920 resultados para Andrew Haskell library


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This report was requested by the Innovation and Marketing department of the ETHBibliotek, for the purpose of assessing the social cataloguing tool LibraryThing and its potential uses in an academic library.

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Larnellarins are a group of marine natural products isolated from the prosobranch mollusc Lamellaria sp., the ascidian Didemnum sp., and the sponge Dendrilla Cactos. Several of them exhibit interesting biological activities. Natural as well as synthetic lamellarins should be excellent candidates for the development of new drugs due to their unique skeletal structure and their important biological activities especially as antitumor agents. Lamelarin O has been recently characterized as a topoisomerase 1-targeted anti tumor agent. A variety of synthetic approaches have been developed for this family of alkaloids. Herein we describe a new route to the synthesis of Lamellarin D, from a methyl 2-pyrrolecarboxylate. Transformation of the starting material into the scaffold, a substituted 5,6-dihydropyrrolo (2,l ­a)isoquinoline (5,6-DHPl), was afforded by N-alkylation followed by intramolecular Heck cyclization. From this scaffold the synthetic strategy is based on two sequential regioselective bromination!Suzuki cross-coupling reactions which permitted the introduction of differently substituted aryl groups on positions 1 and 2 followed by oxidation, deprotection, and lactonization.

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El pasado 23 de junio se celebró en Londres una jornada dedicada a los resultados del proyecto LIFE (Life Cycle Information for E-Literature) , centrado en los costes de la preservación digital. Este proyecto, financiado por JISC y llevado a cabo conjuntamente por la British Library (BL) y la University College London (UCL) se ha realizado en 2 fases: en la primera (2005-2006), se elaboró una metodología basada en ciclos vitales (life cycles) para calcular el coste de la preservación de recursos digitales durante 5, 10 y 100 años. Para ello, se identificaron seis procedimientos (o «etapas») considerados básicos para la gestión de material digital y luego se asignaron a cada uno los principales factores de coste. El modelo resultante se aplicó a varias colecciones de la BL y la UCL. ...

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Kristiina Hormia-Poutasen esitys Jerusalemissa Israelin kansalliskirjastossa 8.9.2011

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Kristiina Hormia-Poutasen esitys Danish Research Association -tapahtumassa Tanskassa 15.9.2011

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Kristiina Hormia-Poutasen esitys Jerusalemissa 8.9.2011

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Anders Söderbäckin esitys Kirjastoverkkopäivillä 26.10.2011 Helsingissä.

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Bo Öhrströmin esitys Kirjastoverkkopäivillä 27.10.2011 Helsingissä.

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Johan Rademakersin esitys Kirjastoverkkopäivillä 26.10.2011.

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Esitys Bulgarian kirjastoseuran seminaarissa 15.3.2012

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Markku Laitinen's keynote presentation in the QQML conference in Limerick, Ireland the 23rd of April, 2012.