Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected children.

AIM: To evaluate the long-term safety and effectiveness of lopinavir/ritonavir (LPV/r) in a population-based cohort of HIV-1-infected children. METHODS: All children enrolled in the Swiss Mother and Child HIV Cohort Study, treated with LPV/r-based combination antiretroviral treatment (cART) between November 2000 and October 2008, were included. RESULTS: 88 children (25 (28%) protease inhibitor (PI)-naive, 16 (18%) ART-naive) were analysed (251 patient-years on LPV/r). After 48 weeks on LPV/r, 70 children had a median (interquartile range (IQR)) decrease in HIV-1 viral load of 4.25 log (5.45-3.17; PI-naive, n=17) and 2.53 (3.68-1.38; PI-experienced, n=53). Median (IQR) increase in CD4 count was 429 (203-593; PI-naive) and 177 (21-331; PI-experienced) cells/microl. These effects remained stable throughout 192 weeks for 25 children. Treatment was stopped for viral rebound in seven and suspected toxicity in 12 children. CONCLUSION: Long-term treatment with LPV/r-based cART is safe and effective in HIV-1-infected children.

[Archives de la Parole]. , El Gouali ; Ya Zellai / Maâllem Ali El Kdioui, ghaïtas [acc. perc.]

[Traditions. Afrique du Nord. Maroc]

[Archives de la Parole]. , Baïtan Hemdan ; Moual Resd Eddil / Mohamed Ben Hadj, chant [acc. instr.]

[Traditions. Afrique du Nord. Maroc]

Rates of cultural change and patterns of cultural accumulation in stochastic models of social transmission.

Cultural variation in a population is affected by the rate of occurrence of cultural innovations, whether such innovations are preferred or eschewed, how they are transmitted between individuals in the population, and the size of the population. An innovation, such as a modification in an attribute of a handaxe, may be lost or may become a property of all handaxes, which we call "fixation of the innovation." Alternatively, several innovations may attain appreciable frequencies, in which case properties of the frequency distribution-for example, of handaxe measurements-is important. Here we apply the Moran model from the stochastic theory of population genetics to study the evolution of cultural innovations. We obtain the probability that an initially rare innovation becomes fixed, and the expected time this takes. When variation in cultural traits is due to recurrent innovation, copy error, and sampling from generation to generation, we describe properties of this variation, such as the level of heterogeneity expected in the population. For all of these, we determine the effect of the mode of social transmission: conformist, where there is a tendency for each naïve newborn to copy the most popular variant; pro-novelty bias, where the newborn prefers a specific variant if it exists among those it samples; one-to-many transmission, where the variant one individual carries is copied by all newborns while that individual remains alive. We compare our findings with those predicted by prevailing theories for rates of cultural change and the distribution of cultural variation.

FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.

Fas is a cell surface death receptor that signals apoptosis. Several proteins have been identified that bind to the cytoplasmic death domain of Fas. Fas-associated death domain (FADD), which couples Fas to procaspase-8, and Daxx, which couples Fas to the Jun NH(2)-terminal kinase pathway, bind independently to the Fas death domain. We have identified a 130-kD kinase designated Fas-interacting serine/threonine kinase/homeodomain-interacting protein kinase (FIST/HIPK3) as a novel Fas-interacting protein. Binding to Fas is mediated by a conserved sequence in the COOH terminus of the protein. FIST/HIPK3 is widely expressed in mammalian tissues and is localized both in the nucleus and in the cytoplasm. In transfected cell lines, FIST/HIPK3 causes FADD phosphorylation, thereby promoting FIST/HIPK3-FADD-Fas interaction. Although Fas ligand-induced activation of Jun NH(2)-terminal kinase is impaired by overexpressed active FIST/HIPK3, cell death is not affected. These results suggest that Fas-associated FIST/HIPK3 modulates one of the two major signaling pathways of Fas.

Sweetheart dance ; Lezginka : danse nationale / exécuté par l'orchestre de balalaïkas Kirilloff

[Traditions. Europe. Russie]

Aaqline-gel-Djzalere : chants kabyles ; Anel-áafouar-a-Sidi : chants kabyles / Amar Chaqual, chant ; avec Au Babas

[Traditions. Afrique du Nord. Algérie. Kabylie]

Naächequ lebnats : [Naʿšaq al-bn̄at] ; Marcha Djezireïa : [Marša Gazā iriyya] / Marie Soussan, chant [acc. orch.]. ; Edmond N. Yafil, dir.

[Traditions. Afrique du Nord. Algérie]

Adjouadi hadi : chant du Sud Oranais / par Chikh Hammada, chant [acc. instr.]

[Traditions. Afrique du Nord. Algérie]

Bba-sidi-bba-aouaâdi : chants berbères ; Iliouas-sbah-el-khire : chants kabyles / Amar Chaqual, avec Aubabas, chant

[Traditions. Afrique. Algérie]

Cuantos tormentos me dan : malaguenas del Cojo ; Todos te llaman la diosa / fandango ; por El Cojo de Málaga, chant ; con acompañamiento de guitarra por M. Borrull

[Traditions. Europe. Espagne. Andalousie]

L'Aaroussa : en chleuh ; Moual el bafdani ; L'Aaroussa : en chleuh / troupe Bni Mtir ou Zaïane ; acc. choeurs et tahrija

[Traditions. Afrique du Nord. Maroc]

Le osservationi della lingua volgare di diversi huomini illustri : cioe del Bembo, del Gabrielo, del Fortunio, del Corso, dell' Acarisio, et di altri scrittori... ([Reprod.]) / [Francesco Sansovino]

Collection : Italian books before 1601 ; 192.6

Grains de matière et de lumière. 3, Noyaux des atomes / par Jean Perrin

Collection : Actualités scientifiques et industrielles ; n° 192, V