Photoelectrocatalytic/photoelectro-Fenton coupling system using a nanostructured photoanode for the oxidation of a textile dye: kinetics study and oxidation pathway

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

The oxidation of p-phenylenediamine, an ingredient used for permanent hair dyeing purposes, leads to the formation of hydroxyl radicals: oxidative stress and DNA damage in human immortalized keratinocytes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cadmium stress antioxidant responses and root-to-shoot communication in grafted tomato plants

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Hydrogen peroxide centrally attenuates hyperosmolarity-induced thirst and natriuresis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Formas orgânicas e inorgânicas de fósforo no solo em função de plantas de cobertura e de adubação nitrogenada

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Effects of probiotic Lactobacillus gasseri strains of breast-fed infant in a murine model

The ingestion of probiotic lactic acid bacteria has been evaluated and noted that it has an effect on the balance of desirable microbiota in the gastrointestinal tract. Lactobacillus gasseri demonstrates good survival in the gastrointestinal tract, and it has been associated with a variety of probiotic activities and roles, including the reduction of fecal mutagenic enzymes, the production of bacteriocins and the stimulation of macrophages immunomodulation. The aim of the study was to evaluate the effects of a pool of L. gasseri strains isolated from the feces of breastfed infants added in the human milk of healthy women. The milk was both pasteurized and unpasteurized, to verify the cell cytotoxicity of macrophages and to quantify the production of immunologic mediators such as IL-4, IL-6, IFN-g, TNF-a, NO and oxygen intermediary compounds (H2O2). The administration of raw human milk and pasteurized human milk to infants is a regular, encouraged practice in units of intensive therapy (UITs) and our present investigation verified the beneficial effect of addition of a pool of L. gasseri to pasteurized human milk (PHML). Our results show that probiotic supplementation helped to maintain cell viability, reduced IL-6 and IFN-γ production and stimulated TNF-α, NO, H2O2, IL-4 production. Nevertheless, the results indicate that the addition of lactobacillus to human milk was not a determinant in the production of TNF-α. L. gasseri added to breast milk did not present a cytotoxic risk, and the addition of L. gasseri to pasteurized milk of human milk bank would benefit newborns that depend on milk banks for the colonization of more desirable microbiota.

Stability study of fluconazole applying validated bioassay and stability-indicating LC methods

Chemical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, understanding the factors that change the stability of pharmaceuticals and identifying ways to guarantee their stability are important. In this work stability-indicating Liquid Chromatographic (LC) and bioassay methods were validated and employed in the fluconazole stability studies. The correlation of sample results from both methods was evaluated. Fluconazole raw material stability was investigated in aqueous, acid (0.1 M HCl), alkaline (0.1 M NaOH) and oxidative (3% v/v H2O2) reflux for 6 hours, by LC method. Fluconazole capsules were exposed to UVC (254 nm, 66 and 180 days), climatic chamber (40°C, 75% RH, 90 days) and oven (60°C, 60 days), these samples were analyzed by LC and bioassay methods It was found that the drug is degraded (10% decrease) with arising of a possible degradation product in an oxidative medium and UVC exposure, in all the others conditions fluconazole remained chemically stable (higher than 98%) when analyzed by LC. However when the capsules stressed samples were evaluated through bioassay very low antifungal activity was found (about 30%). Fluconazole showed to be an unstable drug and it indicates that special care must be taken during the handling, storage and quality control using appropriated methods to analyze this therapeutic agent. This work suggests monitoring the fluconazole stability by bioassay and the stability-indicating LC methods.

Oxidation of amino acids by chlorpromazine cation radical and co-catalysis by chlorpromazine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise histológica e imunoistoquímica do tecido pulpar de ratos Wistar submetidos a procedimento clareador com duas concentrações de peróxido de hidrogênio

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência da clareação dentária sobre o tecido pulpar de ratos diabéticos: aspectos histológicos e imunológicos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Acúmulo de cádmio, crômio e níquel e isolamento de micro-organismos potenciais para biorremediação em área agrícola

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização funcional de um fator de transcrição hipotético no fungo Neurospora crassa

Pós-graduação em Biotecnologia - IQ

Eficiência de um sistema de desinfecção solar de águas residuárias domésticas com adição de diferentes doses de peróxido de hidrogênio

Pós-graduação em Agronomia (Irrigação e Drenagem) - FCA

Aperfeiçoamento e avaliação de um novo sistema de digestão assistida por aquecimento condutivo em frasco fechado para preparar amostras de carne “in natura” para análise elementar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Abordagem alternativa para síntese de melanina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)