em gestão empresarial: uma pesquisa empírica sobre sistemas integrados de gestão (ERP) no Brasil

Este trabalho discute a onda dos Sistemas Integrados de Gestão (SIG). SIG representam imensos investimentos para empresas em todo o mundo e tem sido promovidos como panacéias gerenciais. Previsivelmente, muitas implantações não atendem as expectativas. Neste estudo, nós: (i) propomos uma perspectiva ampla para a compreensão dos fatores substantivos, institucionais e políticos envolvidos no fenômeno SIG, assim como uma alternativa ao "tecno-reducionismo" que tem caracterizado as abordagens usuais ao tema; e (ii) apresentamos uma pesquisa exploratória de 28 experiências de implantação, concentrando o foco no processo de adoção, na abordagem escolhida para implantação e na avaliação dos resultados.

Administração estratégica em hospitais

Trata-se de análise comparativa do processo de construção da administração estratégica em hospitais de Atlanta (EUA) e São Paulo (Brasil) sob a ótica de executivos dos respectivos hospitais. O estudo das diversas abordagens utilizadas por esses hospitais poderá contribuir para a discussão sobre a importância da aplicação de técnicas modernas de gestão e de um modelo sistemático de administração estratégica em hospitais. Além disso, os resultados fornecem pistas sobre tendências dos mercados de saúde brasileiro e americano e sobre os desafios para os quais os executivos hospitalares devem estar preparados.

A contribuição dos conceitos da gestão da mudança para as relações entre civis e militares no campo político orçamentário

O objetivo deste estudo é entender como se dão as relações entre civis e militares no campo político-orçamentário e identificar as possíveis contribuições dos conceitos da gestão da mudança para essas relações. Utilizando-se paradigmas diferentes em busca de um todo mais completo, é construído o referencial teórico sobre assuntos necessários a compreensão de como se dão essas relações no atual campo político-orçamentário brasileiro. A democracia e o equilíbrio entre as características que marca as relações democráticas; o orçamento como um campo em que se buscam obter interesses, de acordo com normas específicas e relações de poder entre indivíduos e grupos; as relações entre civis e militares, não como uma relação dicotômica, mas como uma imbricada relação entre redes de interesse. O discurso é entendido como a principal ferramenta de mudança social nesse campo e procura-se analisar como utilizá-lo. A gestão da mudança é discutida como prática discursiva que gera mudanças tanto no interior da organização como fora dela, sendo capaz de gerar verdade para a sociedade e conquistar e manter a legitimidade, fonte dos meios de sobrevivência da organização. Por fim, busca-se analisar a gestão da mudança, primeiro em organizações que obtiveram sucesso ao aplicá-las e, em seguida, faz-se uma análise de iniciativas da gestão da mudança aplicadas à Marinha e do seu potencial em produzir as mudanças necessárias no campo político-orçamentário. São levantadas conclusões que oferecem um roteiro de medidas para utilizar a gestão da mudança no aperfeiçoamento das relações democráticas entre civis e militares no campo político-orçamentário brasileiro.

O usuário e os sistemas de informatização: a utilização do sistema de controle de operações da delegacia legal pelos policiais civis do Estado do Rio De Janeiro.

Organizar racionalmente as informações e sistematizá-las tem sido essencial para o sucesso de diversas empresas. Quando estudamos as instituições destinadas à segurança pública percebemos que o uso de tecnologia e de sistemas de informação são comuns nos exemplos bem sucedidos de combate às práticas criminosas. O Programa Delegacia Legal, inaugurado no Estado do Rio de Janeiro em 1999, acompanha essa tendência e tem como um dos seus pilares a importância ao tratamento da informação. Os policiais que fazem os registros das ocorrências nas delegacias utilizando-se do Sistema de informação (SCO) têm então um papel fundamental porque através desses registros são investigadas as infrações, assim como é alimentado um banco de dados mais completo para ser aliado na elaboração de estatísticas e na aplicação de ações estratégicas. Considerando que esse tipo de registro, utilizando sistemas de informação, alterou a rotina institucional, o presente estudo verifica se existe ou não resistência ao uso do Sistema – SCO, fazendo uma abordagem sobre o sistema de informação, o Programa Delegacia Legal, a cultura organizacional e a opinião dos policiais.