Agreed upon procedures report of the Protective Payee Program of Lee County as of February 15, 2007

Agreed upon procedures report of the Protective Payee Program of Lee County as of February 15, 2007

Audit report on Lee County, Iowa for the year ended June 30, 2007

Audit report on Lee County, Iowa for the year ended June 30, 2007

Catalogue d'une collection précieuse de tableaux et dessins des meilleurs maîtres des trois écoles, bronzes, marbres, terres cuites... dont la vente se fera... le lundi 15 et jours suivans du mois de mars 1779 . Par N. F. J. Boileau,...

[Vente (Art). 1779-03-15. Paris]

Audit report on Lee County, Iowa for the year ended June 30, 2008

Audit report on Lee County, Iowa for the year ended June 30, 2008

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.