Examining partner experience in cross-sector collaborative projects focused on the commercialization of R & D

The paper reports key findings from a four year study of cross-sector collaborative R&D projects in Australia testing a theoretical model formulated to explain partner collaboration experience and perceived project success. The study contributes to the understanding of knowledge-intensive collaborations, and indicates how their benefits can be sustained under conditions of high uncertainty. The study was of cross-sector collaborative projects within the Australian Cooperative Research Centre (CRC) Program which involved multiple partners and which were focused on the commercialization of R&D. The model was empirically tested through a survey of project leaders and the results provided support for the three main effects hypothesized. The theoretical, methodological and practical implications of the study's findings for the field of interorganizational relations (IOR) are discussed, and a new construct of project management competence is proposed as a determinant of positive partner experiences at the project level. This study adds to the growing body of work on interorganizational collaborative arrangements by providing systematic empirical support for a theoretical model of cross-sector R&D collaboration at the project level and at the completion or near completion phase of project development.

Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

Glycogen availability can influence glucose transporter 4 (GLUT4) expression in skeletal muscle through unknown mechanisms. The multisubstrate enzyme AMP-activated protein kinase (AMPK) has also been shown to play an important role in the regulation of GLUT4 expression in skeletal muscle. During contraction, AMPK [alpha]2 translocates to the nucleus and the activity of this AMPK isoform is enhanced when skeletal muscle glycogen is low. In this study, we investigated if decreased pre-exercise muscle glycogen levels and increased AMPK [alpha]2 activity reduced the association of AMPK with glycogen and increased AMPK [alpha]2 translocation to the nucleus and GLUT4 mRNA expression following exercise. Seven males performed 60 min of exercise at ~70% [VO.sub.2] peak on 2 occasions: either with normal (control) or low (LG) carbohydrate pre-exercise muscle glycogen content. Muscle samples were obtained by needle biopsy before and after exercise. Low muscle glycogen was associated with elevated AMPK [alpha]2 activity and acetyl-CoA carboxylase [beta] phosphorylation, increased translocation of AMPK [alpha]2 to the nucleus, and increased GLUT4 mRNA. Transfection of primary human myotubes with a constitutively active AMPK adenovirus also stimulated GLUT4 mRNA, providing direct evidence of a role of AMPK in regulating GLUT4 expression. We suggest that increased activation of AMPK [alpha]2 under conditions of low muscle glycogen enhances AMPK [alpha]2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle.

The TrueBlue study : is practice nurse-led collaborative care effective in the management of depression for patients with heart disease or diabetes?

Background: In the presence of type 2 diabetes (T2DM) or coronary heart disease (CHD), depression is under diagnosed and under treated despite being associated with worse clinical outcomes. Our earlier pilot study demonstrated that it was feasible, acceptable and affordable for practice nurses to extend their role to include screening for and monitoring of depression alongside biological and lifestyle risk factors. The current study will compare the clinical outcomes of our model of practice nurse-led collaborative care with usual care for patients with depression and T2DM or CHD.

Methods: This is a cluster-randomised intervention trial. Eighteen general practices from regional and metropolitan areas agreed to join this study, and were allocated randomly to an intervention or control group. We aim to recruit 50 patients with co-morbid depression and diabetes or heart disease from each of these practices. In the intervention group, practice nurses (PNs) will be trained for their enhanced roles in this nurse-led collaborative care study. Patients will be invited to attend a practice nurse consultation every 3 months prior to seeing their usual general practitioner. The PN will assess psychological, physiological and lifestyle parameters then work with the patient to set management goals. The outcome of this assessment will form the basis of a GP Management Plan document. In the control group, the patients will continue to receive their usual care for the first six months of the study before the PNs undergo the training and switch to the intervention protocol. The primary clinical outcome will be a reduction in the depression score. The study will also measure the impact on physiological measures, quality of life and on patient attitude to health care delivered by practice nurses.

Conclusion: The strength of this programme is that it provides a sustainable model of chronic disease management with monitoring and self-management assistance for physiological, lifestyle and psychological risk factors for high-risk patients with co-morbid depression, diabetes or heart disease. The study will demonstrate whether nurse-led collaborative care achieves better outcomes than usual care.

Creating collaborative spaces : the pleasures and perils of doing multi-disciplinary, multi-partner qualitative research

This paper describes our experience of managing a two-year research project that involved University staff from two different disciplines and three industry partners. It describes the benefits we gained from the involvement of multiple parties, such as the ability to call upon diverse expertise, the capacity to study a complex issue and the ability to make a direct contribution to industry practice. It also describes some of the difficulties such as managing across University structures, maintaining the collaborators' interest in the project, gaining approval from multiple ethics committees and managing the expectations of various stakeholders. The paper concludes with a number of recommendations for senior University staff and for researchers and points to ways universities could better facilitate involvement in these types of complex research projects.

Collaborative research training : a global challenge

Research training for postgraduate research students has entered a new era as the training process becomes a multi-dimensional practice, involving not just research students and supervisors from universities but also other stakeholders such as industry, funding agents, government, and in some cases, international stakeholders. Such a transition has created some challenges but also exciting opportunities. Centre for Material and Fibre Innovation (CMFI) at Deakin University, Australia has developed a number of innovative and effective paradigms on research training, producing high quality research scientists of improved employability and strong leadership. Successful models are outlined and challenging issues and prospective strategies are presented.

Improving the practicum through collaborative action

Using international concepts of best practice, the research showed that Thai student teacher's practicum is enhanced if there are systematic and sustained opportunities to participate in reflective discussion with peers and lecturers. The research used the Buddhist concept of Kalayanamitr as a metaphor for the relationship between professional practice and reflection on that practice. This research sets new directions for teacher education and educational research in Thailand.

Cross talk : collaborative indigenous life writing in Australia and Canada

This thesis argues that the critical reading of Indigenous life writing needs to move beyond its concern for power relations operating between the narrators and editors of collaboratively produced texts. It discusses the role of Indigenous families and communities in both the production and the reading of Indigenous texts.

Contracting-agency analysis of the association between firm risk, investment opportunity set, corporate governance and firm performance

Tests the efficiency of corporate controls (board monitoring and incentive contracts) for growth or risk firms. By exploring the implications of controls and studying their interactive effects on firm performance, this study demonstrates how and why different firms use corporate governance controls to align managers' and shareholders' interests.

Information provenance for open distributed collaborative system

In autonomously managed distributed systems for collaboration, provenance can facilitate reuse of information that are interchanged, repetition of successful experiments, or to provide evidence for trust mechanisms that certain information existed at a certain period during collaboration. In this paper, we propose domain independent information provenance architecture for open collaborative distributed systems. The proposed system uses XML for interchanging information and RDF to track information provenance. The use of XML and RDF also ensures that information is universally acceptable even among heterogeneous nodes. Our proposed information provenance model can work on any operating systems or workflows.

Enhancing the dietary management of general practice patients through collaborative care: perspectives of general practitioners and dietitians

Aim:  To describe how general practitioners and dietitians view their role in the dietary management of cardiac patients and to provide insights on how to facilitate collaborative care.
Methods:  Two studies were conducted in Victoria (Australia) 2005–2006. Study One: semi-structured interviews with general practitioners. Study Two: cross-sectional quantitative surveys of general practitioners and dietitians. Study One: texts were analysed using the grounded theory approach. Study Two: frequency analysis was conducted and chi-squared test for independence was used to explore the impact of age, sex and consultation time on the role and reporting scales.
Results:  Study One: Themes arising from the interviews with 30 general practitioners showed their involvement in dietary management fell into three broad roles: ‘Influencing’, ‘Coordinator’ of referrals and dietary ‘Educator’. They described dietetic education as a process that included dietary assessment, education, application of behavioural change techniques and reporting back to general practitioners. Study Two: Respondents were 248 general practitioners (30% response) and 180 dietitians (60% response). General practitioners' counselling consisted mostly of advocating for dietary change, coordinating dietetic referrals and reinforcing dietitians' recommendations. General practitioners considered dietary education as the role of dietitians. Dietitians reported a much broader role in the management of patients with some overlap with general practitioners' roles.
Conclusions:   The findings indicate the need: (i) for more structured reporting to ensure general practitioners receive appropriate information to enable them to reinforce dietetic counselling and recommendations; and (ii) to streamline the communication process in order to expedite dietitians' reports to general practitioners.