Tales of the drama. Founded on the tragedies of Shakspeare, Massinger, Shirley, Rowe, Murphy, Lillo, and Moore, and on the comedies of Steele, Farquhar, Cumberland, Bickerstaff, Goldsmith, and Mrs. Cowley.

Duke of Milan.--The inconstant.--The good-natured man.--Introduction to Shakespeare's plays.--King John.--The Quaker.--Edward the Black prince.--The belle's stratagem.--Winter's tale.--George Barnwell.--The conscious lovers.--King Richard II.--The Grecian daughter.--The brothers.--Lady Jane Grey.--The Merchant of Venice.--Coriolanus.--The way to keep him.--The gamester.--The hypocrite.--Julius Cæsar.--Conclusion.

The Carlyle collection. A catalogue of books on Oliver Cromwell and Frederick the Great, bequeathed by Thomas Carlyle to Harvard College Library.

Oliver Cromwell. A cast from the original mask taken after death ..." (plate facing p. [2])

Travels in Peru, during the years 1838-1842, on the coast, in the Sierra, across the Cordilleras and the Andes, into the primeval forests.

Paged continuously.

Report on manuscripts in various collections ...

v. 1. Berwick-upon-Tweed, Burford and Lostwithiel corporations; the counties of Wilts and Worcester; the Bishop of Chichester; and the deans and chapters of Chichester, Canterbury and Salisbury.--v. 2. Sir George Wombwell, the Duke of Norfolk, Lord Edmund Talbot, Miss Buxton, Mrs. Harford and Mrs. Wentworth of Woolley.--v. 3. T.B. Clarke-Thornhill, esq., Sir T. Barrett-Lennard, bart., Pelham R. Papillon, esq., and W. Cleverly Alexander, esq.--v. 4. Bishop of Salisbury; Bishop of Exeter, dean and chapter of Exeter; Earl of Leicester; Sir William Clayton, bart.; Major Money-Kyrle; F.H.T. Jervoise, esq.; Glemham hall; corporations of Salisbury, Orford and Aldeburgh.--v. 5. Col. Mordaunt-Hay, of Duns castle; Sir Archibald Edmonstone, of Duntreath; Sir John James Graham, of Fintry, K.C.M.G.--v. 6. Miss M. Eyre Matcham; Captain H.V. Knox; Cornwallis Wykeham-Martin, esq.; K.B. Tighe, esq.; Lord Oranmore and Brown.--v. 7. The Bishop of London; St. George's chapel, Windsor; diocese of Gloucester; corporations of Beccles, Dunwich, Southwold and Thetford; Duke of Norfolk; Earl of essex; Sir Hervey Bruce, Col. Frewen, H.C. Staunton, esq., and F. Merttens, esq.; S. Philip Unwin, esq.--v. 8. The Hon. Frederick Lindley Wood; M.L.S. Clements, esq.; S. Philip Unwin, esq.

Going to camp on the Au Sable & Northwest R.R.

On verso: A picnic for some visiting friends; Going to camp on the Au Sable & Northwestern RR. Henry Martyn Loud, Mary L. Gay, his daughter, Jim Tally, Edwin F. Gay, Edward F. Loud, Henry Nelson Loud, Mrs. Connine, Mrs. Greene Pack? or Grace Pack, Miss Marian Loud, Mrs. J.B. Tuttle, Edwin F. Holmes, Harriet Holmes, Helen Holmes, Olive Holmes, George A. Loud, Greene Pack, Jack Millen, Emerson Smith

Miss Martineau and her master /

"The work on which the following pages form a brief commentary, is entitled "Letters on the Laws of Man's Nature and Development." It consists of a correspondence between Miss Harriet Martineau and Mr. George Atkinson..."-pref.

Ereğli maden-i hümayun-ı sahilinde bir liman ile rıhtım inşasına ve imtiyazat saireye dair ihsan buyurulan fermanı âlisi ile mukavele ve şartnamesidir = Firman impérial convention et cahier des charges concernant la construction sur le rivage des mines d'Héraclée d'un port, des quais et autres privilèges accordés par Firman Impérial.

Convention signed on 27 june 1308 (1892) [i.e. 8 July 1892]

Historic names and places on the lower Mississippi River /

Includes index.

Wartime health and education : hearings before a subcommittee of the Committee on Education and Labor, United States Senate, Seventy-eighth Congress, first session, pursuant to S. Res. 74, a resolution authorizing an investigation of the educational and physical fitness of the civilian population as related to national defense.

Claude Pepper, chairman of subcommittee.

Celebrity, Nation, and the New Australian Woman: Tania Verstak, Miss Australia 1961

This article examines two women who signified the 'ideal' feminine for Australians and represented the Australian nation on the global stage: Beryl Mills, the first Miss Australia, crowned in 1926, and Tania Verstak, Miss Australia 1961. Both women gained celebrity through their role as Miss Australia, but Tania Verstak is of particular significance as the first 'new Australian' woman to win the coveted title. The strategy of viewing the two women as embodying the Australian nation reveals some of the dramatic social shifts that occurred in the Australian consciousness over the thirty-five years that separated the two title-holders; furthermore, it demonstrates how those shifts reshaped Australia's national identity and its feminine imagery.

Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT)

1 The aim was to test the hypothesis that nitric oxide ( NO) donor drugs can inhibit the 5-hydroxytryptamine (5-HT) transporter, SERT. 2 The NO donors, MAHMA/NO ( a NONOate; (Z)-1-[N-methyl-N-[6-(N-methylammoniohexyl)amino]]diazen- 1-ium-1,2-diolate), SIN-1 ( a sydnonimine; 5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride), FK409 ( an oxime; (+/-)-(4-ethyl-2E-(hydroxyimino)-5-nitro-3E-hexenamide)) and peroxynitrite, but not Angeli's salt ( source of nitroxyl anion) or sodium nitrite, caused concentration-dependent inhibition of the specific uptake of [H-3]- 5-HT in COS-7 cells expressing human SERT. 3 Superoxide dismutase (150 U ml(-1)) plus catalase ( 1200 U ml(-1)), used to remove superoxide and hence prevent peroxynitrite formation, prevented the inhibitory effect of SIN-1 ( which generates superoxide) but not of MAHMA/NO or FK409. 4 The inhibitory effects of the NO donors were not affected by the free radical scavenger, hydroxocobalamin (1 mM) or the guanylate cyclase inhibitor, ODQ (1H-[ 1,2,4] oxadiazolo[4,3-a] quinoxalin-1-one; 3 muM). 5 L-Cysteine ( 1 mM; source of excess thiol residues) abolished or markedly reduced the inhibitory effects of MAHMA/NO, SIN-1, FK409 and peroxynitrite. 6 It is concluded that inhibition of SERT by the NO donors cannot be attributed exclusively to NO free radical nor to nitroxyl anion. It does not involve guanosine-3',5'-cyclic monophosphate, but may involve nitrosation of cysteine residues on the SERT protein. Peroxynitrite mediates the effect of SIN-1, but not the other drugs. 7 Data in mice with hypoxic pulmonary hypertension suggest that SERT inhibitors may attenuate pulmonary vascular remodelling. Thus, NO donors may be useful in pulmonary hypertension, not only as vasodilators, but also because they inhibit SERT, provided they display this effect in vivo at appropriate doses.

The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts

Objectives:The aim of this study was to assess the biological rationale for the use of platelet-rich plasma (PRP) by evaluating the effect of different concentrations of PRP on osteoblasts (OB) and fibroblasts (FB) function in vitro. Materials and methods:PRP was obtained from volunteer donors using standard protocols. Primary human cultures of oral FBs and OBs were exposed to both activated and non-activated plasma as well as various concentrations of PRP (2.5 x, 3.5 x and max (4.2-5.5 x)). Cell proliferation was evaluated after 24 and 72 h using an MTT proliferation assay. Production of osteocalcin (OCN), osteoprotegerin (OPG) and transforming growth factor beta 1 (TGF-beta 1) was evaluated in OB after 24 and 72 h. Statistical analysis was performed using one-way ANOVA. Results:PRP-stimulated cell proliferation in both OBs and FBs. The effect of different PRP concentrations on cell proliferation was most notable at 72 h. The maximum effect was achieved with a concentration of 2.5 x, with higher concentrations resulting in a reduction of cell proliferation. Upregulation of OCN levels and downregulation of OPG levels were noted with increasing PRP concentrations at both 24 and 72 h. TGF-beta 1 levels were stimulated by increasing concentrations of PRP, with the increased levels being maintained at 72 h. Conclusions:PRP preparations exert a dose-specific effect on oral FBs and OBs. Optimal results were observed at a platelet concentration of 2.5 x, which was approximately half of the maximal concentrate that could be obtained. Increased concentrations resulted in a reduction in proliferation and a suboptimal effect on OB function. Hence, different PRP concentrations may have an impact on the results that can be obtained in vivo.

Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: comparative effects on pulmonary vascular structure and function

1 Hypoxic pulmonary hypertension in rats (10% O-2, 4 weeks) is characterized by changes in pulmonary vascular structure and function. The effects of the angiotensin converting enzyme inhibitor perindopril (oral gavage, once daily for the 4 weeks of hypoxia) on these changes were examined. 2 Perindopril (30 mg kg(-1) d(-1)) caused an 18% reduction in pulmonary artery pressure in hypoxic rats. 3 Structural changes (remodelling) in hypoxic rats included increases in (i) critical closing pressure in isolated perfused lungs (remodelling of arteries (50 mu m 0.d.) and (ii) medial wall thickness of intralobar pulmonary arteries, assessed histologically (vessels 30-100 and 101-500 mu m o.d.). Perindopril 10 and 30 mg kg(-1) d(-1) attenuated remodelling in vessels less than or equal to 100 mu m (lungs and histology), 30 mg kg(-1) d(-1) was effective in vessels 101-500 mu m but neither dose prevented hypertrophy of main pulmonary artery. 3 mg kg(-1) d(-1) was without effect. 4 Perindopril (30 mg kg(-1) d(-1)) prevented the exaggerated hypoxic pulmonary vasoconstrictor response seen in perfused lungs from hypoxic rats but did not prevent any of the functional changes (i.e. the increased contractions to 5-HT, U46619 (thromboxane-mimetic) and K+ and diminished contractions to angiotensins I and II) seen in isolated intralobar or main pulmonary arteries. Acetylcholine responses were unaltered in hypoxic rats. 5 We conclude that, in hypoxic rats, altered pulmonary vascular function is largely independent of remodelling. Hence any drug that affects only remodelling is unlikely to restore pulmonary vascular function to normal and, like perindopril, may have only a modest effect on pulmonary artery pressure.

Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells

We have studied the hypothesis that 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) is neurotoxic. Salsolinol induced a significant time and dose related inhibition of 3[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; thiazoyl blue (MTT) reduction, and increased lactate dehydrogenase release (LDH) release from human SH-SY5Y neuroblastoma cells, at concentrations within the range of 1-methyl-4-phenylpyridinium (MPP+) cytotoxicity, in vitro. Cytotoxicity was not inhibited by the addition of antioxidants, monoamine oxidase inhibitors or imipramine. In confluent monolayers, salsolinol stimulated catecholamine uptake with EC50 values of 17 muM and 11 muM, for noradrenaline and dopamine, respectively. Conversely, at concentrations above 100 muM, salsolinol inhibited the uptake of noradrenaline and dopamine, with IC50 values of 411 muM and 379 muM, respectively. The inhibition of catecholamine uptake corresponded to the increase displacement of [3H]nisoxetine from the uptake 1 site by salsolinol, as the Ki (353 muM) for displacement was similar to the IC50 (411 and 379 muM) for uptake. Salsolinol stimulated catecholamine uptake does not involve the uptake recognition site, or elevation of cAMP, cGMP, or inhibition of protein kinase C. Salsolinol also inhibited both carbachol (1 mM) and K+ (100 mM, Na+ adjusted) evoked released of noradrenaline from SH-SY5Y cells, with IC50 values of 500 muM and 120 muM, respectively. In conclusion, salsolinol appears to be cytotoxic to SH-SY5Y cells, via a mechanism that does not require uptake 1, bioactivation by monoamine oxidase, or membrane based free radical damage. The effects of salsolinol on catecholamine uptake, and the mechanism of toxicity require further investigation.

Nano-indentation measurement of oxide layers formed in LBE on F/M steels

Ferritic/martensitic (F/M) steels (T91, HT-9, EP 823) are candidate materials for future liquid lead or lead bismuth eutectic (LBE) cooled nuclear reactors. To understand the corrosion of these materials in LBE, samples of each material were exposed at 535 °C for 600 h and 200 h at an oxygen content of 10 wt%. After the corrosion tests, the samples were analyzed using SEM, WDX and nano-indentation in cross section. Multi-layered oxide scales were found on the sample surfaces. The compositions of these oxide layers are not entirely in agreement with the literature. The nano-indentation results showed that the E-modulus and hardness of the oxide layers are significantly lower than the values for dense bulk oxide materials. It is assumed that the low values stem from high porosity in the oxide layers. Comparison with in-air oxidized steels show that the E-modulus decreases with increasing oxide layer thickness. © 2008 Elsevier B.V. All rights reserved.