Biogeographic range expansion into South America by Coccidioides immitis mirrors New World patterns of human migration

Long-distance population dispersal leaves its characteristic signature in genomes, namely, reduced diversity and increased linkage between genetic markers. This signature enables historical patterns of range expansion to be traced. Herein, we use microsatellite loci from the human pathogen Coccidioides immitis to show that genetic diversity in this fungus is geographically partitioned throughout North America. In contrast, analyses of South American C. immitis show that this population is genetically depauperate and was founded from a single North American population centered in Texas. Variances of allele distributions show that South American C. immitis have undergone rapid population growth, consistent with an epidemic increase in postcolonization population size. Herein, we estimate the introduction into South America to have occurred within the last 9,000–140,000 years. This range increase parallels that of Homo sapiens. Because of known associations between Amerindians and this fungus, we suggest that the colonization of South America by C. immitis represents a relatively recent and rapid codispersal of a host and its pathogen.

Memory from the dynamics of intrinsic membrane currents

Almost all theoretical and experimental studies of the mechanisms underlying learning and memory focus on synaptic efficacy and make the implicit assumption that changes in synaptic efficacy are both necessary and sufficient to account for learning and memory. However, network dynamics depends on the complex interaction between intrinsic membrane properties and synaptic strengths and time courses. Furthermore, neuronal activity itself modifies not only synaptic efficacy but also the intrinsic membrane properties of neurons. This paper presents examples demonstrating that neurons with complex temporal dynamics can provide short-term “memory” mechanisms that rely solely on intrinsic neuronal properties. Additionally, we discuss the potential role that activity may play in long-term modification of intrinsic neuronal properties. While not replacing synaptic plasticity as a powerful learning mechanism, these examples suggest that memory in networks results from an ongoing interplay between changes in synaptic efficacy and intrinsic membrane properties.

Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry

We recently have introduced the term vasculogenic mimicry to describe the unique ability of aggressive melanoma tumor cells to form tubular structures and patterned networks in three-dimensional culture, which “mimics” embryonic vasculogenic networks formed by differentiating endothelial cells. In the current study, we address the biological significance of several endothelial-associated molecules (revealed by microarray analysis) with respect to expression and function in highly aggressive and poorly aggressive human cutaneous melanoma cell lines (established from the same patient). In a comparative analysis, CD31 was not expressed by any of the melanoma cell lines, whereas TIE-1 (tyrosine kinase with Ig and epidermal growth factor homology domains-1) was strongly expressed in the highly aggressive tumor cells with a low level of expression in one of the poorly aggressive cell lines. Vascular endothelial (VE)-cadherin was exclusively expressed by highly aggressive melanoma cells and was undetectable in the poorly aggressive tumor cells, suggesting the possibility of a vasculogenic switch. Down-regulation of VE-cadherin expression in the aggressive melanoma cells abrogated their ability to form vasculogenic networks and directly tested the hypothesis that VE-cadherin is critical in melanoma vasculogenic mimicry. These results highlight the plasticity of aggressive melanoma cells and call into question their possible genetic reversion to an embryonic phenotype. This finding could pose a significant clinical challenge in targeting tumor cells that may masquerade as circulating endothelial cells or other embryonic-like stem cells.

UM Women's Track Team, 1990

Outside Row, standing, bottom left to top to bottom right) Sarah Neely, Carrie Yates, Nicole Chinavare, Jennifer Reed, Stephanie Frohock, Shana Parrish, Dyan Jenkins, Karen Welke, Jennifer McPeck, Gillian Osborne, Judy Yuhn, Amy Bannister, Mindy Rowand

Front Row (kneeling): Ronda Ricketts, Andrea Baas, Alexis Collins, Amy McCormick, Kim Haluscsak, Julie Victor, Sandy Elliott, Lisa Adams

2nd Row: Kirsten McDonald, Michelle Bishop, Gina Barnett, Molly McClimon, Alana Davis, Amy Bucholz

3rd Row: Suzette Thweatt, Alison Smith, Megan Nortz

UM Women's Track Team, 1997

Front Row : Brandy Taylor, Sarah Hamilton, Mara Guillemette, Jen Petersen, Kenise Bocage, Brandi Bentley, Nicole Forrester, Erica Murdock, Atiya Bussey, Sara Barnard, Anica Felton, Katie McGregor.

Row 2: Cryma Williams, Shaunetta Smith, Lisa Ouellet, Allison Noe, Hayley Wilkins, Jen Carlson, Bobbi Devon, Nell Shields, Heather Burcar, Ebony McClain, Gina Merola, Vanessa Lewis, Michael Weber.

Row 3: Tiffin Goodman, Lindsey Martinson, Elizabeth Kampfe, Julie Froud, Marcella Cornell, Angie Stanifer, Nikki Keith, Sarah Clauw, Olive Ikeh, Michelle Slater, Bridget Mann.

Back 4: Tiffany Silvertooth, Eileen Fleck, Tonya Cornell, Stephanie Wigness, Jennifer Allen, Maria Brown, Tania Longe, Tiffany Hodge, Katy Hollbacher, Vanessa Smith.

Diccionario de peruanismos. Ensayo filológico

"Bibliografía de las obras menos conocidas que se citan en este Diccionario y que no han sido registradas en la página ix": v.2, p.523-525.

La doctrina Monroe : su evolución histórica /

"De los Anales de la Facultad de Derecho y Ciencias Sociales, tomo XX, página 65 y siguientes."

Determining discharge-coefficient ratings for selected coastal control structures in Broward and Palm Beach counties, Florida /

Shipping list no.: 99-0001-P.

Sebastiani Serlii Bononiensis De architectvra libri qvinqve ... : necnon extraordinarius quinquaginta portarum libellus in operis calce adiunctus hic demum conspicitur /

Errata, p. [449].

The forbidden man; a novel.

Mode of access: Internet.

Limehouse nights : tales of Chinatown /

Short stories.

School of Nursing Class of 1992

Top Row: Lisa M. Badalament, Heidi S. Bailey, Bonita Ballard, Betsy M. Bateman, Virginia Blackmer, Andrea L. Bonfield, Michelle L. Brown, Jane M. Christie, Gina M. Connolly, Matthew Cornell

Row 2: Mary M. Daugherty, Nancy L. Dewey, Linnette Drzewiecki, Jennifer Farah, Kelly S. Fonger, Yolanda Gardner, Kimberly A. Germain, Kelley Goetz, Laura M. Gonzalez, Melissa Gorr, Julie A. Hale, Jennifer Henstock

Row 3: Charles Houghtby III, Jennifer Hughes, Jill C. Jennings, Renee Manshardt, Jill A. Holquist, Paula R. Cowall, Kristen A. George, Michelle Ingram, Amy Jacobs

Row 4: Tara James, David Jansma, Debra A. Jorgenson, Sherry Keener

Row 5: Karen L. Kelley, Sunnah Kim, Tina Koonter-Banks, Jennifer Kratt

Row 6: Cynthia L. Lazaros, Christine Morelli, Charlotte Murphy, Sharon K. Norton

Row 7: Deborah Oliverio, Karla J. Pontier, Nicole Pruett, Laura Rankin, Jill E. Read, Diane Rosati

Row 8: Katherine E. Ross, Lisa Rubin, Lorie K. Sandberg, Violet Barkauskas, Janice Lindberg, Shake Ketefian, Elisabeth Pennington, Beverly Jones, Donita M. Shaum, Marcie S. Skinner, Julie M. Smallegan

Row 9: K. Christy Spencer, Danette L. Starr, Pamela S. Steele, Dena Stempien-Runyon, Jennifer J. Treacy, Patrica Van Maanen, Roberta Wahl, Marie A. White, Kim Wiersma, Wendy Williams, Dana Wilson

School of Nursing Class of 2000

Top Row: Michelle Arsulowicz, Christy L. baginski, Sarah Ball, Jessica Beitner, Gina Blank, Kelley Brown, Cheryl Buckler, Loredana Bugan, Kelly Burrows, Cynthia Carillo, Raquel Casarez, Rachel Cieslak, Nicole Clark, Stephanie Cochran, John condon

Row 2: Becky Cooper, Claire Coughlan, Heidi M. Dillenbeck, Jennfier Long, Tracy Adame, Stacy B. Buchanan, Tiffany A. Fellberg, Elise H. Peterson, Jessica Na, Abigail Sikkenga, Michelle, Falatko, Lisa Dolan, Laura Dorman, Suzanne Ewald

Row 3: Heather Fix, Anna galczyk, Inessa Gankin, Elizabeth Gardner, Jennfier Gray, Katy Gudritz, Lindsey Hancock, Christina Haremski, Marcie Harless, Anne Hartgerink

Row 4: Benjamin Hatchett, Karrie Herdus, Lacy Hillman, Amy Hlavka, Nicole Holt, Julie Huss, Jessica Inwood, Sujuan Johnson, Nicole N. Jones, Jennfier M. kenny

Row 5: Lori Khami, Jennifer Kiebler, Nipa Kinariwala, Kelli Kingma, Elizabeth Kubis, Jillian LaPrairie, Heather Livermore, Emily Long-Minard, Miki Loveland, Meyhan Manion, David Markiewicz, Dareth McCoy

Row 6: Kerri McElmeel, Suzanne McQuaid, Katie Murphy, Marie Murray, Nola Pender, Carol Loveland-Cherry, Ada Sue Hinshaw, Susan Boehm, Beverly Jones, Patricia coleman-Burns, Darlene Najor, Kelly Nowak, Charisse Patterson, Jennfier Pliska

Row 7: Heather Prusi, Erika Punches, Gena ramazetti, Kimberly Rendz, Suzanne Robben, Sara Robbins, Lori rottschafer, Annette Sandretto, Sara Schad, Chad Schenavar, Jennifer Seamon, Katherine Shell, Charlotte L. Sims, Caryn Steenland, Andrea Stutzman

Row 8: Jennifer Thibault, stacey Turnipseed, Linda Twomey, Stephanie Van Eyk, Maryanne VanNasdale, Annemarie Vassalo, Anna Walawender, Mark Warren, Nicole Weber, Kindra Weid, Lela Shitley, Kristy Wierzba, Shari Wilkinson, Lily Wu

School of Nursing Class of 2007

Top Row: Alexis Adamjee, Jennifer Ahlquist, Crista Andress, Dawn Arringdale, Freda Ayensu, Genevieve Balangero, Maureen Berlucchi, Amanda Bevier, Nina Bibicoff, Rachel Black, Denise Black, Jackie Braun, Kristen Bryant, Betty Burgner, Julie Butchart, Nicholas Cameron, Jessica Carver, Christine Cha, Kelly Clement

Row 2: Lauren Cochran, Kathleen Connell, Amanada Cooperwasser, Lindsay Cousino, Lindsey Evans, Stephen Kilijanczyk, Kathryn Evans, Kathryn Bucrek, Ida Elise Broadwater, Renee Havey, Sharon Warner, Katie Darnell, Katrina DeWitt, Kolleen Kowalske, Keather Rechtweg, Kristen Cowan, Alison Damioli, Dinah Denton, Melinda Dobie

Row 3: Rosemarie Donnelly, Kelly Doyle, Deanna Dusseau, Jacqueline Elegant, Ashley Faulk, Kristin Ferszt, Christine Catalan, Sarah Borgstadt-Smith, Paul Holtz, Tracy Jakubiec, Chemari Justice, Patricia Oppenheim, Kelly Fleming, Melissa Foster, Emily French, Tracy Gallo, Kathie Garrett, Jacqueline Garry

Row 4: Monique Gennari, Megan Gerlinger, Deborah Glazer, Terah Griggs, Edward Grosser, Kristy Haigh, Amanda Halbert, Jennifer Hammer, Emily Harris, Erin Harris, Elizabeth Hassenrik, Elizabeth Heinbeck

Row 5: Brianna Hirsch, Jessica Hoffman, Heather Hoffner, Bridget Holtz, Melissa Housefield, Sarah Hudson, Kathy Huffnagle, Hilary Hunt, Ashley Jannesen, Lauren Jarvis, Sarah Jarvis, Younhee Jee

Row 6: Ruth Jensen, Janet Wilson Johnston, Brandi Josephs, Amy Kangwankij, Julie Kramb, Dianna Krankurs, Allan Kucab, Kimberly Lai, Sarah Layher, Erin Layher, Dung Le, Hedy Leiter

Row 7: Lauren Loftus, Michael Long, Caroline Loukotka, Shoshana Love, Norma Martinez, Kristen McElreath, Lindsi McErlean, Renee McGlone, Lynne McIntosh, Ian McLelland, Ashley Mester, Anika Meyers

Row 8: Elizabeth Miles, Sarah Miller, Juliana Moore, Nicole Nastanski, Sarah Neighbours, Emily Newman, Judith Lynch-Sauer, Patricia Coleman-Burns, Judith Wismont, Kathleen Potempa, Carol Loveland-Cherry, Carolyn Sampselle, Joanne Pohl, Katie Pace, Bethany Panyard, sejal Patel, Chelsea Patnoude, Amy Jo Perry, Joseph Piotrowski

Row 9: Kate Pittel, Natalie Podolsky, Jessica Pollman, Nicole Pratt, Laura Ready, Amanda Retzbach, Katie Richards, Nicole Rico, April Robertson, Meighan Robinson, Stephanie Robinson, Talia Roesner, Autumn Romanowski, Anne Sage, Sally Scharg, Melissa Schultz, Renee Shelton, Natalie Sherry

Row 10: Rebecca Siereveld, Karen Simon, Emily Sosnowski, Elissa Stier, Darcy Stoll, Nicole Sukich, Erin Sykes-Miller, Tami Szuba, John Tallman, Michelle Taylor, Ashley Thelen, Gina Thomas, Rachel Tovian, Yuanyuan Wan, Nicole Young