792 resultados para Peer-to-Peer networks


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Peer reviewed

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The increasing interest aroused by more advanced forecasting techniques, together with the requirement for more accurate forecasts of tourismdemand at the destination level due to the constant growth of world tourism, has lead us to evaluate the forecasting performance of neural modelling relative to that of time seriesmethods at a regional level. Seasonality and volatility are important features of tourism data, which makes it a particularly favourable context in which to compare the forecasting performance of linear models to that of nonlinear alternative approaches. Pre-processed official statistical data of overnight stays and tourist arrivals fromall the different countries of origin to Catalonia from 2001 to 2009 is used in the study. When comparing the forecasting accuracy of the different techniques for different time horizons, autoregressive integrated moving average models outperform self-exciting threshold autoregressions and artificial neural network models, especially for shorter horizons. These results suggest that the there is a trade-off between the degree of pre-processing and the accuracy of the forecasts obtained with neural networks, which are more suitable in the presence of nonlinearity in the data. In spite of the significant differences between countries, which can be explained by different patterns of consumer behaviour,we also find that forecasts of tourist arrivals aremore accurate than forecasts of overnight stays.

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Les approches multimodales dans l'imagerie crbrale non invasive sont de plus en plus considres comme un outil indispensable pour la comprhension des diffrents aspects de la structure et de la fonction crbrale. Grce aux progrs des techniques d'acquisition des images de Resonance Magnetique et aux nouveaux outils pour le traitement des donnes, il est dsormais possible de mesurer plusieurs paramtres sensibles aux diffrentes caractristiques des tissues crbraux. Ces progrs permettent, par exemple, d'tudier les substrats anatomiques qui sont la base des processus cognitifs ou de discerner au niveau purement structurel les phnomnes dgnratifs et dveloppementaux. Cette thse met en vidence l'importance de l'utilisation d'une approche multimodale pour tudier les diffrents aspects de la dynamique crbrale grce l'application de cette approche deux tudes cliniques: l'valuation structurelle et fonctionnelle des effets aigus du cannabis fum chez des consommateurs rguliers et occasionnels, et l'valuation de l'intgrit de la substance grise et blanche chez des jeunes porteurs de la prmutations du gne FMR1 risque de dvelopper le FXTAS (Fragile-X Tremor Ataxia Syndrome). Nous avons montr que chez les fumeurs occasionnels de cannabis, mme faible concentration du principal composant psychoactif (THC) dans le sang, la performance lors d'une tche visuo-motrice est fortement diminue, et qu'il y a des changements dans l'activit des trois rseaux crbraux impliqus dans les processus cognitifs: le rseau de saillance, le rseau du contrle excutif, et le rseau actif par dfaut (Default Mode). Les sujets ne sont pas en mesure de saisir les saillances dans l'environnement et de focaliser leur attention sur la tche. L'augmentation de la rponse hmodynamique dans le cortex cingulaire antrieur suggre une augmentation de l'activit introspective. Une investigation des effets au niveau crbral d'une exposition prolonge au cannabis, montre des changements persistants de la substance grise dans les rgions associes la mmoire et au traitement des motions. Le niveau d'atrophie dans ces structures corrle avec la consommation de cannabis au cours des trois mois prcdant l'tude. Dans la deuxime tude, nous dmontrons des altrations structurelles des dcennies avant l'apparition du syndrome FXTAS chez des sujets jeunes, asymptomatiques, et porteurs de la prmutation du gne FMR1. Les modifications trouves peuvent tre lies deux mcanismes diffrents. Les altrations dans le rseau moteur du cervelet et dans la fimbria de l'hippocampe, suggrent un effet dveloppemental de la prmutation. Elles incluent aussi une atrophie de la substance grise du lobule VI du cervelet et l'altration des proprits tissulaires de la substance blanche des projections affrentes correspondantes aux pdoncules crbelleux moyens. Les lsions diffuses de la substance blanche crbrale peuvent tre un marquer prcoce du dveloppement de la maladie, car elles sont lies un phnomne dgnratif qui prcde l'apparition des symptmes du FXTAS. - Multimodal brain imaging is becoming a leading tool for understanding different aspects of brain structure and function. Thanks to the advances in Magnetic Resonance imaging (MRI) acquisition schemes and data processing techniques, it is now possible to measure different parameters sensitive to different tissue characteristics. This allows for example to investigate anatomical substrates underlying cognitive processing, or to disentangle, at a pure structural level degeneration and developmental processes. This thesis highlights the importance of using a multimodal approach for investigating different aspects of brain dynamics by applying this approach to two clinical studies: functional and structural assessment of the acute effects of cannabis smoking in regular and occasional users, and grey and white matter assessment in young FMR1 premutation carriers at risk of developing FXTAS. We demonstrate that in occasional smokers cannabis smoking, even at low concentration of the main psychoactive component (THC) in the blood, strongly decrease subjects' performance on a visuo-motor tracking task, and globally alters the activity of the three brain networks involved in cognitive processing: the Salience, the Control Executive, and the Default Mode networks. Subjects are unable to capture saliences in the environment and to orient attention to the task; the increase in Hemodynamic Response in the Anterior Cingulate Cortex suggests an increase in self-oriented mental activity. A further investigation on long term exposure to cannabis, shows a persistent grey matter modification in brain regions associated with memory and affective processing. The degree of atrophy in these structures also correlates with the estimation of drug use in the three months prior the participation to the study. In the second study we demonstrate structural changes in young asymptomatic premutation carriers decades before the onset of FXTAS that might be related to two different mechanisms. Alteration of the cerebellar motor network and of the hippocampal fimbria/ fornix, may reflect a potential neurodevelopmental effect of the premutation. These include grey matter atrophy in lobule VI and modification of white matter tissue property in the corresponding afferent projections through the Middle Cerebellar Peduncles. Diffuse hemispheric white matter lesions that seem to appear closer to the onset of FXTAS and be related to a neurodegenerative phenomenon may mark the imminent onset of FXTAS.

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The parameter setting of a differential evolution algorithm must meet several requirements: efficiency, effectiveness, and reliability. Problems vary. The solution of a particular problem can be represented in different ways. An algorithm most efficient in dealing with a particular representation may be less efficient in dealing with other representations. The development of differential evolution-based methods contributes substantially to research on evolutionary computing and global optimization in general. The objective of this study is to investigatethe differential evolution algorithm, the intelligent adjustment of its controlparameters, and its application. In the thesis, the differential evolution algorithm is first examined using different parameter settings and test functions. Fuzzy control is then employed to make control parameters adaptive based on an optimization process and expert knowledge. The developed algorithms are applied to training radial basis function networks for function approximation with possible variables including centers, widths, and weights of basis functions and both having control parameters kept fixed and adjusted by fuzzy controller. After the influence of control variables on the performance of the differential evolution algorithm was explored, an adaptive version of the differential evolution algorithm was developed and the differential evolution-based radial basis function network training approaches were proposed. Experimental results showed that the performance of the differential evolution algorithm is sensitive to parameter setting, and the best setting was found to be problem dependent. The fuzzy adaptive differential evolution algorithm releases the user load of parameter setting and performs better than those using all fixedparameters. Differential evolution-based approaches are effective for training Gaussian radial basis function networks.

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Wireless Sensor Networks (WSN) are formed by nodes with limited computational and power resources. WSNs are finding an increasing number of applications, both civilian and military, most of which require security for the sensed data being collected by the base station from remote sensor nodes. In addition, when many sensor nodes transmit to the base station, the implosion problem arises. Providing security measures and implosion-resistance in a resource-limited environment is a real challenge. This article reviews the aggregation strategies proposed in the literature to handle the bandwidth and security problems related to many-to-one transmission in WSNs. Recent contributions to secure lossless many-to-one communication developed by the authors in the context of several Spanish-funded projects are surveyed. Ongoing work on the secure lossy many-to-one communication is also sketched.

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This paper aims to better understand the development of students learning processes when participating actively in a specific Computer Supported Collaborative Learning system called KnowCat. To this end, a longitudinal case study was designed, in which eighteen university students took part in a 12-month (two semesters) learning project. During this time period, the students followed an instructional process, using some elements of KnowCat (KnowCat key features) design to support and improve their interaction processes, especially peer learning processes. Our research involved both supervising the students collaborative learning processes throughout the learning project and focusing our analysis on the qualitative evolution of the students interaction processes and on the development of metacognitive learning processes. The results of the current research reveal that the instructional application of the CSCL-KnowCat system may favour and improve the development of the students metacognitive learning processes. Additionally, the implications of the design of computer supported collaborative learning networks and pedagogical issues are discussed in this paper.

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This paper presents the qualitative data collection process aimed at the study of the impactsocial relations and networks have on educational paths of immigrant students. In theframework of a R & D longitudinal study funded by the Ministry of Science and Innovation(2012-2014), the research team tracked the path of 87 immigrant students, from whom only 17successfully achieved the transition through the first and second year of Post-16 Education.A vast range of literature notes that relationships are an important part of migration process andsocial integration analysis, as well as school history in terms of success or failure. Through thefieldwork researchers collect the personal networks of all immigrant students from 3 highschools who were at that time attending last course of compulsory school. The network structureinfluences their social capital and therefore determines the resources, goods and types of supportindividuals can access. All these aspects are influential elements in the configuration anddevelopment of academic trajectories of immigrant students.At the end of the second year of Post-16 Education (two years later), the study captures personalnetworks of these students again, analyses and discusses their evolution and influence on theirpaths through qualitative interviews. Such interviews facilitated the discussion of theirrelationships while providing interesting narratives that are presented in the text. In order to do so, the biographical interpretive narrative method of interviewing is implemented.

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This paper presents the qualitative data collection process aimed at the study of the impactsocial relations and networks have on educational paths of immigrant students. In theframework of a R & D longitudinal study funded by the Ministry of Science and Innovation(2012-2014), the research team tracked the path of 87 immigrant students, from whom only 17successfully achieved the transition through the first and second year of Post-16 Education.A vast range of literature notes that relationships are an important part of migration process andsocial integration analysis, as well as school history in terms of success or failure. Through thefieldwork researchers collect the personal networks of all immigrant students from 3 highschools who were at that time attending last course of compulsory school. The network structureinfluences their social capital and therefore determines the resources, goods and types of supportindividuals can access. All these aspects are influential elements in the configuration anddevelopment of academic trajectories of immigrant students.At the end of the second year of Post-16 Education (two years later), the study captures personalnetworks of these students again, analyses and discusses their evolution and influence on theirpaths through qualitative interviews. Such interviews facilitated the discussion of theirrelationships while providing interesting narratives that are presented in the text. In order to do so, the biographical interpretive narrative method of interviewing is implemented.

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Rare diseases are typically chronic medical conditions of genetic etiology characterized by low prevalence and high complexity. Patients living with rare diseases face numerous physical, psychosocial and economic challenges that place them in the realm of health disparities. Congenital hypogonadotropic hypogonadism (CHH) is a rare endocrine disorder characterized by absent puberty and infertility. Little is known about the psychosocial impact of CHH on patients or their adherence to available treatments. This project aimed to examine the relationship between illness perceptions, depressive symptoms and adherence to treatment in men with CHH using the nursing-sensitive Health Promotion Model (HPM). A community based participatory research (CBPR) framework was employed as a model for empowering patients and overcoming health inequities. The study design used a sequential, explanatory mixed-methods approach. To reach dispersed CHH men, we used web-based recruitment and data collection (online survey). Subsequently, three patient focus groups were conducted to provide explanatory insights into the online survey (i.e. barriers to adherence, challenges of CHH, and coping/support) The online survey (n=101) revealed that CHH men struggle with adherence and often have long gaps in care (40% >1 year). They experience negative psychosocial consequences because of CHH and exhibit significantly increased rates of depression (p<0.001). Focus group participants (n=26) identified healthcare system, interpersonal, and personal factors as barriers to adherence. Further, CHH impacts quality of life and impedes psychosexual development in these men. The CHH men are active internet users who rely on the web forcrowdsourcing solutions and peer-to-peer support. Moreover, they are receptive to web-based interventions to address unmet health needs. This thesis contributes to nursing knowledge in several ways. First, it demonstrates the utility of the HPM as a valuable theoretical construct for understanding medication adherence and for assessing rare disease patients. Second, these data identify a range of unmet health needs that are targets for patient-centered interventions. Third, leveraging technology (high-tech) effectively extended the reach of nursing care while the CBPR approach and focus groups (high-touch) served as concurrent nursing interventions facilitating patient empowerment in overcoming health disparities. Last, these findings hold promise for developing e-health interventions to bridge identified shortfalls in care and activating patients for enhanced self- care and wellness -- Les maladies rares sont gnralement de maladies chroniques d'tiologie gntique caractrises par une faible prvalence et une haute complexit de traitement. Les patients atteints de maladies rares sont confronts de nombreux dfis physiques, psychosociaux et conomiques qui les placent dans une posture de disparit et d'ingalits en sant. L'hypogonadisme hypogonadotrope congnital (CHH) est un trouble endocrinien rare caractris par l'absence de pubert et l'infertilit. On sait peu de choses sur l'impact psychosocial du CHH sur les patients ou leur adhsion aux traitements disponibles. Ce projet vise examiner la relation entre la perception de la maladie, les symptmes dpressifs et l'observance du traitement chez les hommes souffrant de CHH. Cette tude est modlise l'aide du modle de la Promotion de la sant de Pender (HPM). Le cadre de l'approche communautaire de recherche participative (CBPR) a aussi t utilis. La conception de l'tude a repos sur une approche mixte squentielle. Pour atteindre les hommes souffrant de CHH, un recrutement et une collecte de donnes ont t organises lectroniquement. Par la suite, trois groupes de discussion ont t menes avec des patients experts impliqus au sein d'organisations relis aux maladies rares. Ils ont t invits discuter certains lments additionnels dont, les obstacles l'adhsion au traitement, les dfis gnraux de vivre avec un CHH, et l'adaptation la maladie en tenant compte du soutien disponible. Le sondage en ligne (n = 101) a rvl que les hommes souffrant de CHH ont souvent de longues priodes en rupture de soins (40% > 1 an). Ils vivent des consquences psychosociales ngatives en raison du CHH et prsentent une augmentation significative des taux de dpression (p <0,001). Les participants aux groupes de discussion (n = 26) identifient dans l'ordre, les systmes de soins de sant, les relations interpersonnelles, et des facteurs personnels comme des obstacles l'adhsion. En outre, selon les participants, le CHH impacte ngativement sur leur qualit de vie gnrale et entrave leur dveloppement psychosexuel. Les hommes souffrant de CHH se considrent tre des utilisateurs actifs d'internet et comptent sur le web pour trouver des solutions pour trouver des ressources et y recherchent le soutien de leurs pairs (peer-to-peer support). En outre, ils se disent rceptifs des interventions qui sont bases sur le web pour rpondre aux besoins de sant non satisfaits. Cette thse contribue la connaissance des soins infirmiers de plusieurs faons. Tout d'abord, elle dmontre l'utilit de la HPM comme une construction thorique utile pour comprendre l'adhsion aux traitements et pour l'valuation des lments de promotion de sant qui concernent les patients atteints de maladies rares. Deuximement, ces donnes identifient une gamme de besoins de sant non satisfaits qui sont des cibles pour des interventions infirmires centres sur le patient. Troisimement, mthodologiquement parlant, cette tude dmontre que les mthodes mixtes sont appropries aux tudes en soins infirmiers car elles allient les nouvelles technologies qui peuvent effectivement tendre la porte des soins infirmiers ( high-tech ), et l'approche CBPR par des groupes de discussion ( high-touch ) qui ont facilit la comprhension des difficults que doivent surmonter les hommes souffrant de CHH pour diminuer les disparits en sant et augmenter leur responsabilisation dans la gestion de la maladie rare. Enfin, ces rsultats sont prometteurs pour dvelopper des interventions e-sant susceptibles de combler les lacunes dans les soins et l'autonomisation de patients pour une meilleure emprise sur les auto-soins et le bien-tre.

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Polyphenols are a major class of bioactive phytochemicals whose consumption may play a role in the prevention of a number of chronic diseases such as cardiovascular diseases, type II diabetes and cancers. Phenol-Explorer, launched in 2009, is the only freely available web-based database on the content of polyphenols in food and their in vivo metabolism and pharmacokinetics. Here we report the third release of the database (Phenol-Explorer 3.0), which adds data on the effects of food processing on polyphenol contents in foods. Data on >100 foods, covering 161 polyphenols or groups of polyphenols before and after processing, were collected from 129 peer-reviewed publications and entered into new tables linked to the existing relational design. The effect of processing on polyphenol content is expressed in the form of retention factor coefficients, or the proportion of a given polyphenol retained after processing, adjusted for change in water content. The result is the first database on the effects of food processing on polyphenol content and, following the model initially defined for Phenol-Explorer, all data may be traced back to original sources. The new update will allow polyphenol scientists to more accurately estimate polyphenol exposure from dietary surveys. Database URL: http://www.phenol-explorer.eu

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Yrittjyyden Tuki - projekti toimi osana valtakunnallista WomEqual - kehittmiskumppanuushanketta vuosina 2005-2007 tavoitteenaan tukea naisyrittjien toimintaedellytyksi kehitten heille vertaisryhmtoimintaan perustuvaa tukimallia. Tss tutkimuksessa ensisijaisena tavoitteena on selvitt, miten kyseisen projektin vertaisryhmtoimintaan osallistuneet naisyrittjt kokivat naisyrittjien vlisen vertaistuen toimintamuotona. Pyrkimyksen on mys ymmrt, mitk seikat sitouttivat naisyrittji vertaisryhmtoimintaan ja mit he kokivat oppineensa vertaisryhmtoiminnan seurauksena. Lisksi kiinnostuksen kohteena on tarkastella, kuinka vertaistukiryhm toimii naisyrittjien vlisen verkostoitumisen vlineen. Tutkimus on laadullinen ja aineistolhtinen. Tutkimuksen primriaineisto on kertty puolistrukturoiduin teemahaastatteluilla ja sekundaariaineisto kyselytutkimuksen avulla. Tutkimustulokset osoittavat, ett naisyrittjt kokevat henkisen ja sosiaalisen tuen trkeksi. Toiselta naisyrittjlt, vertaiselta, saatu tuki koettiin vertaistukiryhmn vahvuudeksi. Vertaisryhmss oppiminen tapahtui kokemusten jakamisen kautta. Uusien verkostojen luomisessa vertaistukiryhm ei tysin vastannut odotuksia.

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The objective of this thesis is to provide a business model framework that connects customer value to firm resources and explains the change logic of the business model. Strategic supply management and especially dynamic value network management as its scope, the dissertation is based on basic economic theories, transaction cost economics and the resource-based view. The main research question is how the changing customer values should be taken into account when planning business in a networked environment. The main question is divided into questions that form the basic research problems for the separate case studies presented in the five Publications. This research adopts the case study strategy, and the constructive research approach within it. The material consists of data from several Delphi panels and expert workshops, software pilot documents, company financial statements and information on investor relations on the companies web sites. The cases used in this study are a mobile multi-player game value network, smart phone and Skype mobile services, the business models of AOL, eBay, Google, Amazon and a telecom operator, a virtual city portal business system and a multi-play offering. The main contribution of this dissertation is bridging the gap between firm resources and customer value. This has been done by theorizing the business model concept and connecting it to both the resource-based view and customer value. This thesis contributes to the resource-based view, which deals with customer value and firm resources needed to deliver the value but has a gap in explaining how the customer value changes should be connected to the changes in key resources. This dissertation also provides tools and processes for analyzing the customer value preferences of ICT services, constructing and analyzing business models and business concept innovation and conducting resource analysis.

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MetaNetX is a repository of genome-scale metabolic networks (GSMNs) and biochemical pathways from a number of major resources imported into a common namespace of chemical compounds, reactions, cellular compartments-namely MNXref-and proteins. The MetaNetX.org website (http://www.metanetx.org/) provides access to these integrated data as well as a variety of tools that allow users to import their own GSMNs, map them to the MNXref reconciliation, and manipulate, compare, analyze, simulate (using flux balance analysis) and export the resulting GSMNs. MNXref and MetaNetX are regularly updated and freely available.

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JXTA is a mature set of open protocols, with morethan 10 years of history, that enable the creation and deployment of peer-to-peer (P2P) networks, allowing the execution of services in a distributed manner. Throughout its lifecycle, ithas slowly evolved in order to appeal a broad set of different applications. Part of this evolution includes providing basic security capabilities in its protocols in order to achieve some degree of message privacy and authentication. However, undersome contexts, more advanced security requirements should be met, such as anonymity. There are several methods to attain anonymity in generic P2P networks. In this paper, we proposehow to adapt a replicated message-based approach to JXTA, by taking advantage of its idiosyncracies and capabilities.