Cloning and Characterization of peter pan, a Novel Drosophila Gene Required for Larval Growth

We identified a new Drosophila gene, peter pan (ppan), in a screen for larval growth–defective mutants. ppan mutant larvae do not grow and show minimal DNA replication but can survive until well after their heterozygotic siblings have pupariated. We cloned the ppan gene by P-element plasmid rescue. ppan belongs to a highly conserved gene family that includes Saccharomyces cerevisiae SSF1 and SSF2, as well as Schizosaccharomyces pombe, Arabidopsis, Caenorhabditis elegans, mouse, and human homologues. Deletion of both SSF1 and SSF2 in yeast is lethal, and depletion of the gene products causes cell division arrest. Mosaic analysis of ppan mutant clones in Drosophila imaginal disks and ovaries demonstrates that ppan is cell autonomous and required for normal mitotic growth but is not absolutely required for general biosynthesis or DNA replication. Overexpression of the wild-type gene causes cell death and disrupts the normal development of adult structures. The ppan gene family appears to have an essential and evolutionarily conserved role in cell growth.

As idéias de Peter Haberle e a abertura da interpretação constitucional no Direito brasileiro

Na RDA há pequena variação no título

Konrad Hesse / Peter Haberle : um retorno aos fatores reais do poder

Inclui notas bibliográficas

Os limites da política comercial da comunidade européia / Peter Gilsdort. --

Palestra realizada em 12.02.88 no Instituto Europeu da Universidade do Sarre, República Federal da Alemanha.

Payment order for Peter Whitney, 1791 July 4

Handwritten order to John Sale to pay scholarship funds to Peter Whitney for use by his son, signed by John Clarke, David Tilden, and James Morrill.

Large Upper Devonian arthrodires from Iran / Hans-Peter Schultze --

v.23:no.5(1973)