Valorizzazione e restauro delle mura di borgo San Giuliano in Rimini: facilitazione alla lettura e nuovi percorsi archeologici romano-medievali

Il lavoro di tesi si pone l'obiettivo di valorizzare la cinta muraria medievale della città di Rimini attraverso la progettazione di un sistema di percorsi archeologici, analizzando le criticità e sviluppando linee guida per il restauro e la riqualificazione dell’ambiente circostante. Il lavoro è diviso in fasi: 1-Ricerca storica di tipo archivistico e iconografico per indagare l’evoluzione del sistema difensivo partendo dalle origini fino alle recenti demolizioni. 2-Sulla base delle trilaterazioni in possesso, si è proceduto al rilievo diretto della cinta muraria di San Giuliano con l’obiettivo di comprendere la fabbrica delle mura e restituire graficamente lo stato dell’opera nelle parti che la compongono, in particolare della torre malatestiana e la scala riportandole informazioni necessarie al restauro. Si sono poi rilevate le criticità dell’area circostante le mura. 3-Si è elaborata una proposta progettuale di restauro in merito: -alla riqualificazione del parco con un progetto di restauro urbano degli spazi verdi e dei percorsi ciclo-pedonali per facilitare la lettura del tracciato storico e favorire la fruizione ai cittadini creando punti di ritrovo e di sosta; -alle mura, fondata sui principi di reversibilità, distinguibilità e minimo intervento restituendo un’idea volumetrica dell'immagine interrotta del monumento, minimi interventi di ripristino, la chiusura del varco incongruo della torre; -ai percorsi archeologici per facilitare la lettura della cinta muraria creando un sistema circolare sia interno che esterno tramite l’installazione di segnaletica sia orizzontale che verticale e la realizzazione di nuovi percorsi ciclo-pedonali collegati a quelli già esistenti. Nell’iter progettuale si sono voluti raggiungere il recupero e la valorizzazione dell’intera cinta muraria riminese collegando diversi interventi puntuali realizzati nel recente passato tramite un sistema organico di opere atte a fornire un’unità di linguaggio facilmente riconoscibile.

Caso Marcela: análise de caso clínico da influenza

Caso clínico do Curso de Atualização do Manejo Clínico da Influenza, ofertado pela Secretaria de Vigilância em Saúde e Universidade Aberta do Sistema Único de Saúde - UNASUS. Discute o caso de uma paciente de 22 anos, na 30ª semana de gestação, com pré-natal em dia, sem intercorências até então. Em uma manhã de inverno procura a unidade de saúde com queixas de febre alta, dor de garvanta e tosse seca. Nega dor toráxica ou dispinéia, e nega também dor abdominal. Não tomou a vacina de infuenza, apesar da recomendação feita durente seu pré-natal.

Caso Marcela [exercício]

Questões objetivas de múltipla escolha que avaliam as competências em realização de consulta pré-natal com abordagem ampla, desde a pré-concepção, diagnóstico gestacional, acompanhamento (vacinas, suplementações, nutrição, exames complementares e principais problemas); diagnóstico e acompanhamento, conjuntamente com especialista focal, a doença hipertensiva na gravidez; realização da consulta de puerpério. Assuntos abordados no Caso Clínico Marcela.

Caso Marcela: aleitamento materno [exercício]

Palavras cruzadas sobre aleitamento materno

Influenza: caso Marcela

Caso clínico do Curso de Atualização do Manejo Clínico da Influenza, ofertado pela Secretaria de Vigilância em Saúde e Universidade Aberta do Sistema Único de Saúde - UNA-SUS. Discute o caso de uma paciente de 22 anos, na 30ª semana de gestação, com pré-natal em dia, sem intercorências até então. Em uma manhã de inverno procura a unidade de saúde com queixas de febre alta, dor de garvanta e tosse seca. Nega dor toráxica ou dispinéia, e nega também dor abdominal. Não tomou a vacina de infuenza, apesar da recomendação feita durente seu pré-natal.

The Putative Leishmania Telomerase Rna (leishter) Undergoes Trans-splicing And Contains A Conserved Template Sequence.

Telomerase RNAs (TERs) are highly divergent between species, varying in size and sequence composition. Here, we identify a candidate for the telomerase RNA component of Leishmania genus, which includes species that cause leishmaniasis, a neglected tropical disease. Merging a thorough computational screening combined with RNA-seq evidence, we mapped a non-coding RNA gene localized in a syntenic locus on chromosome 25 of five Leishmania species that shares partial synteny with both Trypanosoma brucei TER locus and a putative TER candidate-containing locus of Crithidia fasciculata. Using target-driven molecular biology approaches, we detected a ∼2,100 nt transcript (LeishTER) that contains a 5' spliced leader (SL) cap, a putative 3' polyA tail and a predicted C/D box snoRNA domain. LeishTER is expressed at similar levels in the logarithmic and stationary growth phases of promastigote forms. A 5'SL capped LeishTER co-immunoprecipitated and co-localized with the telomerase protein component (TERT) in a cell cycle-dependent manner. Prediction of its secondary structure strongly suggests the existence of a bona fide single-stranded template sequence and a conserved C[U/C]GUCA motif-containing helix II, representing the template boundary element. This study paves the way for further investigations on the biogenesis of parasite TERT ribonucleoproteins (RNPs) and its role in parasite telomere biology.

Fracture Of Distal Humerus: Mipo Technique With Visualization Of The Radial Nerve.

To evaluate the outcomes in patients treated for humerus distal third fractures with MIPO technique and visualization of the radial nerve by an accessory approach, in those without radial palsy before surgery. The patients were treated with MIPO technique. The visualization and isolation of the radial nerve was done by an approach between the brachialis and the brachiorradialis, with an oblique incision, in the lateral side of the arm. MEPS was used to evaluate the elbow function. Seven patients were evaluated with a mean age of 29.8 years old. The average follow up was 29.85 months. The radial neuropraxis after surgery occurred in three patients. The sensorial recovery occurred after 3.16 months on average and also of the motor function, after 5.33 months on average, in all patients. We achieved fracture consolidation in all patients (M=4.22 months). The averages for flexion-extension and prono-supination were 112.85° and 145°, respectively. The MEPS average score was 86.42. There was no case of infection. This approach allowed excluding a radial nerve interposition on site of the fracture and/or under the plate, showing a high level of consolidation of the fracture and a good evolution of the range of movement of the elbow. Level of Evidence IV, Case Series.

Rhinosinusitis: Evidence And Experience. A Summary.

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Graphene Oxide: A Carrier For Pharmaceuticals And A Scaffold For Cell Interactions.

During the last ten years, graphene oxide has been explored in many applications due to its remarkable electroconductivity, thermal properties and mobility of charge carriers, among other properties. As discussed in this review, the literature suggests that a total characterization of graphene oxide must be conducted because oxidation debris (synthesis impurities) present in the graphene oxides could act as a graphene oxide surfactant, stabilizing aqueous dispersions. It is also important to note that the structure models of graphene oxide need to be revisited because of significant implications for its chemical composition and its direct covalent functionalization. Another aspect that is discussed is the need to consider graphene oxide surface chemistry. The hemolysis assay is recommended as a reliable test for the preliminary assessment of graphene oxide toxicity, biocompatibility and cell membrane interaction. More recently, graphene oxide has been extensively explored for drug delivery applications. An important increase in research efforts in this emerging field is clearly represented by the hundreds of related publications per year, including some reviews. Many studies have been performed to explore the graphene oxide properties that enable it to deliver more than one activity simultaneously and to combine multidrug systems with photothermal therapy, indicating that graphene oxide is an attractive tool to overcome hurdles in cancer therapies. Some strategic aspects of the application of these materials in cancer treatment are also discussed. In vitro studies have indicated that graphene oxide can also promote stem cell adhesion, growth and differentiation, and this review discusses the recent and pertinent findings regarding graphene oxide as a valuable nanomaterial for stem cell research in medicine. The protein corona is a key concept in nanomedicine and nanotoxicology because it provides a biomolecular identity for nanomaterials in a biological environment. Understanding protein corona-nanomaterial interactions and their influence on cellular responses is a challenging task at the nanobiointerface. New aspects and developments in this area are discussed.

Tecnologia de nanocristais em fármacos

The use of poorly water soluble molecules in pharmaceutical area has grown. Since these molecules exhibit low oral bioavailability, they are not used in intravenous administrations. Therefore, it is necessary to develop their new formulations with the aim to increase their oral bioavailabilities as to enable intravenous applications. One of the few possibilities in achieving this is a nanonization process that can produce crystals smaller than 1 μm by high pressure homogenization and without use of organic solvents. This mini-review describes technical aspects of the nanocrystal production, morphological aspects (polymorphisms), the market relevance of the nanocrystals products that are already in clinical phase or at the market, as well as, perspectives for the near future.

Quality of life in patients with ileal pouch for ulcerative colitis

INTRODUCTION:proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the standard surgical procedure for the treatment of ulcerative colitis (UC) and is associated with the prospect of cure. Experience gained over the years has demonstrated the occurrence of a high number of complications as well as bowel disorders that can compromise quality of life (QoL).OBJECTIVE:evaluate QoL in patients with IPAA for ulcerative colitis.PATIENTS AND METHODS:the Inflammatory Bowel Disease Questionnaire (IBDQ) was used to assess QoL in patients with IPAA after its validation in Portuguese.RESULTS:thirty-one patients submitted to IPAA by the same group of professionals were evaluated. QoL was classified as regular in all domains evaluated (intestinal and systemic symptoms and emotional and social aspects). There were no differences in relation to gender, type of pouch or postoperative time. However, elderly patients showed a tendency toward lower scores. Having a professional activity was associated with higher scores in systemic symptoms and social aspects (p < 0.05). Patients with ileostomy showed lower values in the domains of systemic symptoms, emotional and social aspects (p <0.05).CONCLUSION:in all domains assessed, patients with IPAA for UC had QoL classified as regular. Ileostomy and lack of professional activity negatively influenced QoL.

Comparação entre o dano muscular de flexores do cotovelo e extensores do joelho em idosos= : Muscle damage comparison between elbow flexors and knee extensors in older adults

Universidade Estadual de Campinas . Faculdade de Educação Física

Contribution Of Antepartum And Intrapartum Hemorrhage To The Burden Of Maternal Near Miss And Death In A National Surveillance Study

Objective To evaluate the occurrence of severe obstetric complications associated with antepartum and intrapartum hemorrhage among women from the Brazilian Network for Surveillance of Severe Maternal Morbidity.Design Multicenter cross-sectional study.Setting Twenty-seven obstetric referral units in Brazil between July 2009 and June 2010.Population A total of 9555 women categorized as having obstetric complications.Methods The occurrence of potentially life-threatening conditions, maternal near miss and maternal deaths associated with antepartum and intrapartum hemorrhage was evaluated. Sociodemographic and obstetric characteristics and the use of criteria for management of severe bleeding were also assessed in these women.Main outcome measures The prevalence ratios with their respective 95% confidence intervals adjusted for the cluster effect of the design, and multiple logistic regression analysis were performed to identify factors independently associated with the occurrence of severe maternal outcome.Results Antepartum and intrapartum hemorrhage occurred in only 8% (767) of women experiencing any type of obstetric complication. However, it was responsible for 18.2% (140) of maternal near miss and 10% (14) of maternal death cases. On multivariate analysis, maternal age and previous cesarean section were shown to be independently associated with an increased risk of severe maternal outcome (near miss or death).Conclusion Severe maternal outcome due to antepartum and intrapartum hemorrhage was highly prevalent among Brazilian women. Certain risk factors, maternal age and previous cesarean delivery in particular, were associated with the occurrence of bleeding.

Extrações dentárias em Ortodontia: avaliação de elementos de diagnóstico

Algumas más oclusões exigem do ortodontista capacidade de diagnóstico para decidir pela melhor maneira de tratar o paciente. O objetivo dos autores deste artigo foi apresentar casos clínicos e discutir alguns elementos de diagnóstico utilizados na elaboração do plano de tratamento, auxiliando na decisão de extrair dentes. Foi dada ênfase em cada elemento de diagnóstico: aspectos relacionados à cooperação, discrepância de modelo, discrepância cefalométrica e perfil facial, idade esquelética (crescimento) e relações anteroposteriores, assimetrias dentárias, padrão facial e patologias. Sugere-se que a associação dos aspectos citados é importante para a decisão correta. Todavia, algumas vezes, uma característica, por si só, pode definir o plano de tratamento.

Extração de incisivo inferior: uma opção de tratamento ortodôntico

A exodontia de um incisivo inferior pode ser considerada uma opção valiosa na busca de excelência nos resultados ortodônticos para obtenção de máxima função, estética e estabilidade. O objetivo deste estudo foi reunir informações referentes às indicações, contraindicações, vantagens, desvantagens e estabilidade dos resultados obtidos nos tratamentos realizados com extração de um incisivo inferior. Essa opção de tratamento pode ser indicada em más oclusões com discrepância de volume dentário anterior devido a incisivos superiores estreitos e/ou incisivos inferiores largos. É contraindicada em más oclusões sem discrepância anterior ou com discrepâncias ocasionadas por incisivos superiores largos e/ou incisivos inferiores estreitos. A literatura sugere maior estabilidade pós-tratamento quando comparada com a opção de extrações de pré-molares. Além do diagnóstico cuidadoso, obtido com a colaboração do set-up, a habilidade e a experiência clínica do profissional são importantes para o sucesso dos resultados ortodônticos alcançados com essa opção de tratamento