Cognitive reserve benefits brain efficiency in healthy aging

The concept of cognitive reserve (CR) describes the mind’s resistance to the progressive damage of the brain and probably this can be reflected as the ability to recruit brain networks in an effective way. It is as- sociated with the abilityto copewith the deleterious effects of brain damage,brain degeneration, or age-related changes on cognitive performance.

Cognitive reserve is associated with the functional organization of brain networks in healthy aging: a MEG study

The proportion of elderly people in the population has increased rapidly in the last century and consequently "healthy aging" is expected to become a critical area of research in neuroscience. Evidence reveals how healthy aging depends on three main behavioral factors: social lifestyle, cognitive activity and physical activity. In this study, we focused on the role of cognitive activity, concentrating specifically on educational and occupational attainment factors, which were considered two of the main pillars of cognitive reserve. 21 subjects with similar rates of social lifestyle, physical and cognitive activity were selected from a sample of 55 healthy adults. These subjects were divided into two groups according to their level of cognitive reserve; one group comprised subjects with high cognitive reserve (9 members) and the other contained those with low cognitive reserve (12 members). To evaluate the cortical brain connectivity network, all participants were recorded by Magnetoencephalography (MEG) while they performed a memory task (modified version of the Sternberg¿s Task). We then applied two algorithms (Phase Locking Value & Phase-Lag Index) to study the dynamics of functional connectivity. In response to the same task, the subjects with lower cognitive reserve presented higher functional connectivity than those with higher cognitive reserve. These results may indicate that participants with low cognitive reserve needed a greater 'effort' than those with high cognitive reserve to achieve the same level of cognitive performance. Therefore, we conclude that cognitive reserve contributes to the modulation of the functional connectivity patterns of the aging brain.

TMS- EEG Signatures of GABAergic Neurotransmission in the Human Cortex

Combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) constitutes a powerful tool to directly assess human cortical excitability and connectivity. TMS of the primary motor cortex elicits a sequence of TMS-evoked EEG potentials (TEPs). It is thought that inhibitory neurotransmission through GABA-A receptors (GABAAR) modulates early TEPs (<50 ms after TMS), whereas GABA-B receptors (GABABR) play a role for later TEPs (at ∼100 ms after TMS). However, the physiological underpinnings of TEPs have not been clearly elucidated yet. Here, we studied the role of GABAA/B-ergic neurotransmission for TEPs in healthy subjects using a pharmaco-TMS-EEG approach. In Experiment 1, we tested the effects of a single oral dose of alprazolam (a classical benzodiazepine acting as allosteric-positive modulator at α1, α2, α3, and α5 subunit-containing GABAARs) and zolpidem (a positive modulator mainly at the α1 GABAAR) in a double-blind, placebo-controlled, crossover study. In Experiment 2, we tested the influence of baclofen (a GABABR agonist) and diazepam (a classical benzodiazepine) versus placebo on TEPs. Alprazolam and diazepam increased the amplitude of the negative potential at 45 ms after stimulation (N45) and decreased the negative component at 100 ms (N100), whereas zolpidem increased the N45 only. In contrast, baclofen specifically increased the N100 amplitude. These results provide strong evidence that the N45 represents activity of α1-subunit-containing GABAARs, whereas the N100 represents activity of GABABRs. Findings open a novel window of opportunity to study alteration of GABAA-/GABAB-related inhibition in disorders, such as epilepsy or schizophrenia.

MedVir: an interactive representation system of multidimensional medical data applied to Traumatic Brain Injury's rehabilitation prediction

Clinicians could model the brain injury of a patient through his brain activity. However, how this model is defined and how it changes when the patient is recovering are questions yet unanswered. In this paper, the use of MedVir framework is proposed with the aim of answering these questions. Based on complex data mining techniques, this provides not only the differentiation between TBI patients and control subjects (with a 72% of accuracy using 0.632 Bootstrap validation), but also the ability to detect whether a patient may recover or not, and all of that in a quick and easy way through a visualization technique which allows interaction.

A SENHORA DA BERLINDA Representações sociais do cotidiano na religiosidade popular paraense

O culto a Nossa Senhora de Nazaré é uma devoção popular muito antiga em Belém do Pará, quase tão antiga quanto a cidade, pois esse culto se consolidou na mesma época em que se constituiu o município de Belém e o Estado do Pará. A população de devotos cresceu junto com a população dos habitantes da cidade. Tal fato propiciou que essa devoção popular se enraizasse profundamente na cultura paraense, penetrando até a auto-imagem do paraense católico, moldando a sua identidade cultural. A maior expressão desse culto é a grande romaria que os devotos realizam todos os anos no mês de outubro, que é conhecida como Círio de Nazaré e reúne uma média de dois milhões de pessoas, aproximadamente. O Círio de 2002 foi o recorte etnológico dessa pesquisa que disserta sobre as práticas cotidianas dos devotos no seu culto a Nossa Senhora de Nazaré, sobre como a religiosidade popular insere-se no dia-a-dia dos indivíduos, influenciando as representações sociais e recebendo a influência delas também, em um processo dialético.(AU)

A SENHORA DA BERLINDA Representações sociais do cotidiano na religiosidade popular paraense

O culto a Nossa Senhora de Nazaré é uma devoção popular muito antiga em Belém do Pará, quase tão antiga quanto a cidade, pois esse culto se consolidou na mesma época em que se constituiu o município de Belém e o Estado do Pará. A população de devotos cresceu junto com a população dos habitantes da cidade. Tal fato propiciou que essa devoção popular se enraizasse profundamente na cultura paraense, penetrando até a auto-imagem do paraense católico, moldando a sua identidade cultural. A maior expressão desse culto é a grande romaria que os devotos realizam todos os anos no mês de outubro, que é conhecida como Círio de Nazaré e reúne uma média de dois milhões de pessoas, aproximadamente. O Círio de 2002 foi o recorte etnológico dessa pesquisa que disserta sobre as práticas cotidianas dos devotos no seu culto a Nossa Senhora de Nazaré, sobre como a religiosidade popular insere-se no dia-a-dia dos indivíduos, influenciando as representações sociais e recebendo a influência delas também, em um processo dialético.(AU)

A dinâmica demográfica na região do INTERREG Ibérico, no final do século XX

Doutoramento em Sociologia, especialidade de Demografia

Recursos hídricos superficiais vs subterrâneos na Várzea da Nazaré : implicações na qualidade da água

Tese de doutoramento, Geologia (Hidrogeologia), Universidade de Lisboa, Faculdade de Ciências, 2016

Leaching and selected hydraulic properties of processed oil shales /

Mode of access: Internet.

Doct. Francisci Suarez Granatensis, ex Societate Iesu, Tractatus theologicus, de vera intelligentia auxilii efficacis, eiúque concordia, cum libero arbitrio : opys posthumum, ad stabiliendas definitiones fidei, à S.D.N. Innocentio X. contra Iansenium eiéusque partiarios, editas, accommodatum : prodit nunc primum.

Errors in pagination: nos. 201, 265-266, and 414 numbered respectively 191, 267-268, and 408; nos. 276-277 omitted.

Religious communism : a lecture by F.W. Evans (Shaker) of Mount Lebanon, Columbia Co., New York, U.S.A. : delivered in St. George's Hall, London, Sunday evening, August 6th, 1871 : with introductory remarks by the chairman of the meeting, Mr. Hepworth Dixon : also some account of the extent of the Shaker communities, and a narrative of the visit of Elder Evans to England ; an abstract of a lecture by Rev. J.M. Peebles, and his testimony in regard to the Shakers.

"Can any good come out of Nazareth? Abstract of J. M. Peeble's lecture on Sunday evening, July 30, in Cleveland Hall, London.": p. 30-32.

L'expédition d'Egypte /

On added t.p.: Septième série.--Format in-80 cavalier ill.