Thomas Say, early American naturalist,

Mode of access: Internet.

The poetical works of Thomas Chatterton, with notices of his life, history of the Rowley controversy, a selection of his letters, and notes critical and explanatory.

Edited by C. B. Willcox.

Practical moral and political economy : or, The government, religion, and institutions, most conducive to individual happiness and to national power / by T.R. Edmonds, A.B. Trinity College, Cambridge.

Numerous leaves unopened in this copy.

Itinéraire de Constantinople à la Mecque : extrait de l'ouvrage turc intitulé Kitab menassik el-hadj Kitāb manāsik al-ḥajj : livre des prières et des cérémonies relatives au pélerinage imprimé en 1232 (1816-17) /

With notes by Barbié du Bocage and Jomard.

Political pamphlets (United States) from the Durrett collection...1801-[1878] arranged chronologically.

Title page typewritten.

Journal of Daniel Coker, : a descendant of Africa, from the time of leaving New York, in the ship Elizabeth, Capt. Sebor, on a voyage for Sherbro, in Africa, in company with three agents, and about ninety persons of colour. : The Rev. Samuel Bacon, John B. Bankson, Samuel S. Crozer. Agents. : With an appendix.

"Appendix to the Rev. D. Coker's Journal" (pages [41]-52) includes "Letter from Nathaniel Peck to his mother in Baltimore".

The experience of Thomas H. Jones, who was a slave for forty-three years. /

Consult: Dumond, D.L. Antislavery in America, page 70; Library Company of Philadelphia. Afro-Americana, 1553-1906, entry 5395.

B cell chronic lymphocytic leukaemia cells have reduced capacity to upregulate expression of MHC class I in response to interferon-gamma

Aims: An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cells in vivo. To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I expression. Methods: Flow cytometry, TAP allele PCR and MHC class I PCR were used. Results: While baseline expression of MHC class I did not differ, upregulation of MHC class I expression by B-CLL cells in response to IFN-gamma was reduced. No deletions or mutations of TAP 1 or 2 genes were detected. B-CLL cells upregulated TAP protein expression in response to IFN-gamma. Responsiveness of B-CLL MHC class I mRNA to IFN-gamma was not impaired. Conclusions: The data suggest that MHC class I molecules might be less stable at the cell surface in B-CLL than normal B cells, as a result of the described release of beta(2)m and beta(2)m-free class I heavy chains from the membrane. This relative MHC class I expression defect of B-CLL cells may reduce their susceptibility to CTL lysis in response to immunotherapeutic approaches.

T cells signaled by NF-kappa B- dendritic cells are sensitized not anergic to subsequent activation

Paradoxically, while peripheral self-tolerance exists for constitutively presented somatic self Ag, self-peptide recognized in the context of MHC class II has been shown to sensitize T cells for subsequent activation. We have shown that MHC class II(+)CD86(+)CD40(-) DC, which can be generated from bone marrow in the presence of an NF-kappaB inhibitor, and which constitutively populate peripheral tissues and lymphoid organs in naive animals, can induce Ag-specific tolerance. In this study, we show that CD40(-) human monocyte-derived dendritic cells (DC), generated in the presence of an NF-kappaB inhibitor, signal phosphorylation of TCRzeta, but little proliferation or IFN-gamma in vitro. Proliferation is arrested in the G(1)/G(0) phase of the cell cycle. Surprisingly, responding T cells are neither anergic nor regulatory, but are sensitized for subsequent IFN-gamma production. The data indicate that signaling through NF-kappaB determines the capacity of DC to stimulate T cell proliferation. Functionally, NF-kappaB(-)CD40(-)class II+ DC may either tolerize or sensitize T cells. Thus, while CD40(-) DC appear to prime or prepare T cells, the data imply that signals derived from other cells drive the generation either of Ag-specific regulatory or effector cells in vivo.