896 resultados para Restructuring
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The land question has been a widely discussed topic in Brazil, regarding land tenure. Law No. 10.267/01 was a major breakthrough for the agrarian issue. Since then on all rural properties must be georeferenced to the Brazilian Geodetic System (BGS). Therefore, satellite positioning and conventional methods are extensively used. Changes have been occurring in satellite positioning systems due to the addition of new signals in GPS (Global System Positioning), restructuring of GLONASS (Global Orbiting Navigation Satellite System), and the new systems like Galileo and Compass as well. To evaluate the effects of combining GPS and GLONASS data, several batches of processings were performed on different configurations. The data processing was performed to determine the coordinates of points of basic support and those materializing the neighborhood of the rural properties. As a result, it was found that the use of accurate ephemeris in transporting coordinates to support points has no significant influence, since transportation with broadcast ephemeris also meets the accuracy requirements for the Standard Technique for Georreferencing Rural Properties. On the other hand, when GPS and GLONASS data were used, such combination provides the best results. In the case of neighboring points, the use of GPS and GLONASS data is also recommended because such data meet the precision requirement and showed better results than those from where data were processed separately.
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Objectives: The incretin-based therapy might be effective in patients possessing certain levels of preserved pancreatic beta-cells. However, doubts still exist regarding the efficacy of this atment in the recovery of tissues damaged by type 1 diabetes. Thus, the objective of this study was to evaluate the treatment with MK0431 in salivary glands of spontaneously diabetic mice, focusing mainly on the possible therapeutic and hypoglycaemic effects of this dipeptidyl peptidase IV inhibitor in the recovery of these salivary tissues. Methods and results: Twenty mice were divided into two groups of 10 animals each: group I (NOD diabetic/untreated) and group II (NOD diabetic MK0431/treated). The group II was treated during 4 weeks with MK0431 mixed in the food. The group I was maintained in the same way without receiving, however, any treatment. Glucose levels were monitored during treatment and salivary glands samples were collected at the end of treatment for the histological examination under both transmitted and polarized light microscopy. High glucose levels were observed in untreated animals, while in animals with treatment, reduction of these levels was observed. Tissue restructuring was also observed in animals submitted to therapy with MK0431, mainly in relation to the attempt to extracellular matrix reorganization. Conclusions: According to results, the treatment with this dipeptidyl peptidase IV inhibitor contributed to the general homeostasis of the organism and to the reestablishment of both epithelial and stromal compartments which were damaged by the hyperglycaemic condition, demonstrating that the incretin-based therapy may be an important complementary treatment for the type 1 diabetic condition. © 2012 Elsevier Ltd.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)