The animal kingdom arranged in conformity with its organization / by the Baron Cuvier ; the Crustacea, Arachnides and Insecta, by P.A. Latreille ; translated from the French, with notes and additions, by H. M'Murtrie ; in four volumes, with plates.

v 3 (1831)

The animal kingdom arranged in conformity with its organization / by the Baron Cuvier ; the Crustacea, Arachnides and Insecta, by P.A. Latreille ; translated from the French, with notes and additions, by H. M'Murtrie ; in four volumes, with plates.

v 2 (1831)

"Morphologic, genetic, and biochemical characterisation of novel Heliobacter isolates from laboratory mice and tigers"

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2012

The animal kingdom arranged in conformity with its organization / by the Baron Cuvier ; the Crustacea, Arachnides and Insecta, by P.A. Latreille ; translated from the French, with notes and additions, by H. M'Murtrie ; in four volumes, with plates.

v 1 (1831)

Protease-activated receptor (PAR)-1 and PAR-2 protect rat astrocytes from apoptotic cell death via differentially regulating JNK isoform-specific release of the chemokine GRO/CINC-1 : two novel protective pathways in brain

Protease-activated receptor; c-Jun N-terminal kinase (JNK); thrombin; neuroprotection; siRNA

search for a novel diagnostic marker or therapeutic target for gastrointestinal cancer

Gastrointestinal cancers, HCC, ectopeptidases, differential display, gasdermin-like

Function and regulation of death-associated protein kinase1 (DAPK) in colon cancer cells and macrophage-like cell line : identifcation of p38 as a novel DAPK interacting partner during TNFα-mediated apoptosis in colon cancer

DAPK, Apoptosis, p38, macrophages, survival

Screening for Fabry Disease in Left Ventricular Hypertrophy: Documentation of a Novel Mutation

AbstractBackground:Fabry disease is a lysosomal storage disease caused by enzyme α-galactosidase A deficiency as a result of mutations in the GLA gene. Cardiac involvement is characterized by progressive left ventricular hypertrophy.Objective:To estimate the prevalence of Fabry disease in a population with left ventricular hypertrophy.Methods:The patients were assessed for the presence of left ventricular hypertrophy defined as a left ventricular mass index ≥ 96 g/m2 for women or ≥ 116 g/m2 for men. Severe aortic stenosis and arterial hypertension with mild left ventricular hypertrophy were exclusion criteria. All patients included were assessed for enzyme α-galactosidase A activity using dry spot testing. Genetic study was performed whenever the enzyme activity was decreased.Results:A total of 47 patients with a mean left ventricular mass index of 141.1 g/m2 (± 28.5; 99.2 to 228.5 g/m2] were included. Most of the patients were females (51.1%). Nine (19.1%) showed decreased α-galactosidase A activity, but only one positive genetic test − [GLA] c.785G>T; p.W262L (exon 5), a mutation not previously described in the literature. This clinical investigation was able to establish the association between the mutation and the clinical presentation.Conclusion:In a population of patients with left ventricular hypertrophy, we documented a Fabry disease prevalence of 2.1%. This novel case was defined in the sequence of a mutation of unknown meaning in the GLA gene with further pathogenicity study. Thus, this study permitted the definition of a novel causal mutation for Fabry disease - [GLA] c.785G>T; p.W262L (exon 5).

A Novel Algorithm to Quantify Coronary Remodeling Using Inferred Normal Dimensions

Background:Vascular remodeling, the dynamic dimensional change in face of stress, can assume different directions as well as magnitudes in atherosclerotic disease. Classical measurements rely on reference to segments at a distance, risking inappropriate comparison between dislike vessel portions.Objective:to explore a new method for quantifying vessel remodeling, based on the comparison between a given target segment and its inferred normal dimensions.Methods:Geometric parameters and plaque composition were determined in 67 patients using three-vessel intravascular ultrasound with virtual histology (IVUS-VH). Coronary vessel remodeling at cross-section (n = 27.639) and lesion (n = 618) levels was assessed using classical metrics and a novel analytic algorithm based on the fractional vessel remodeling index (FVRI), which quantifies the total change in arterial wall dimensions related to the estimated normal dimension of the vessel. A prediction model was built to estimate the normal dimension of the vessel for calculation of FVRI.Results:According to the new algorithm, “Ectatic” remodeling pattern was least common, “Complete compensatory” remodeling was present in approximately half of the instances, and “Negative” and “Incomplete compensatory” remodeling types were detected in the remaining. Compared to a traditional diagnostic scheme, FVRI-based classification seemed to better discriminate plaque composition by IVUS-VH.Conclusion:Quantitative assessment of coronary remodeling using target segment dimensions offers a promising approach to evaluate the vessel response to plaque growth/regression.

Preparative chromatographic separation of ternary mixtures : analysis of fractionation times and novel concepts

Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2010

novel reactive distillation process for the production of cyclohexanol from cyclohexene

Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2010

Imaging beyond structure : novel noninvasive tools for neuroimaging of stem cell function and differentiation

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2013